Gene Report

Basic Information

Approved Symbol	BIN1
Approved Name	bridging integrator 1
Previous Symbol	AMPHL
Symbol Alias	SH3P9, AMPH2
Name Alias	amphiphysin II
Location	2q14
Position	chr2:127805599-127864903 (-)
External Links	Entrez Gene: 274 Ensembl: ENSG00000136717 UCSC: uc002tns.2 HGNC ID: 1052
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between BIN1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
BIN1	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between BIN1 and other components at different levels (count: 0)

Positive relationship network of BIN1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between BIN1 and MDD (count: 0)

Negative relationships between BIN1 and other components at different levels (count: 0)

BIN1 related SNPs in MK4MDD (count: 0)

BIN1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Myc box-dependent-interacting protein 1	O00499	0(0/0)	Gene mapped

BIN1 related GO terms (count: 19)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0008021	synaptic vesicle	cellular component	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0019048	virus-host interaction	biological process	IEA
GO:0045807	positive regulation of endocytosis	biological process	IEA
GO:0043196	varicosity	cellular component	IEA
GO:0043547	positive regulation of GTPase activity	biological process	IEA
GO:0032403	protein complex binding	molecular function	IEA
GO:0015629	actin cytoskeleton	cellular component	TAS[9182667]
GO:0044300	cerebellar mossy fiber	cellular component	IEA
GO:0042692	muscle cell differentiation	biological process	IEA
GO:0005515	protein binding	molecular function	IPI[16275660]
GO:0008283	cell proliferation	biological process	TAS[8782822]
GO:0007275	multicellular organismal development	biological process	IEA
GO:0006897	endocytosis	biological process	IEA
GO:0046982	protein heterodimerization activity	molecular function	IEA
GO:0043679	axon terminus	cellular component	IEA
GO:0019904	protein domain specific binding	molecular function	IEA
GO:0005737	cytoplasm	cellular component	IDA
GO:0005634	nucleus	cellular component	IEA
GO:0051020	GTPase binding	molecular function	IEA

BIN1 related KEGG pathways (count: 0)

BIN1 related BioCarta pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped BioCarta pathways
NDKDYNAMIN_PATHWAY	ndkdynamin pathway	Endocytotic role of NDK, Phosphins and Dynamin	Reliable neurotransmitter release requires the presence of s...... Reliable neurotransmitter release requires the presence of sufficent numbers of synaptic vesicles. The process of synaptic vesicle endocytosis (SVE) is coordinated by a group of proteins called dephosphins. The current set of seven known dephosphins are nerve treminal proteins with little or no structural hoimology but satisfy two essential criteria: they are essential for SVE and they are rapidly and coordinately dephosphorlyated in response to a calcium influx through voltage-dependent calicium channels. The calicium signal is mediated by calmodulin (CaM) and calcineurin. Each dephosphin plays an essential role in overlapping phases or segments of the cycle. The four phases of SVE are nucleation, invagination, fission and uncoating. In this diagram the internalization of the vesicle is the uncoating step. In order to illustrate the complexity of this process the initial display of the protein is labelled with a name and a number. This number is then used at the decloaking or uncoating step to show the release and seperation of the various factors. Each step in the process has a different set of complex components. The components are shown in highlighted boxes above. The nucleation phase initiates with the activation of CaM/Calcineurin and the subsequent dephosphorylation of AP180. AP180 and clathrin are then recruited to the membrane by AP2 and PtdIns(4,5)P2 (comma shaped molecule in the diagram). Nucleation is completed by the addition of epsin and eps15. Invagination proceeds with the formation of the amphiphysin1/2 heterodimer and its addition to the maturing vesicle surface complexes. The final components, dynamin and synaptojanin, are recruited to the budding vesicle by the amphiphysin1/2 heterodimer. Dynamin forms a complete ring around the vesicle neck and completes fission via its PtdIns(4,5)P2 stimulated GTPase activity. After internalization the vesicle is quickly uncoated, in a process believed to be mediated by synaptojanin, and is accompnied by the disassembly of clathrin. More...

BIN1 related Reactome pathways (count: 0)

BIN1 related interactors from protein-protein interaction data in HPRD (count: 30)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
BIN1	DLGAP4	No	in vitro;in vivo;yeast 2-hybrid	16275660
BIN1	PLD2	No	in vitro	10764771
BIN1	XRCC4	No	in vitro;in vivo;yeast 2-hybrid	16275660
BIN1	ITGA3	No	yeast 2-hybrid	10094488
BIN1	FBP1	No	in vitro;in vivo;yeast 2-hybrid	16275660
BIN1	MYC	No	in vitro;in vivo	11306501
BIN1	ASAP2	No	in vitro	15483625
BIN1	SOS1	No	in vitro	9182529
BIN1	CUX1	No	yeast 2-hybrid	16169070
BIN1	RAP1A	No	in vivo	15207703
BIN1	DNM2	No	in vitro	15483625
BIN1	ATXN2	No	in vivo;yeast 2-hybrid	16115810
BIN1	MAP4K3	No	in vitro	11384986
BIN1	SH3GL2	No	in vitro	9315708
BIN1	DNM1	No	in vitro;in vivo	9280305 , 9195986 , 16275660
BIN1	ITGA1	No	yeast 2-hybrid	10094488
BIN1	AP2A2	No	in vitro	10430869
BIN1	SYN1	Yes	in vitro;in vivo	10899172
BIN1	ABL1	No	in vitro;in vivo	9356459
BIN1	AP2A1	No	in vitro	9280305
BIN1	RIN3	No	in vitro;yeast 2-hybrid	12972505
BIN1	SYNJ1	No	in vitro	9341169 , 9195986
BIN1	BIN1	Yes	in vitro	10391921
BIN1	TP73	No	in vitro;in vivo;yeast 2-hybrid	11709703
BIN1	SH3GLB1	No	in vitro	12456676
BIN1	RIN2	No	in vitro	12972505
BIN1	AMPH	Yes	in vitro;in vivo	9348539
BIN1	SNX4	No	in vivo;yeast 2-hybrid	12668730
BIN1	PTK2	No	in vitro	12558988
BIN1	ITGA6	No	yeast 2-hybrid	10094488

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped BioCarta pathways