MK4MDD

Gene Report

Basic Information
Approved Symbol MAOA
Approved Name monoamine oxidase A
Location Xp11.4-p11.3
Position chrX:43603761-43606071 (+)
External Links Entrez Gene: 4128
Ensembl: ENSG00000189221
UCSC: uc004dfy.4
HGNC ID: 6833
No. of Studies (Positive/Negative) 13(9/4) Help
Type Literature-origin; SNP mapped; Protein mapped

Positive relationships between MAOA and MDD (count: 7)
Name in Literature Reference Research Type Statistical Result Relation Description Help
MAO-A Schulze, 2000 patients and normal controls We observed a significantly increased frequency of genotypes...... We observed a significantly increased frequency of genotypes containing only long alleles in female patients with recurrent major depression in comparison with age- and sex-matched controls. More...
MAO-A Du, 2004 patients and normal controls The EcoRV polymorphism was found to be associated with depre...... The EcoRV polymorphism was found to be associated with depression in males but not in females. Haplotype analysis revealed that one of the haplotypes (EcoRV2-uVNTR1) was significantly more frequent among male patients than male controls. More...
MAOA Yu, 2005 patients and normal controls P-value=0.024 Our results showed a significantly increased frequency of 4-...... Our results showed a significantly increased frequency of 4-repeat (4R) allele in MDD patients, especially in the female population. Furthermore, MDD female patients who were 3R homozygotes had a significantly better response to 4-week fluoxetine treatment when compared to 4R carriers (p=0.024), More...
MAOA Rivera M, 2009 nomal people OR = 1.91; 95% CI=(1.26-2.91); P = 0.0014 We found associations between all three depressive phenotype...... We found associations between all three depressive phenotypes and either high-activity alleles or high-activity genotypes in both sexes. The associations were statistically significant for females but not for males. Testing the same associations on the entire sample (males and females) also yielded significant associations between depression and either high-activity alleles or high-activity genotype distribution that were independent of age and/or gender (ICD-10 DE: OR = 1.98; 95% CI: 1.42-1.77; P = 0.00002; ICD-10-SDE: OR = 2.05; 95% CI: 1.38-3.05; P = 0.0002; DSM-IV MD: OR = 1.91; 95% CI: (1.26-2.91); P = 0.0014). More...
MAOA Huang, 2009 patients and normal controls P-value<0.05 Among the females, an association was found between MAOA pol...... Among the females, an association was found between MAOA polymorphisms and severe MDD (P=0.041 for uVNTR and 0.017 for EcoRV (rs1137070), respectively). More...
MAOA Zhang, 2009 patients and normal controls P-value=0.002 Compared with the normal controls, MAOA VNTR genotype was si...... Compared with the normal controls, MAOA VNTR genotype was significantly more frequent in female major depression patients (P=0.002), but not in male patients (P=0.17). More...
MAOA Lung, 2011 patients and normal controls chi2 = 4.182, P-value= 0.041 The MAOA 4R allele was more frequent in males with MDD than ...... The MAOA 4R allele was more frequent in males with MDD than in male community controls (chi2 = 4.182, p= 0.041). More...

Positive relationships between MAOA and other components at different levels (count: 3) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of MAOA in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between MAOA and MDD (count: 4)
Name in Literature Reference Research Type Statistical Result Relation Description
MAOA Syagailo YV, 2001 Patients and nomal controls Statistical analysis showed no significant differences in al...... Statistical analysis showed no significant differences in allele or genotype frequencies between control and patient groups. More...
MAOA Tadic A, 2003 Patients and nomal controls No association was observed in MD No association was observed in MD
MAOA Gutierrez B, 2004 No association was found between the uMAOA locus and bipolar...... No association was found between the uMAOA locus and bipolar disorder or major depression. More...
MAOA Liu, 2015 Patients and nomal controls p>0.1 The meta-analysis showed no significant associations with MD...... The meta-analysis showed no significant associations with MDD for the overall alleles or for A2, A5, or A6 in any of the groups (all p>0.1). More...

Negative relationships between MAOA and other components at different levels (count: 0) Help
MAOA related SNPs in MK4MDD (count: 2)
MAOA related proteins in MK4MDD (count: 2)
MAOA related GO terms (count: 17)
MAOA related KEGG pathways (count: 7)
MAOA related BioCarta pathways (count: 0)
MAOA related Reactome pathways (count: 6)
MAOA related interactors from protein-protein interaction data in HPRD (count: 2)