Gene Report

Basic Information

Approved Symbol	DBH
Approved Name	dopamine beta-hydroxylase (dopamine beta-monooxygenase)
Symbol Alias	DBM
Location	9q34
Position	chr9:136501485-136524466 (+)
External Links	Entrez Gene: 1621 Ensembl: ENSG00000123454 UCSC: uc004cel.3 HGNC ID: 2689
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin; Protein mapped

Positive relationships between DBH and MDD (count: 0)

Positive relationships between DBH and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
DbetaH gene (DBH)		Psychotic symptoms(paranoid ideation)	symptoms	Wood, 2002	patients and normal controls		Patients who possessed the A allele were significantly more ...... Patients who possessed the A allele were significantly more likely to have higher scores for interpersonal sensitivity and paranoia than patients without the A allele (p =.004 and p =.048, respectively), suggesting that this allele may predispose patients to paranoia in major depression. More...

Positive relationship network of DBH in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between DBH and MDD (count: 0)

Negative relationships between DBH and other components at different levels (count: 0)

DBH related SNPs in MK4MDD (count: 0)

DBH related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Dopamine beta-hydroxylase	P09172	1(1/0)	Literature-origin

DBH related GO terms (count: 36)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0007268	synaptic transmission	biological process	TAS[2880016]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0030141	secretory granule	cellular component	TAS
GO:0048265	response to pain	biological process	IEA
GO:0003824	catalytic activity	molecular function	TAS[3443096]
GO:0042420	dopamine catabolic process	biological process	IEA
GO:0005576	extracellular region	cellular component	NAS[14718574]
GO:0042981	regulation of apoptotic process	biological process	IEA
GO:0007613	memory	biological process	IEA
GO:0002443	leukocyte mediated immunity	biological process	IEA
GO:0042583	chromaffin granule	cellular component	NAS
GO:0034466	chromaffin granule lumen	cellular component	IEA
GO:0001975	response to amphetamine	biological process	IEA
GO:0042421	norepinephrine biosynthetic process	biological process	IEA
GO:0044281	small molecule metabolic process	biological process	TAS
GO:0001816	cytokine production	biological process	IEA
GO:0008542	visual learning	biological process	IEA
GO:0004500	dopamine beta-monooxygenase activity	molecular function	TAS
GO:0005507	copper ion binding	molecular function	IEA
GO:0031418	L-ascorbic acid binding	molecular function	IEA
GO:0016021	integral to membrane	cellular component	IEA
GO:0042593	glucose homeostasis	biological process	IEA
GO:0016020	membrane	cellular component	TAS[3443096]
GO:0042423	catecholamine biosynthetic process	biological process	TAS
GO:0050900	leukocyte migration	biological process	IEA
GO:0001974	blood vessel remodeling	biological process	IEA
GO:0005737	cytoplasm	cellular component	TAS[3443096]
GO:0042596	fear response	biological process	IEA
GO:0042711	maternal behavior	biological process	IEA
GO:0030658	transport vesicle membrane	cellular component	IEA
GO:0007626	locomotory behavior	biological process	IEA
GO:0042309	homoiothermy	biological process	IEA
GO:0042127	regulation of cell proliferation	biological process	IEA
GO:0045907	positive regulation of vasoconstriction	biological process	IEA
GO:0042584	chromaffin granule membrane	cellular component	IEA
GO:0034641	cellular nitrogen compound metabolic process	biological process	TAS
GO:0048149	behavioral response to ethanol	biological process	IEA

DBH related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa00350	tyrosine metabolism	Tyrosine metabolism

DBH related BioCarta pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped BioCarta pathways
NEUROTRANSMITTERS_PATHWAY	neurotransmitters pathway	Biosynthesis of neurotransmitters	Neurotransmitters are signaling molecules used by neurons to...... Neurotransmitters are signaling molecules used by neurons to communicate across chemical synapses. The receptors for neurotransmitters include G-protein coupled receptors (GPCRs) and ligand-gated ion channels. The biogenic amines are neurotransmitters derived from amino acids, and include dopamine, epinephrine, GABA, histamine and serotonin. For each of these, decarboxylation of an amino acid is a key step. GABA, gamma-aminobutyric acid, is a key inhibitory neurotransmitter and is synthesized through the decarboxylation of glutamate in a single step. Glutamate is itself an abundant excitatory neurotransmitter. Histamine signals are involved in inflammation and acid secretion in the stomach, acting through GPCRs. Histamine is synthesized in a single step from the amino acid histidine through decarboxylation. Serotonin is a neurotransmitter with a large range of effects, including roles in mood and depression, and is synthesized by first adding a hydroxyl group to tryptophan, followed by decarboxylation. A common mechanism of antidepressant action is to block the reuptake of serotonin at synapses. Dopamine is involved in movement and mood and is derived from tyrosine through addition of a hydroxyl group and decarboxylation. Additional reactions create norepinephrine and epinephrine from dopamine. These molecules, also called adrenalin and noradrenalin, act on the adrenergic receptors to exert responses including alteration of blood pressure, heart rate, metabolic activity, and bronchodilation. Many common drugs such as asthma and heart pressure medications act on adrenergic receptors. Alterations in these biosynthetic pathways can lead to significant clinical consequences. For example, deficiency in tyrosine hydroxylase activity leads to a movement disorder similar to Parkinson's disease and may play a role in Parkinson's disease and the development of an autoimmune response against glutamate decarboxylase (GAD) may trigger the destruction of insulin-secreting cells and type I diabetes. Numerous studies have searched for a potential genetic role of tryptophan hydroxylase mutations in neuropsychiatric indications, with conflicting results. More...

DBH related Reactome pathways (count: 5)

ID	Name	Description
Gene mapped Reactome pathways
REACT_15314	hormone biosynthesis	Hormones are chemicals released in very small quantities by ...... Hormones are chemicals released in very small quantities by cells that affect cellular metabolism in other parts of the body. They can also act as chemical messengers that transport signals from one cell to another. All multicellular organisms produce hormones; these are often transported in the blood. Cells respond to a hormone when they express a specific receptor for that hormone. The hormone binds to the receptor, resulting in the activation of a signal transduction mechanism that ultimately leads to cell type-specific responses. The events annotated here describe the biosynthesis of many types of hormones. More...
REACT_13477	transmission across_chemical_synapses	Chemical synapses are specialized junctions that are used fo...... Chemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron, muscle cell or glad cell. The pre and the post-synaptic cell are separated by a gap of 20nm called the synaptic cleft. The signals pass in a unidirection from pre-synaptic to post-synaptic. The pre-synaptic neuron communicates via the release of neurotransmitter which bind the receptors on the post-synaptic cell. More...
REACT_13723	neurotransmitter release_cycle	Neurotransmitter is stored in the synaptic vesicle in the pr...... Neurotransmitter is stored in the synaptic vesicle in the pre-synaptic terminal prior to its release in the synaptic cleft upon depolarization of the pre-synaptic membrane. The release of the neurotransmitter is a multi-step process that is controlled by electrical signals passing through the axons in form of action potential. Neurotransmitters include glutamate, acetylcholine, nor-epinephrine, dopamine and seratonin. Each of the neurotransmitter cycle is independently described. More...
REACT_15513	amine derived_hormones	Catecholamines and thyroxine are synthesized from tyrosine, ...... Catecholamines and thyroxine are synthesized from tyrosine, and serotonin and melatonin from tryptophan. More...
REACT_15418	norepinephrine neurotransmitter_release_cycle	Noradrenalin release cycle consists of reacidification of th...... Noradrenalin release cycle consists of reacidification of the empty clathrin sculpted monoamine transport vesicle, loading of dopamine into reacidified clathrin coated monamine transport vesicle, conversion of dopamine into Noradrenalin, docking and priming of the noradrenalin synaptic veiscle and then release of noradrenalin synaptic vesicle. In the peripheral nervous system in the peripheral nervous system noradrenalin is stored in large and small dense vesicles and is realesed from large vesicles. More...

DBH related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
DBH	C2orf7	No	in vitro	15498570
DBH	DBH	Yes	in vivo	3972830

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped BioCarta pathways

Gene mapped Reactome pathways