MK4MDD

Gene Report

Basic Information
Approved Symbol TPH1
Approved Name tryptophan hydroxylase 1
Previous Symbol TPRH, TPH
Previous Name "tryptophan hydroxylase (tryptophan 5-monooxygenase)"
Name Alias "tryptophan 5-monooxygenase"
Location 11p15.3-p14
Position chr11:18062310-18062335 (-)
External Links Entrez Gene: 7166
Ensembl: ENSG00000129167
UCSC: uc001mnp.2
HGNC ID: 12008
No. of Studies (Positive/Negative) 13(9/4) Help
Type Literature-origin

Positive relationships between TPH1 and MDD (count: 6)
Name in Literature Reference Research Type Statistical Result Relation Description Help
tryptophan hydroxylase gene Tan, 2003 patients and normal controls Significant difference in genotype frequency between patient...... Significant difference in genotype frequency between patient and control groups was observed More...
TPH-1 Gizatullin, 2006 patients and normal controls Single marker association analyses showed only one SNP signi...... Single marker association analyses showed only one SNP significantly associated with MD. Several haplotypes were associated with MD. More...
TPH1 Anttila, 2007 patients and normal controls Subjects carrying TPH1 CC genotype are more likely to belong...... Subjects carrying TPH1 CC genotype are more likely to belong to the patient sample than to the controls More...
tryptophan hydroxylase 1 (TPH1) Viikki, 2010 patients and normal controls TPH1 218A/C polymorphism was associated with the risk of MDD...... TPH1 218A/C polymorphism was associated with the risk of MDD. More...
TPH1 Belzeaux, 2010 patients and normal controls We found that variations of mRNA levels for NRG1, SORT1 and ...... We found that variations of mRNA levels for NRG1, SORT1 and TPH1 were interesting state-dependent biological markers of the disease. More...
TPH1 Wang, 2011 patients and normal controls P-value = 0.025 The TPH1 218A/C allele frequencies differed significantly be...... The TPH1 218A/C allele frequencies differed significantly between healthy controls and MDD patients in Taiwan, with a higher prevalence of the A allele in the patient group (p = 0.025). More...

Positive relationships between TPH1 and other components at different levels (count: 3) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of TPH1 in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between TPH1 and MDD (count: 2)
Name in Literature Reference Research Type Statistical Result Relation Description
TPH Ham BJ, 2005 Patients and nomal controls There were no significant differences in genotypes and allel...... There were no significant differences in genotypes and allele frequencies between the MDD patients (n = 93) and the control group (n = 127) and in the antidepressant response among TPH gene variants. More...
TPH Yoon HK, 2008 Patients and nomal controls There were no significant differences in the genotype distri...... There were no significant differences in the genotype distributions or allelic frequencies in the two serotonergic polymorphisms between suicide attempters and normal controls. None of the two serotonergic polymorphisms was correlated with lethality. More...

Negative relationships between TPH1 and other components at different levels (count: 2) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


TPH1 related SNPs in MK4MDD (count: 0)
TPH1 related proteins in MK4MDD (count: 0)
TPH1 related GO terms (count: 17)
TPH1 related KEGG pathways (count: 1)
TPH1 related BioCarta pathways (count: 1)
TPH1 related Reactome pathways (count: 5)
TPH1 related interactors from protein-protein interaction data in HPRD (count: 3)