Gene Report

Basic Information

Approved Symbol	PDE4A
Approved Name	phosphodiesterase 4A, cAMP-specific
Previous Symbol	DPDE2
Previous Name	phosphodiesterase 4A, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E2)
Name Alias	phosphodiesterase E2 dunce homolog (Drosophila)
Location	19p13.2
Position	chr19:10527449-10580307 (+)
External Links	Entrez Gene: 5141 Ensembl: ENSG00000065989 UCSC: uc002moj.2 HGNC ID: 8780
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between PDE4A and MDD (count: 0)

Positive relationships between PDE4A and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
Pde4a		SLC17A7(vesicular glutamate transporter 1 (VGLUT1))	gene	Tordera RM, 2011	animal model		gene was regulated in frontal cortex of VGLUT1(+/-) mice gene was regulated in frontal cortex of VGLUT1(+/-) mice

Positive relationship network of PDE4A in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between PDE4A and MDD (count: 0)

Negative relationships between PDE4A and other components at different levels (count: 0)

PDE4A related SNPs in MK4MDD (count: 0)

PDE4A related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	P27815	0(0/0)	Gene mapped

PDE4A related GO terms (count: 13)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0046872	metal ion binding	molecular function	IEA
GO:0048471	perinuclear region of cytoplasm	cellular component	IDA[11306681]
GO:0007165	signal transduction	biological process	IEA
GO:0035690	cellular response to drug	biological process	IEA
GO:0016020	membrane	cellular component	TAS[9677330]
GO:0005829	cytosol	cellular component	TAS
GO:0005515	protein binding	molecular function	IPI[11306681]
GO:0007608	sensory perception of smell	biological process	IEA
GO:0006198	cAMP catabolic process	biological process	IEA; IMP[17704206]
GO:0032587	ruffle membrane	cellular component	IEA
GO:0010738	regulation of protein kinase A signaling cascade	biological process	IEA
GO:0043949	regulation of cAMP-mediated signaling	biological process	IEA
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	molecular function	TAS[9677330]

PDE4A related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa00230	purine metabolism	Purine metabolism

PDE4A related BioCarta pathways (count: 0)

PDE4A related Reactome pathways (count: 4)

ID	Name	Description
Gene mapped Reactome pathways
REACT_15334	darpp32 events	Dopamine- and cAMP-regulated phosphoprotein, Mr 32 kDa (DARP...... Dopamine- and cAMP-regulated phosphoprotein, Mr 32 kDa (DARPP-32), was identified as a major target for dopamine and protein kinase A (PKA) in striatum. Recent advances now indicate that regulation DARPP-32 phosphorylation provides a mechanism for integrating information arriving at dopaminoceptive neurons, in multiple brain regions, via a variety of neurotransmitters, neuromodulators, neuropeptides, and steroid hormones. Activation of PKA or PKG stimulates DARPP-32 phosphorylation at Thr34, converting DARPP-32 into a potent inhibitor of protein phosphatase-1 (PP-1). DARPP-32 is also phosphorylated at Thr75 by Cdk5, converting DARPP-32 into an inhibitor of PKA. Thus, DARPP-32 has the unique property of being a dual-function protein, acting either as an inhibitor of PP-1 or of PKA. More...
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...
REACT_15295	opioid signalling	Opioids are chemical substances similar to opiates, the acti...... Opioids are chemical substances similar to opiates, the active substances found in opium (morphine, codeine etc.). Opioid action is mediated by the receptors for endogenous opioids; peptides such as the enkephalins, the endorphins or the dynorphins. Opioids possess powerful analgesic and sedative effects, and are widely used as pain-killers. Their main side-effect is the rapid establishment of a strong addiction. Opioids receptors are G-protein coupled receptors (GPCR). There are four classes of receptors: mu (MOR), kappa (KOR) and delta (DOR), and the nociceptin receptor (NOP). More...
REACT_19327	g alpha_s_signalling_events	The general function of the G alpha (s) subunit (Gs) is to a...... The general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to collectively as Protein Kinase A). The signal from the ligand-stimulated GPCR is amplified because the receptor can activate several Gs heterotrimers before it is inactivated. More...

PDE4A related interactors from protein-protein interaction data in HPRD (count: 3)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
PDE4A	PDE4A	Yes	in vivo	11566027
PDE4A	AIP	No	in vitro;in vivo;yeast 2-hybrid	12810716
PDE4A	LYN	No	in vitro	10206997 , 12810716

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways