Gene Report

Basic Information

Approved Symbol	GRIK5
Approved Name	glutamate receptor, ionotropic, kainate 5
Previous Symbol	GRIK2
Symbol Alias	GluK5, KA2
Location	19q13.2
Position	chr19:42502468-42569957 (-)
External Links	Entrez Gene: 2901 Ensembl: ENSG00000105737 UCSC: uc002osj.1 HGNC ID: 4583
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between GRIK5 and MDD (count: 0)

Positive relationships between GRIK5 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
Grik5		SLC17A7(vesicular glutamate transporter 1 (VGLUT1))	gene	Tordera RM, 2011	animal model		gene was regulated in frontal cortex of VGLUT1(+/-) mice gene was regulated in frontal cortex of VGLUT1(+/-) mice

Positive relationship network of GRIK5 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between GRIK5 and MDD (count: 0)

Negative relationships between GRIK5 and other components at different levels (count: 0)

GRIK5 related SNPs in MK4MDD (count: 0)

GRIK5 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Glutamate receptor ionotropic, kainate 5	Q16478	0(0/0)	Gene mapped

GRIK5 related GO terms (count: 23)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0007268	synaptic transmission	biological process	NAS; TAS
GO:0030054	cell junction	cellular component	IEA
GO:0035249	synaptic transmission, glutamatergic	biological process	IEA
GO:0045211	postsynaptic membrane	cellular component	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0043204	perikaryon	cellular component	IEA
GO:0042802	identical protein binding	molecular function	IEA
GO:0060079	regulation of excitatory postsynaptic membrane potential	biological process	IEA
GO:0042734	presynaptic membrane	cellular component	IEA
GO:0015277	kainate selective glutamate receptor activity	molecular function	IDA[1321949]
GO:0051649	establishment of localization in cell	biological process	IEA
GO:0032983	kainate selective glutamate receptor complex	cellular component	IEA
GO:0005886	plasma membrane	cellular component	TAS
GO:0043113	receptor clustering	biological process	IEA
GO:0016021	integral to membrane	cellular component	NAS
GO:0014069	postsynaptic density	cellular component	IEA
GO:0006621	protein retention in ER lumen	biological process	IEA
GO:0017124	SH3 domain binding	molecular function	IEA
GO:0005234	extracellular-glutamate-gated ion channel activity	molecular function	IEA
GO:0030165	PDZ domain binding	molecular function	IEA
GO:0043195	terminal bouton	cellular component	IEA
GO:0043525	positive regulation of neuron apoptotic process	biological process	IEA
GO:0071333	cellular response to glucose stimulus	biological process	IEA
GO:0031630	regulation of synaptic vesicle fusion to presynaptic membrane	biological process	IEA

GRIK5 related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa04080	neuroactive ligand_receptor_interaction	Neuroactive ligand-receptor interaction

GRIK5 related BioCarta pathways (count: 0)

GRIK5 related Reactome pathways (count: 4)

ID	Name	Description
Gene mapped Reactome pathways
REACT_21322	ionotropic activity_of_kainate_receptors	Kainate receptors are either Ca2+ permeable or impermeable d...... Kainate receptors are either Ca2+ permeable or impermeable depending on the composition of the receptor and the editing status of subunits GluR5 and GluR6 (GRIK1 and 2). More...
REACT_21312	activation of_kainate_receptors_upon_glutamate_binding	Kainate receptors are found both in the presynaptc terminals...... Kainate receptors are found both in the presynaptc terminals and the postsynaptic neurons. Kainate receptor activation could lead to either ionotropic activity (influx of Ca2+ or Na+ and K+) in the postsynaptic neuron or coupling of the receptor with G proteins in the presynaptic and the postsynaptic neurons. Kainate receptors are tetramers made from subunits GRIK1-5 or GluR5-7 and KA1-2. Activation of kainate receptors made from GRIK1 or KA2 release Ca2+ from the intracellular stores in a G protein-dependent manner. The G protein involved in this process is sensitive to pertussis toxin. More...
REACT_15370	neuroransmitter receptor_binding_and_downstream_transmission_in_the_postsynaptic_cell	The neurotransmitter in the synaptic cleft released by the p...... The neurotransmitter in the synaptic cleft released by the pre-synaptic neuron binds specific receptors located on the post-synaptic terminal. These receptors are either ion channels or G protein coupled receptors that function to transmit the signals from the post-synaptic membrane to the cell body. More...
REACT_13477	transmission across_chemical_synapses	Chemical synapses are specialized junctions that are used fo...... Chemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron, muscle cell or glad cell. The pre and the post-synaptic cell are separated by a gap of 20nm called the synaptic cleft. The signals pass in a unidirection from pre-synaptic to post-synaptic. The pre-synaptic neuron communicates via the release of neurotransmitter which bind the receptors on the post-synaptic cell. More...

GRIK5 related interactors from protein-protein interaction data in HPRD (count: 8)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
GRIK5	GRIK3	Yes	in vivo	9466455
GRIK5	LRSAM1	No	yeast 2-hybrid	16169070
GRIK5	GOLM1	No	yeast 2-hybrid	16169070
GRIK5	GRIK2	No	in vivo	9466455
GRIK5	DLG4	Yes	in vitro;in vivo	9808460 , 11279111
GRIK5	GPAA1	No	yeast 2-hybrid	16169070
GRIK5	MLF1	No	yeast 2-hybrid	16169070
GRIK5	GRID2	Yes	in vivo	12573530

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways