MK4MDD

Gene Report

Basic Information
Approved Symbol GRIK3
Approved Name glutamate receptor, ionotropic, kainate 3
Symbol Alias GluK3, GLUR7
Location 1p34.3
Position chr1:37499710-37499844 (-)
External Links Entrez Gene: 2899
Ensembl: ENSG00000163873
UCSC: uc001caz.2
HGNC ID: 4581
No. of Studies (Positive/Negative) 1(1/0) Help
Type Literature-origin

Positive relationships between GRIK3 and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description Help
human kainate receptor GluR7 gene (GRIK3) Schiffer, 2007 patients and normal controls P-value=0.0012 We detected a significant linkage disequilibrium (LD) indica...... We detected a significant linkage disequilibrium (LD) indicated by preferential maternal transmission of the GluR7 S310 allele to R-MDD patients (P = 0.012), but not to bipolar I disorder (BPI) patients (P = 1.00). We performed a second independent study by applying the TDT in 81 parent-offspring triads from families that inherit recurrent early-onset major depressive disorder (RE-MDD). The results from this second study showed only a suggestive maternal association (P = 0.068). More...

Positive relationships between GRIK3 and other components at different levels (count: 0) Help
Positive relationship network of GRIK3 in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between GRIK3 and MDD (count: 0)
Negative relationships between GRIK3 and other components at different levels (count: 0) Help
GRIK3 related SNPs in MK4MDD (count: 0)
GRIK3 related proteins in MK4MDD (count: 0)
GRIK3 related GO terms (count: 22)
GRIK3 related KEGG pathways (count: 1)
GRIK3 related BioCarta pathways (count: 0)
GRIK3 related Reactome pathways (count: 4)
GRIK3 related interactors from protein-protein interaction data in HPRD (count: 2)