Gene Report

Basic Information

Approved Symbol	GRIK3
Approved Name	glutamate receptor, ionotropic, kainate 3
Symbol Alias	GluK3, GLUR7
Location	1p34.3
Position	chr1:37499710-37499844 (-)
External Links	Entrez Gene: 2899 Ensembl: ENSG00000163873 UCSC: uc001caz.2 HGNC ID: 4581
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between GRIK3 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
human kainate receptor GluR7 gene (GRIK3)	Schiffer, 2007	patients and normal controls	P-value=0.0012	We detected a significant linkage disequilibrium (LD) indica...... We detected a significant linkage disequilibrium (LD) indicated by preferential maternal transmission of the GluR7 S310 allele to R-MDD patients (P = 0.012), but not to bipolar I disorder (BPI) patients (P = 1.00). We performed a second independent study by applying the TDT in 81 parent-offspring triads from families that inherit recurrent early-onset major depressive disorder (RE-MDD). The results from this second study showed only a suggestive maternal association (P = 0.068). More...

Positive relationships between GRIK3 and other components at different levels (count: 0)

Positive relationship network of GRIK3 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between GRIK3 and MDD (count: 0)

Negative relationships between GRIK3 and other components at different levels (count: 0)

GRIK3 related SNPs in MK4MDD (count: 0)

GRIK3 related proteins in MK4MDD (count: 0)

GRIK3 related GO terms (count: 22)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0030054	cell junction	cellular component	IEA
GO:0045211	postsynaptic membrane	cellular component	IEA
GO:0007268	synaptic transmission	biological process	TAS

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0030425	dendrite	cellular component	ISS
GO:0004970	ionotropic glutamate receptor activity	molecular function	IDA[11124978]; ISS
GO:0043204	perikaryon	cellular component	ISS
GO:0032839	dendrite cytoplasm	cellular component	ISS
GO:0042391	regulation of membrane potential	biological process	IDA[11124978]; ISS
GO:0043195	terminal bouton	cellular component	ISS
GO:0015277	kainate selective glutamate receptor activity	molecular function	IDA[7719709]
GO:0035235	ionotropic glutamate receptor signaling pathway	biological process	IDA[7719709\|11124978]; IEA; ISS
GO:0005887	integral component of plasma membrane	cellular component	IDA[7719709]
GO:0008066	glutamate receptor activity	molecular function	TAS[8128318]
GO:0007216	G-protein coupled glutamate receptor signaling pathway	biological process	IDA[9144652]
GO:0007215	glutamate receptor signaling pathway	biological process	IDA[7719709]
GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway	biological process	IDA[9144652]
GO:0001640	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity	molecular function	IDA[9144652]
GO:0005234	extracellular-glutamate-gated ion channel activity	molecular function	IEA
GO:0005886	plasma membrane	cellular component	TAS
GO:0051967	negative regulation of synaptic transmission, glutamatergic	biological process	ISS
GO:0034220	ion transmembrane transport	biological process	IEA
GO:0030424	axon	cellular component	ISS

GRIK3 related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa04080	neuroactive ligand_receptor_interaction	Neuroactive ligand-receptor interaction

GRIK3 related BioCarta pathways (count: 0)

GRIK3 related Reactome pathways (count: 4)

ID	Name	Description
Gene mapped Reactome pathways
REACT_21312	activation of_kainate_receptors_upon_glutamate_binding	Kainate receptors are found both in the presynaptc terminals...... Kainate receptors are found both in the presynaptc terminals and the postsynaptic neurons. Kainate receptor activation could lead to either ionotropic activity (influx of Ca2+ or Na+ and K+) in the postsynaptic neuron or coupling of the receptor with G proteins in the presynaptic and the postsynaptic neurons. Kainate receptors are tetramers made from subunits GRIK1-5 or GluR5-7 and KA1-2. Activation of kainate receptors made from GRIK1 or KA2 release Ca2+ from the intracellular stores in a G protein-dependent manner. The G protein involved in this process is sensitive to pertussis toxin. More...
REACT_13477	transmission across_chemical_synapses	Chemical synapses are specialized junctions that are used fo...... Chemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron, muscle cell or glad cell. The pre and the post-synaptic cell are separated by a gap of 20nm called the synaptic cleft. The signals pass in a unidirection from pre-synaptic to post-synaptic. The pre-synaptic neuron communicates via the release of neurotransmitter which bind the receptors on the post-synaptic cell. More...
REACT_15370	neuroransmitter receptor_binding_and_downstream_transmission_in_the_postsynaptic_cell	The neurotransmitter in the synaptic cleft released by the p...... The neurotransmitter in the synaptic cleft released by the pre-synaptic neuron binds specific receptors located on the post-synaptic terminal. These receptors are either ion channels or G protein coupled receptors that function to transmit the signals from the post-synaptic membrane to the cell body. More...
REACT_21322	ionotropic activity_of_kainate_receptors	Kainate receptors are either Ca2+ permeable or impermeable d...... Kainate receptors are either Ca2+ permeable or impermeable depending on the composition of the receptor and the editing status of subunits GluR5 and GluR6 (GRIK1 and 2). More...

GRIK3 related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
GRIK3	FLNA	No	in vivo	11943148
GRIK3	GRIK5	Yes	in vivo	9466455

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways