MK4MDD

Environment Report

Basic Information
Name Stress
Description "The diathesis-stress model specifies that depression results when a preexisting vulnerability, or diathesis, is activated by stressful life events. In adulthood, stressful life events are strongly associated with the onset of major depressive episodes."
No. of Studies (Positive/Negative) 31(39/1) Help

Positive relationships between Stress and MDD (count: 7)
Name in Literature Reference Research Type Statistical Result Relation Description Help
stress Ravindran, 1996 patients and normal controls The response to a laboratory stressor was directly related t...... The response to a laboratory stressor was directly related to the severity of depression. More...
criticism Hooley, 2005 patients and normal controls Participants with a known vulnerability to depression respon...... Participants with a known vulnerability to depression respond differently to the psychosocial challenge of being criticized. More...
stress Krishnakumar, 2006 patients only Stress at school and in the family was significantly associa...... Stress at school and in the family was significantly associated with depressive disorder. More...
life stress Lethbridge, 2008 patients only Relapse was predicted by higher rates of life stress Relapse was predicted by higher rates of life stress
criticism Hooley, 2009 patients and normal controls Criticism may be a risk factor for relapse because it activa...... Criticism may be a risk factor for relapse because it activates the amygdala and perturbs the affective circuitry that underlies depression. More...
recent negative life stressors Hsu, 2010 patients and normal controls Significant effects of recent negative life stressors, but n...... Significant effects of recent negative life stressors, but not early life stress/trauma, were observed on regional blood oxygen level dependent activity during presentation of negative words in patients with MDD. More...
dependent stressful life events Kendler, 2010 patients and normal controls female (odds ratio [OR], 5.85) and male (4.55) in the entire sample; We found that dSLEs were strongly associated with risk for M...... We found that dSLEs were strongly associated with risk for MD in female (odds ratio [OR], 5.85) and male (4.55) twins in the entire sample and, at considerably lower levels, in female (2.29) and male (2.19) monozygotic twins discordant for dSLE exposure. A case-control sample matched on propensity score showed a moderate association in female (OR, 1.79) and male (1.53) twins. More...

Positive relationships between Stress and other components at different levels (count: 83) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of Stress in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Stress and MDD (count: 0)
Negative relationships between Stress and other components at different levels (count: 69) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment