MK4MDD

Study Report

Reference
CitationKedracka-Krok S, 2010 PubMed
Full InfoKedracka-Krok S, Fic E, Jankowska U, Jaciuk M, Gruca P, Papp M et al. Effect of chronic mild stress and imipramine on the proteome of the rat dentate gyrus. J Neurochem 2010; 113(4): 848-859.

Study
Hypothesis or Background The present study uses a proteomic approach to examine possible alterations of protein expression in the hippocampus of rats that are subjected to chronic mild stress (CMS)
Sample Informationmice
Method DetailThese rats serve as an animal model that was developed to mimic anhedonia, which is one of the core symptoms of depression. As antidepressant treatment is effective after a few weeks of administration, we also aimed to identify changes that were linked to chronic (once daily for 4 weeks) and 'pulse' (once a week) administration of imipramine. Fifteen differential proteins were identified with 2D electrophoresis followed by mass spectrometry
Method Keywordschronic mild stress (CMS); two-dimensional electrophoresis (2-DE); spectrophotometric analysis
ResultCMS-induced changes in the levels of dynactin 2, Ash 2, non-neuronal SNAP25 and alpha-enolase were reversed by chronic imipramine, but 'pulse' treatment was not that effective.

Relationships reported by Kedracka-Krok S, 2010

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
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Last update: October 10, 2015