MK4MDD

Symptoms Report

Basic Information
Name Anhedonia
Description "In psychology and psychiatry, anhedonia is defined as the inability to experience pleasure from activities formerly found enjoyable, e.g. hobbies, exercise, social interaction or sexual activity. As a clinical symptom in depression, anhedonia rates highly in making a diagnosis of this disorder. The Diagnostic and Statistical Manual of Mental Disorders (DSM) describes a ""lack of interest or pleasure"" but these can be hard to tell apart given that people become less interested in things which do not give them pleasure. The DSM criterion of weight loss is probably related to it and many depressed people with this symptom describe a lack of enjoyment of food. People suffering from anhedonia in association with depression generally feel good in the morning and unhappy in the evenings and can portray any of the non-psychotic symptoms and signs of depression."
No. of Studies (Positive/Negative) 34 (34/0) Help

Positive relationship between Anhedonia and MDD (count: 11)
Name in Literature Reference Research Type Statistical Result Relation Description Help
anhedonia Luby, 2003 normal people Anhedonia appeared to be a specific symptom and sadness/irri...... Anhedonia appeared to be a specific symptom and sadness/irritability appeared to be a sensitive symptom of preschool MDD. More...
anhedonic symptoms Joiner, 2003 patients only patients with major depression scored significantly higher o...... patients with major depression scored significantly higher on the anhedonic symptoms scale of the Beck Depression Inventory (BDI) than did patients with schizophrenia More...
anhedonia Lampe, 2004 patients and normal controls Significantly higher levels of apathy, anhedonia and psychom...... Significantly higher levels of apathy, anhedonia and psychomotor retardation, and worse performance on tests of executive function were found in the patient group compared with the healthy controls. More...
loss of pleasure Serretti, 2004 patients only The most frequently represented depressive symptoms in MDD w...... The most frequently represented depressive symptoms in MDD were Loss of energy/tiredness, Loss of pleasure, Poor concentration, and Sleep disorders. More...
anhedonia Wilcox, 2004 patients and normal controls The earliest and most frequently occurring forerunners of ad...... The earliest and most frequently occurring forerunners of adult-onset MDD were persistent depressed mood, anhedonia, feelings of worthlessness, and thoughts of death or suicide, with persistent anhedonia and worthlessness having a special prognostic value. More...
anhedonia Rapp, 2005 patients only The rates of anhedonia and comorbid cardiovascular illness w...... The rates of anhedonia and comorbid cardiovascular illness were higher in patients with late-onset geriatric major depressive disorder. More...
diminished interest in play and activities Krishnakumar, 2006 patients only Children with depressive disorder had significantly more fam...... Children with depressive disorder had significantly more family members affected with mental illnesses. The clinical features included diminished interest in play and activities, excessive tiredness, low self- esteem, problems with concentration, multiple somatic complaints, behavior symptoms like anger and aggression, recent deterioration in school performance and suicidal behavior. More...
anhedonia Fu, 2008 patients only 72.40% The most common depressive symptoms were: anhedonia (72.4%),...... The most common depressive symptoms were: anhedonia (72.4%), depressed mood (72.4%), decreased concentration (62.1%), and irritability (58.6%). More...
anhedonia Hurley, 2008 patients and normal controls Three symptoms were useful in differentiating depressed pati...... Three symptoms were useful in differentiating depressed patients from all other groups: sad mood, crying, and anhedonia. More...
diminished interest/pleasure Mitchell, 2009 patients only The prevalence of depression in our sample was 54.4%. In thi...... The prevalence of depression in our sample was 54.4%. In this high prevalence setting the optimum specific symptoms for ruling in MDD were psychomotor retardation, diminished interest/pleasure and indecisiveness. The most clinically valuable rule-out items were depressed mood, diminished interest/pleasure and poor concentration. More...
loss of libido Taylor, 2010 patients only P-value < .05 Decreased agitation, increased psychological anxiety, increa...... Decreased agitation, increased psychological anxiety, increased loss of appetite, increased loss of libido, and increased hypochondriasis were all risk factors for relapse and recurrence over a 2-year follow-up (all p<.05), after stratifying on number of previous episodes and controlling for age at onset and whether A-CT responders received continuation phase CT instead of assessment only control. More...

Positive relationships between Anhedonia and other components at different levels (count: 42) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of Anhedonia in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Anhedonia and MDD (count: 0)
Negative relationships between Anhedonia and other components at different levels (count: 0) Help