Molecule Report

Name	Glucose
Description	A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
MeSH ID	D005947
No. of Studies (Positive/Negative)	4(4/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
glucose	Drevets, 2002	patients only		At baseline, the mean glucose metabolism was increased in th...... At baseline, the mean glucose metabolism was increased in the left and right lateral orbital cortex/ventrolateral prefrontal cortex (PFC), left amygdala, and posterior cingulate cortex, and decreased in the subgenual ACC and dorsal medial/dorsal anterolateral PFC in the unmedicated depressives relative to controls. More...
glucose	Saxena, 2003	patients only		improvement of major depressive disorder symptoms was signif...... improvement of major depressive disorder symptoms was significantly correlated with lower pretreatment (glucose) metabolism in the amygdala (partial r=0.71) and thalamus (partial r=0.34) and with higher pretreatment (glucose) metabolism in the medial prefrontal cortex and rostral anterior cingulate gyrus (Talairach coordinates: x=0, y=62, z=10) (z=2.91). More...
glucose	Aihara, 2007	patients only		These results indicate that depressed patients remitted with...... These results indicate that depressed patients remitted with antidepressant treatment were accompanied by resolution of HPA dysregulation and alteration of regional glucose metabolism in the prefrontal cortical, limbic and paralimbic regions. More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
glucose		Amygdala(amygdala)	brain morphology and function	Saxena, 2003	patients only		improvement of major depressive disorder symptoms was signif...... improvement of major depressive disorder symptoms was significantly correlated with lower pretreatment (glucose) metabolism in the amygdala (partial r=0.71) More...
glucose		medial prefrontal cortex (MPFC)(medial prefrontal cortex)	brain morphology and function	Saxena, 2003	patients only		improvement of major depressive disorder symptoms was signif...... improvement of major depressive disorder symptoms was significantly correlated with higher pretreatment (glucose) metabolism in the medial prefrontal cortex and rostral anterior cingulate gyrus (Talairach coordinates: x=0, y=62, z=10) (z=2.91). More...
glucose		rostral anterior cingulate(rostral anterior cingulate gyrus)	brain morphology and function	Saxena, 2003	patients only		improvement of major depressive disorder symptoms was signif...... improvement of major depressive disorder symptoms was significantly correlated with higher pretreatment (glucose) metabolism in the medial prefrontal cortex and rostral anterior cingulate gyrus (Talairach coordinates: x=0, y=62, z=10) (z=2.91). More...
glucose		Thalamus(thalamus)	brain morphology and function	Saxena, 2003	patients only		improvement of major depressive disorder symptoms was signif...... improvement of major depressive disorder symptoms was significantly correlated with lower pretreatment (glucose) metabolism in the thalamus (partial r=0.34) More...
glucose		Anhedonia(anhedonia)	symptoms	Pizzagalli, 2004	patients and normal controls		Melancholia--a subtype of depression characterized by anhedo...... Melancholia--a subtype of depression characterized by anhedonia-- was associated with reduced activity in the subgenual PFC, manifested by decreased glucose metabolism. More...

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