MK4MDD

Brain Morphology and Function Report

Basic Information
Name Thalamus
Brain Morphology "The thalamus is the largest structure in the diencephalon, the part of the brain situated between the midbrain and forebrain. Anatomically, the thalamus is perched on top of the brainstem, near the center of the brain, in a position to send nerve fibers out to the cerebral cortex in all directions. "
Brain Function "Its function includes relaying sensation, spatial sense, and motor signals to the cerebral cortex, along with the regulation of consciousness, sleep, and alertness."
Picture Thalamus From Wiki. Magnify
No. of Studies (Positive/Negative) 23(23/0) Help

Positive relationships between Thalamus and MDD (count: 17)
Name in Literature Reference Research Type Statistical Result Relation Description Help
thalamus Mitterschiffthaler, 2003 patients and normal controls Patients, compared to controls, showed increased activation ...... Patients, compared to controls, showed increased activation in thalamus. More...
thalamus Costafreda, 2009 patients and normal controls Decreased grey matter density in the thalamus showed the hig...... Decreased grey matter density in the thalamus showed the highest contribution to the diagnosis of depression. More...
thalamus Alexopoulos, 2009 patients only Depressed elders (N=27) had lower FA (fractional anisotropy)...... Depressed elders (N=27) had lower FA (fractional anisotropy) than controls (N=27) in several frontolimbic areas, including the thalamus More...
thalamus Saxena, 2001 patients and normal controls Thalamic metabolism was significantly elevated in OCD alone ...... Thalamic metabolism was significantly elevated in OCD alone and in MDD alone. More...
thalamus Ichimiya, 2002 patients and normal controls Subgroup comparison showed that MDD patients had significant...... Subgroup comparison showed that MDD patients had significantly higher binding potential in the thalamus compared to control subjects. Functional abnormality in the thalamus may be involved in the pathophysiology of mood disorders. More...
thalamus Saxena, 2003 patients only partial r=0.34 improvement of major depressive disorder symptoms was signif...... improvement of major depressive disorder symptoms was significantly correlated with lower pretreatment (glucose) metabolism in the thalamus (partial r=0.34) More...
thalamus Holthoff, 2004 patients only There were significant decreases in metabolism upon remissio...... There were significant decreases in metabolism upon remission with respect to the baseline scan in left prefrontal, anterior temporal and anterior cingulate cortex and bilateral thalamus (SPM analysis) and bilateral putamen and cerebellum (SPM and ROI analyses). More...
thalamic structures Milak, 2005 patients only Total HDRS(Hamilton Depression Rating Scale) score correlate...... Total HDRS(Hamilton Depression Rating Scale) score correlated positively with activity in a large bilateral ventral cortical and subcortical region that included limbic, thalamic, and basal ganglia structures. More...
thalamus Greicius, 2007 patients and normal controls Resting-state subgenual cingulate and thalamic functional co...... Resting-state subgenual cingulate and thalamic functional connectivity with the default-mode network were significantly greater in the depressed subjects. More...
thalamus Cannon, 2007 patients and normal controls increased 5-HTT BP in the thalamus (24%) Relative to the healthy group both MDD and BD groups showed ...... Relative to the healthy group both MDD and BD groups showed significantly increased 5-HTT BP in the thalamus (24%, 14%, respectively) More...
thalamus Johnstone, 2007 patients and normal controls Pupil dilation data suggest that those depressed patients wh...... Pupil dilation data suggest that those depressed patients who expend more effort to reappraise negative stimuli are characterized by accentuated activation in the thalamus, whereas nondepressed individuals exhibit the opposite pattern. More...
thalamus Vasic, 2008 patients and normal controls Patients with depression showed reduced gray matter volume (...... Patients with depression showed reduced gray matter volume (GMV) was found in the thalamus. More...
adhesio interthalamica Takahashi, 2009 patients and normal controls The currently depressed patients had a significantly shorter...... The currently depressed patients had a significantly shorter AI (interthalamica) compared with controls More...
thalamus Selvaraj, 2011 patients and normal controls The depressed patients had lowered 5-HTT binding in several ...... The depressed patients had lowered 5-HTT binding in several brain regions including thalamus More...
thalamus Deschwanden, 2011 patients and normal controls The PET study revealed lower levels of regional mGluR5 bindi...... The PET study revealed lower levels of regional mGluR5 binding in the prefrontal cortex, the cingulate cortex, the insula, the thalamus, and the hippocampus in the depression group relative to the comparison group. More...
thalami Lee, 2011 patients and normal controls Decreased gray matter concentration was found in MDD patient...... Decreased gray matter concentration was found in MDD patients in the bilateral amygdalae, hippocampi, fusiform gyri, lingual gyri, insular gyri, middle-superior temporal gyri, thalami, cingulate gyri, the central lobule of the cerebellum, and the midbrain encompassing the dorsal raphe nuclei (DRN) More...
thalamus Richieri, 2011 patients only uncorrected P-value < 0.001 In comparison to responders, non-responders showed significa...... In comparison to responders, non-responders showed significant hypoperfusions (p < 0.001, uncorrected) in the right thalamus. More...

Positive relationships between Thalamus and other components at different levels (count: 13) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of Thalamus in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Thalamus and MDD (count: 0)
Negative relationships between Thalamus and other components at different levels (count: 0) Help