Study Report
Reference
| Citation | Selvaraj, 2011 PubMed |
| Full Info | Selvaraj, S., Murthy, N.V., Bhagwagar, Z., Bose, S.K., Hinz, R., Grasby, P.M. and Cowen, P.J. (2011) Diminished brain 5-HT transporter binding in major depression: a positron emission tomography study with [11C]DASB. Psychopharmacology (Berl), 213, 555-562.
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Study
| Hypothesis or Background |
The serotonin transporter (5-HTT) plays a critical role in the regulation of serotonin neurotransmission and has been implicated in the pathophysiology of major depression. In a previous positron emission tomography study, we found no difference in brain 5-HTT binding between unmedicated recovered depressed patients and healthy controls. AIM: This study aims to assess brain 5-HTT binding in a group of unmedicated acutely depressed patients in comparison to healthy controls.
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| Sample Information | 12 medication-free depressed patients with a mean duration of illness of about 1 year and 24 healthy controls. |
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| Method Detail | We studied 5-HTT binding using [(11)C]DASB in conjunction with positron emission tomography in 12 medication-free depressed patients with a mean duration of illness of about 1 year and 24 healthy controls. |
| Method Keywords | positron emission tomography (PET) |
| Result | The depressed patients had lowered 5-HTT binding in several brain regions including brain stem, thalamus, caudate, putamen, anterior cingulate cortex and frontal cortex. |
| Conclusions | These results suggest that diminished availability of the 5-HTT in the brain may be a state marker of acute depression. Alternatively, low 5-HTT binding may delineate a group of depressed patients with a poor long-term prognosis. |
Relationships reported by
Selvaraj, 2011
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
Sodium-dependent serotonin transporter (serotonin transporter (5-HTT)) |
protein |
|
The depressed patients had lowered 5-HTT binding in several brain regions including brain stem, thalamus, caudate, putamen, anterior cingulate cortex and frontal cortex. |
Positive
|
|
MDD
|
syndrome |
Thalamus (thalamus) |
brain morphology and function |
|
The depressed patients had lowered 5-HTT binding in several brain regions including thalamus |
Positive
|
|
MDD
|
syndrome |
Putamen (putamen) |
brain morphology and function |
|
The depressed patients had lowered 5-HTT binding in several brain regions including putamen |
Positive
|
|
MDD
|
syndrome |
Fronto-parietal connection (frontal cortex) |
brain morphology and function |
|
The depressed patients had lowered 5-HTT binding in several brain regions including frontal cortex. |
Positive
|
|
MDD
|
syndrome |
Caudate nucleus (caudate) |
brain morphology and function |
|
The depressed patients had lowered 5-HTT binding in several brain regions including caudate |
Positive
|
|
MDD
|
syndrome |
Brainstem (brain stem) |
brain morphology and function |
|
The depressed patients had lowered 5-HTT binding in several brain regions including brain stem |
Positive
|
|
MDD
|
syndrome |
Anterior cingulate cortex (anterior cingulate cortex) |
brain morphology and function |
|
The depressed patients had lowered 5-HTT binding in several brain regions including anterior cingulate cortex |
Positive
|
