MK4MDD

Brain Morphology and Function Report

Basic Information
Name Putamen
Brain Morphology "The putamen is a round structure located at the base of the forebrain (telencephalon). The putamen and caudate nucleus together form the dorsal striatum. It is also one of the structures that comprises the basal ganglia. Through various pathways, the putamen is connected to the substantia nigra and globus pallidus. "
Brain Function The main function of the putamen is to regulate movements and influence various types of learning. It employs dopamine to perform its functions.
Picture Putamen Source Magnify
No. of Studies (Positive/Negative) 17(17/0) Help

Positive relationships between Putamen and MDD (count: 10)
Name in Literature Reference Research Type Statistical Result Relation Description Help
putamen Mitterschiffthaler, 2003 patients and normal controls Patients, compared to controls, showed increased activation ...... Patients, compared to controls, showed increased activation in putamen. More...
putamen Tupler, 2002 patients and normal controls Late- and early-onset patients had more severe subcortical g...... Late- and early-onset patients had more severe subcortical gray-matter hyperintensities (particularly in the putamen) compared with controls. More...
putamen Vythilingam, 2003 patients and normal controls Compared with control subjects, MDD patients had a significa...... Compared with control subjects, MDD patients had a significantly lower mean NAA/Cr amplitude in the caudate and a significantly higher mean Cho/Cr amplitude in the putamen, particularly on the right side. More...
putamen Kumar, 2004 patients and normal controls Patients had significantly lower MTRs(Magnetization transfer...... Patients had significantly lower MTRs(Magnetization transfer ratios) in the genu and splenium of the corpus callosum, the right caudate nucleus and putamen, and the occipital white matter compared with controls. More...
putamen Holthoff, 2004 patients only There were significant decreases in metabolism upon remissio...... There were significant decreases in metabolism upon remission with respect to the baseline scan in left prefrontal, anterior temporal and anterior cingulate cortex and bilateral thalamus (SPM analysis) and bilateral putamen and cerebellum (SPM and ROI analyses). More...
putamen Ende, 2007 patients and normal controls Significantly lower choline-containing compounds in the hipp...... Significantly lower choline-containing compounds in the hippocampus and significantly higher choline-containing compounds in the putamen of patients with MDD compared to healthy subjects were found. More...
putamen Remijnse, 2009 patients and normal controls Imaging results showed MDD-specific hyperactivity in the ant...... Imaging results showed MDD-specific hyperactivity in the anterior insula during punishment processing and in the putamen during reward processing. More...
putamen Halari, 2009 patients and normal controls Adolescents with depression compared to healthy controls dem...... Adolescents with depression compared to healthy controls demonstrated reduced activation in putamen, insula and temporal lobes during the Switch task. More...
putamen Selvaraj, 2011 patients and normal controls The depressed patients had lowered 5-HTT binding in several ...... The depressed patients had lowered 5-HTT binding in several brain regions including putamen More...
putamen Gotlib, 2010 high-risk people and normal controls high-risk participants showed less activation than did their...... high-risk participants showed less activation than did their low-risk counterparts in the putamen More...

Positive relationships between Putamen and other components at different levels (count: 10) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of Putamen in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Putamen and MDD (count: 0)
Negative relationships between Putamen and other components at different levels (count: 0) Help