Study Report

CitationEnde, 2007 PubMed
Full InfoEnde, G., Demirakca, T., Walter, S., Wokrina, T., Sartorius, A., Wildgruber, D. and Henn, F.A. (2007) Subcortical and medial temporal MR-detectable metabolite abnormalities in unipolar major depression. Eur Arch Psychiatry Clin Neurosci, 257, 36-39.

Hypothesis or Background The purpose of the present study was to determine whether MR-detectable alterations of choline-containing compounds in two key neural systems involved in major depression disorder namely the hippocampus and the basal ganglia can be detected.
Sample Information11 patients with major depressive disorder (MDD) and ten matched healthy subjects
Method DetailMultislice proton magnetic resonance spectroscopic imaging was applied in 11 patients with major depressive disorder (MDD) and ten matched healthy subjects. Voxels were selected from the left and right side of the hippocampus and the putamen.
Method Keywordsspectrophotometric analysis
ResultSignificantly lower choline-containing compounds in the hippocampus and significantly higher choline-containing compounds in the putamen of patients with MDD compared to healthy subjects were found. No significant differences were found for the other metabolites in the two regions evaluated. Abnormal levels of choline-containing compounds most likely reflect altered membrane phospholipid metabolism.

Relationships reported by Ende, 2007