MK4MDD

Gene Report

Basic Information
Approved Symbol CNR1
Approved Name cannabinoid receptor 1 (brain)
Previous Symbol CNR
Symbol Alias CB1K5, CB-R, CB1, CANN6, CB1A
Location 6q14-q15
Position chr6:88875522-88875767 (-)
External Links Entrez Gene: 1268
Ensembl: ENSG00000118432
UCSC: uc003pmq.4
HGNC ID: 2159
No. of Studies (Positive/Negative) 4(3/1) Help
Type Literature-origin; SNP mapped; Protein mapped

Positive relationships between CNR1 and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description Help
CNR1 Monteleone, 2010 patients and normal controls chi(2)=12.595; df=4, P-value=0.01 for genotyP-valuees; chi(2)=13.773; df=2, P-value=0.001 for alleles The distribution of the CNR1 1359 G/A genotypes and alleles ...... The distribution of the CNR1 1359 G/A genotypes and alleles significantly differed among the groups (chi(2)=12.595; df=4, P=0.01 for genotypes; chi(2)=13.773; df=2, P=0.001 for alleles) with MD patients showing a higher frequency of both AG, GG genotypes and A allele as compared to healthy controls. More...

Positive relationships between CNR1 and other components at different levels (count: 6) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of CNR1 in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between CNR1 and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description
CNR1 Byrne EM, 2014 Patients and nomal controls P-Values=0.12 These results show that while there are several circadian ge...... These results show that while there are several circadian genes that harbor SNPs with nominally significant P-values, there are no associations beyond what would be expected after controlling for the number of SNPs in each gene. The gene-based test not only controls for the number of SNPs, but also combines evidence from multiple SNPs after controlling for the linkage disequilibrium between them More...

Negative relationships between CNR1 and other components at different levels (count: 0) Help
CNR1 related SNPs in MK4MDD (count: 1)
CNR1 related proteins in MK4MDD (count: 1)
CNR1 related GO terms (count: 40)
CNR1 related KEGG pathways (count: 1)
CNR1 related BioCarta pathways (count: 0)
CNR1 related Reactome pathways (count: 4)
CNR1 related interactors from protein-protein interaction data in HPRD (count: 6)