Gene Report

Basic Information

Approved Symbol	CNR1
Approved Name	cannabinoid receptor 1 (brain)
Previous Symbol	CNR
Symbol Alias	CB1K5, CB-R, CB1, CANN6, CB1A
Location	6q14-q15
Position	chr6:88849583-88875767 (-)
External Links	Entrez Gene: 1268 Ensembl: ENSG00000118432 UCSC: uc003pmq.4 HGNC ID: 2159
No. of Studies (Positive/Negative)	3(3/0)
Type	Literature-origin; SNP mapped; Protein mapped

Positive relationships between CNR1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
CNR1	Monteleone, 2010	patients and normal controls	chi(2)=12.595; df=4, P-value=0.01 for genotyP-valuees; chi(2)=13.773; df=2, P-value=0.001 for alleles	The distribution of the CNR1 1359 G/A genotypes and alleles ...... The distribution of the CNR1 1359 G/A genotypes and alleles significantly differed among the groups (chi(2)=12.595; df=4, P=0.01 for genotypes; chi(2)=13.773; df=2, P=0.001 for alleles) with MD patients showing a higher frequency of both AG, GG genotypes and A allele as compared to healthy controls. More...

Positive relationships between CNR1 and other components at different levels (count: 6)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Relation Description
Name in Literature	Related Components
Cnr1		SLC17A7(vesicular glutamate transporter 1 (VGLUT1))	gene	Tordera RM, 2011	animal model	gene was regulated in frontal cortex of VGLUT1(+/-) mice gene was regulated in frontal cortex of VGLUT1(+/-) mice
cannabinoid receptor 1 gene (CNR1)		Amygdala(amygdala)	brain morphology and function	Domschke, 2008	patients only	CNR1 rs1049353 G allele carriers also demonstrated weaker bi...... CNR1 rs1049353 G allele carriers also demonstrated weaker bilateral amygdala, putamen and pallidum activity as well as left lateralized caudate and thalamus activity in response to masked happy faces. More...
cannabinoid receptor 1 gene (CNR1)		Caudate nucleus(caudate)	brain morphology and function	Domschke, 2008	patients only	CNR1 rs1049353 G allele carriers also demonstrated weaker bi...... CNR1 rs1049353 G allele carriers also demonstrated weaker bilateral amygdala, putamen and pallidum activity as well as left lateralized caudate and thalamus activity in response to masked happy faces. More...
cannabinoid receptor 1 gene (CNR1)		Globus pallidus(pallidum)	brain morphology and function	Domschke, 2008	patients only	CNR1 rs1049353 G allele carriers also demonstrated weaker bi...... CNR1 rs1049353 G allele carriers also demonstrated weaker bilateral amygdala, putamen and pallidum activity as well as left lateralized caudate and thalamus activity in response to masked happy faces. More...
cannabinoid receptor 1 gene (CNR1)		Putamen(putamen)	brain morphology and function	Domschke, 2008	patients only	CNR1 rs1049353 G allele carriers also demonstrated weaker bi...... CNR1 rs1049353 G allele carriers also demonstrated weaker bilateral amygdala, putamen and pallidum activity as well as left lateralized caudate and thalamus activity in response to masked happy faces. More...
cannabinoid receptor 1 gene (CNR1)		Thalamus(thalamus)	brain morphology and function	Domschke, 2008	patients only	CNR1 rs1049353 G allele carriers also demonstrated weaker bi...... CNR1 rs1049353 G allele carriers also demonstrated weaker bilateral amygdala, putamen and pallidum activity as well as left lateralized caudate and thalamus activity in response to masked happy faces. More...

Positive relationship network of CNR1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between CNR1 and MDD (count: 0)

Negative relationships between CNR1 and other components at different levels (count: 0)

CNR1 related SNPs in MK4MDD (count: 1)

#rs	Location	Annotation	No. of Studies (Positive/Negative)
rs1049353	chr6:88853635(Forward)	3_prime_UTR_variant; downstream_gene_variant; synonymous_variant	1(1/0)

CNR1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Cannabinoid receptor 1	P21554	1(1/0)	Literature-origin

CNR1 related GO terms (count: 35)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0006950	response to stress	biological process	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0051966	regulation of synaptic transmission, glutamatergic	biological process	IEA
GO:0045776	negative regulation of blood pressure	biological process	IEA
GO:0060259	regulation of feeding behavior	biological process	IEA
GO:0005886	plasma membrane	cellular component	TAS
GO:0007568	aging	biological process	IEA
GO:0010976	positive regulation of neuron projection development	biological process	IEA
GO:0060405	regulation of penile erection	biological process	IEA
GO:0051001	negative regulation of nitric-oxide synthase activity	biological process	IEA
GO:0045777	positive regulation of blood pressure	biological process	IEA
GO:0031999	negative regulation of fatty acid beta-oxidation	biological process	IEA
GO:0008144	drug binding	molecular function	IEA
GO:0004949	cannabinoid receptor activity	molecular function	IDA[18761332]
GO:0033602	negative regulation of dopamine secretion	biological process	IEA
GO:0007283	spermatogenesis	biological process	IEA
GO:0043278	response to morphine	biological process	IEA
GO:0032228	regulation of synaptic transmission, GABAergic	biological process	IEA
GO:0045759	negative regulation of action potential	biological process	IEA
GO:0007613	memory	biological process	IEA
GO:0042220	response to cocaine	biological process	IEA
GO:0033004	negative regulation of mast cell activation	biological process	IEA
GO:0043065	positive regulation of apoptotic process	biological process	IEA
GO:0050796	regulation of insulin secretion	biological process	IEA
GO:0045471	response to ethanol	biological process	IEA
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	biological process	TAS[1718258]
GO:0032496	response to lipopolysaccharide	biological process	IEA
GO:0005887	integral to plasma membrane	cellular component	TAS[1718258]
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	biological process	IDA[18761332]
GO:0060135	maternal process involved in female pregnancy	biological process	IEA
GO:0019233	sensory perception of pain	biological process	IEA
GO:0035094	response to nicotine	biological process	IEA
GO:0007584	response to nutrient	biological process	IEA
GO:0002866	positive regulation of acute inflammatory response to antigenic stimulus	biological process	IEA
GO:0031622	positive regulation of fever generation	biological process	IEA
GO:0007610	behavior	biological process	TAS[1718258]

CNR1 related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa04080	neuroactive ligand_receptor_interaction	Neuroactive ligand-receptor interaction

CNR1 related BioCarta pathways (count: 0)

CNR1 related Reactome pathways (count: 4)

ID	Name	Description
Gene mapped Reactome pathways
REACT_14828	class a1_rhodopsin_like_receptors	Rhodopsin-like receptors. They represent members which inclu...... Rhodopsin-like receptors. They represent members which include hormone, light and neurotransmitter receptors and encompass a wide range of functions including many autocrine, paracrine and endocrine processes. More...
REACT_21340	gpcr ligand_binding	There are more than 800 G-protein coupled receptor. GPCRs ar...... There are more than 800 G-protein coupled receptor. GPCRs are receptors for a diverse range of ligands from large proteins to photons and have an equal diverstiy of ligand-binding mechanisms. Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. More...
REACT_19231	g alpha_i_signalling_events	The classical signalling mechanism for G alpha (i) is inhibi...... The classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased activity of cAMP-dependent protein kinases. More...
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...

CNR1 related interactors from protein-protein interaction data in HPRD (count: 6)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
CNR1	GNAI3	No	in vivo	11168387
CNR1	GNAI1	No	in vivo	11168387
CNR1	GNAI2	No	in vivo	11168387
CNR1	MET	No	in vitro	11894096
CNR1	HCRTR1	Yes	in vivo	12690115
CNR1	GNA15	No	in vivo	12095632

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways