Gene Report

Basic Information

Approved Symbol	HCRTR1
Approved Name	hypocretin (orexin) receptor 1
Symbol Alias	OX1R
Location	1p33
Position	chr1:32092947-32093214 (+)
External Links	Entrez Gene: 3061 Ensembl: ENSG00000121764 UCSC: uc009vtx.2 HGNC ID: 4848
No. of Studies (Positive/Negative)	2(2/0)
Type	Literature-origin; SNP mapped

Positive relationships between HCRTR1 and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
HCRTR1	Rainero I, 2011	Patients and nomal controls	p<0.0001	we found a significant association between HCRTR1 haplotype...... we found a significant association between HCRTR1 haplotypes and the disease (permutation p<0.0001) More...
Orexin A	Rotter, 2011	patients and normal controls	T=1.53; df=39; P-value=0.135	There was a measurable difference between Orexin A expressio...... There was a measurable difference between Orexin A expression on admission in comparison to the Orexin mRNA expression in the healthy control group (T=1.53; df=39; p=0.135) that failed to reach statistical significance. More...

Positive relationships between HCRTR1 and other components at different levels (count: 5)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description
Name in Literature	Related Components
Orexin A		methylation-HCRT-21211849-1(methylation-HCRT-21211849-1)	epigenetic site	Rotter, 2011	patients and nomal controls	r=0.471; p=0.042	Furthermore, this methylation pattern on day 28 was positive...... Furthermore, this methylation pattern on day 28 was positively associated with mRNA expression on day 0, day 14 and day 28 of the examination (Delta CT Orexin A on day 0 and methylation on day 28: r=0.421; p=0.073; Delta CT Orexin on day 14: r=0.45; p=0.053; and Delta CT Orexin A on day 28: r=0.471; p=0.042) More...
Orexin A		methylation-HCRT-21211849-2(methylation-HCRT-21211849-2)	epigenetic site	Rotter, 2011	patients and nomal controls	r=0.471; p=0.042	Furthermore, this methylation pattern on day 28 was positive...... Furthermore, this methylation pattern on day 28 was positively associated with mRNA expression on day 0, day 14 and day 28 of the examination (Delta CT Orexin A on day 0 and methylation on day 28: r=0.421; p=0.073; Delta CT Orexin on day 14: r=0.45; p=0.053; and Delta CT Orexin A on day 28: r=0.471; p=0.042) More...
Orexin A		methylation-HCRT-21211849-3(methylation-HCRT-21211849-3)	epigenetic site	Rotter, 2011	patients and nomal controls	r=0.471; p=0.042	Furthermore, this methylation pattern on day 28 was positive...... Furthermore, this methylation pattern on day 28 was positively associated with mRNA expression on day 0, day 14 and day 28 of the examination (Delta CT Orexin A on day 0 and methylation on day 28: r=0.421; p=0.073; Delta CT Orexin on day 14: r=0.45; p=0.053; and Delta CT Orexin A on day 28: r=0.471; p=0.042) More...
Orexin A		methylation-HCRT-21211849-4(methylation-HCRT-21211849-4)	epigenetic site	Rotter, 2011	patients and nomal controls	r=0.471; p=0.042	Furthermore, this methylation pattern on day 28 was positive...... Furthermore, this methylation pattern on day 28 was positively associated with mRNA expression on day 0, day 14 and day 28 of the examination (Delta CT Orexin A on day 0 and methylation on day 28: r=0.421; p=0.073; Delta CT Orexin on day 14: r=0.45; p=0.053; and Delta CT Orexin A on day 28: r=0.471; p=0.042) More...
Orexin A		methylation-HCRT-21211849-5(methylation-HCRT-21211849-5)	epigenetic site	Rotter, 2011	patients and nomal controls	r=0.471; p=0.042	Furthermore, this methylation pattern on day 28 was positive...... Furthermore, this methylation pattern on day 28 was positively associated with mRNA expression on day 0, day 14 and day 28 of the examination (Delta CT Orexin A on day 0 and methylation on day 28: r=0.421; p=0.073; Delta CT Orexin on day 14: r=0.45; p=0.053; and Delta CT Orexin A on day 28: r=0.471; p=0.042) More...

Positive relationship network of HCRTR1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between HCRTR1 and MDD (count: 0)

Negative relationships between HCRTR1 and other components at different levels (count: 0)

HCRTR1 related SNPs in MK4MDD (count: 1)

#rs	Location	Annotation	No. of Studies (Positive/Negative)
rs2271933	chr1:31626924(Forward)	regulatory_region_variant	1(1/0)

HCRTR1 related proteins in MK4MDD (count: 0)

HCRTR1 related GO terms (count: 13)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0007268	synaptic transmission	biological process	TAS[9491897]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0017046	peptide hormone binding	molecular function	IEA
GO:0005886	plasma membrane	cellular component	TAS
GO:1901652	response to peptide	biological process	IBA
GO:0004930	G-protein coupled receptor activity	molecular function	TAS[9491897]
GO:0042277	peptide binding	molecular function	IBA
GO:0007218	neuropeptide signaling pathway	biological process	IEA
GO:0007631	feeding behavior	biological process	IEA
GO:0005887	integral component of plasma membrane	cellular component	TAS[9491897]
GO:0016499	orexin receptor activity	molecular function	IBA
GO:0032870	cellular response to hormone stimulus	biological process	IBA
GO:0045187	regulation of circadian sleep/wake cycle, sleep	biological process	IBA
GO:0008188	neuropeptide receptor activity	molecular function	IBA

HCRTR1 related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa04080	neuroactive ligand_receptor_interaction	Neuroactive ligand-receptor interaction

HCRTR1 related BioCarta pathways (count: 0)

HCRTR1 related Reactome pathways (count: 5)

ID	Name	Description
Gene mapped Reactome pathways
REACT_21340	gpcr ligand_binding	There are more than 800 G-protein coupled receptor. GPCRs ar...... There are more than 800 G-protein coupled receptor. GPCRs are receptors for a diverse range of ligands from large proteins to photons and have an equal diverstiy of ligand-binding mechanisms. Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. More...
REACT_14828	class a1_rhodopsin_like_receptors	Rhodopsin-like receptors. They represent members which inclu...... Rhodopsin-like receptors. They represent members which include hormone, light and neurotransmitter receptors and encompass a wide range of functions including many autocrine, paracrine and endocrine processes. More...
REACT_18283	g alpha_q_signalling_events	The classic signalling route for G alpha (q) is activation o...... The classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides a path to calcium-regulated kinases and phosphatases, GEFs, MAP kinase cassettes and other proteins that mediate cellular responses ranging from granule secretion, integrin activation, and aggregation in platelets. Gq participates in many other signalling events including direct interaction with RhoGEFs that stimulate RhoA activity and inhibition of PI3K. Both in vitro and in vivo, the G-protein Gq seems to be the predominant mediator of the activation of platelets. More...
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...
REACT_14819	peptide ligand_binding_receptors	These receptors, a subset of the Class A/1 (Rhodopsin-like) ...... These receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins. More...

HCRTR1 related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
HCRTR1	HCRT	No	in vitro;in vivo	9491897
HCRTR1	CNR1	Yes	in vivo	12690115

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways