SNP Report

Name	rs2271933 dbSNP Ensembl
Location	Chrchr1:32092525(Forward)
Variant Alleles	A/G
Ancestral Allele	G
Annotation	downstream_gene_variant; intron_variant; missense_variant; nc_transcript_variant PolyPhen: benign(ENST00000373706, ENST00000403528) SIFT: tolerated(ENST00000373706, ENST00000403528)
Consequence to Transcript	downstream_gene_variant(ENST00000373703, ENST00000461006, ENST00000478502, ENST00000485464, ENST00000489164) intron_variant(ENST00000373705, ENST00000468521) missense_variant(ENST00000373706, ENST00000403528) nc_transcript_variant(ENST00000468521)
No. of Studies (Positive/Negative)	1 (1/0)

Reference	Research Type	Statistical Result	Relation Description
Rainero I, 2011	Patients and nomal controls	p=0.003;OR:1.60; 95% C.I. 1.22-2.10	We found that allelic and genotypic frequencies of the rs22...... We found that allelic and genotypic frequencies of the rs2271933 G>A polymorphism (Ile408Val) in the HCRTR1 gene were significantly different between cases and controls (p=0.003 and p=0.0004, respectively). The carriage of the A allele was associated with a significantly increased disease risk (OR:1.60, 95% C.I. 1.22-2.10). More...

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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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3. The network is generated using Cytoscape Web

Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
HCRTR1	hypocretin (orexin) receptor 1	Literature-origin; SNP mapped	2(2/0)
PEF1	penta-EF-hand domain containing 1	SNP mapped	0(0/0)