Reactome Pathway Report

Basic Information
Name g alpha_q_signalling_events
Description The classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides a path to calcium-regulated kinases and phosphatases, GEFs, MAP kinase cassettes and other proteins that mediate cellular responses ranging from granule secretion, integrin activation, and aggregation in platelets. Gq participates in many other signalling events including direct interaction with RhoGEFs that stimulate RhoA activity and inhibition of PI3K. Both in vitro and in vivo, the G-protein Gq seems to be the predominant mediator of the activation of platelets.

REACT_18283 related genes in MK4MDD (count: 30)
Approved Symbol Approved Name Type No. of Studies (Positive/Negative)
PROK2 prokineticin 2 Literature-origin 1(1/0)
NTSR2 neurotensin receptor 2 Literature-origin 1(1/0)
HCRTR1 hypocretin (orexin) receptor 1 Literature-origin; SNP mapped 2(2/0)
LPAR1 lysophosphatidic acid receptor 1 Literature-origin 2(2/0)
CCKAR cholecystokinin A receptor Literature-origin 1(1/0)
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 Protein mapped 0(0/0)
F2 coagulation factor II (thrombin) Protein mapped 0(0/0)
BDKRB1 bradykinin receptor B1 Protein mapped 0(0/0)
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Literature-origin; SNP mapped; Protein mapped 11(7/4)
OXT oxytocin/neurophysin I prepropeptide Protein mapped 0(0/0)
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) Literature-origin 1(1/0)
AVPR1B arginine vasopressin receptor 1B Literature-origin; Protein mapped 1(1/0)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 Literature-origin 2(2/0)
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 Literature-origin; SNP mapped 2(2/0)
BDKRB2 bradykinin receptor B2 SNP mapped 0(0/0)
CCKBR cholecystokinin B receptor Literature-origin 2(2/0)
PROKR2 prokineticin receptor 2 Literature-origin 1(1/0)
TAC1 tachykinin, precursor 1 Literature-origin; Protein mapped 2(2/0)
TRIO trio Rho guanine nucleotide exchange factor Literature-origin 1(1/0)
EDN1 endothelin 1 Literature-origin 1(1/0)
DGKG diacylglycerol kinase, gamma 90kDa Literature-origin 1(1/0)
HRH1 histamine receptor H1 Protein mapped 0(0/0)
OXTR oxytocin receptor Literature-origin 1(1/0)
DGKH diacylglycerol kinase, eta Literature-origin 2(1/1)
DGKA diacylglycerol kinase, alpha 80kDa Literature-origin 1(1/0)
ADRBK1 adrenergic, beta, receptor kinase 1 Protein mapped 0(0/0)
EDNRB endothelin receptor type B Literature-origin 1(1/0)
GNG3 guanine nucleotide binding protein (G protein), gamma 3 Literature-origin 1(1/0)
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Literature-origin; SNP mapped 4(3/1)
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Protein mapped 0(0/0)