MK4MDD

Reactome Pathway Report

Basic Information
ID
Name g alpha_q_signalling_events
Description The classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides a path to calcium-regulated kinases and phosphatases, GEFs, MAP kinase cassettes and other proteins that mediate cellular responses ranging from granule secretion, integrin activation, and aggregation in platelets. Gq participates in many other signalling events including direct interaction with RhoGEFs that stimulate RhoA activity and inhibition of PI3K. Both in vitro and in vivo, the G-protein Gq seems to be the predominant mediator of the activation of platelets.

REACT_18283 related genes in MK4MDD (count: 28)
Approved Symbol Approved Name Type No. of Studies (Positive/Negative)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 Literature-origin; SNP mapped 1(1/0)
HCRTR1 hypocretin (orexin) receptor 1 Literature-origin; SNP mapped 2(2/0)
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Literature-origin; SNP mapped; Protein mapped 9(7/2)
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Protein mapped 0(0/0)
AVPR1B arginine vasopressin receptor 1B Literature-origin; Protein mapped 1(1/0)
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 Literature-origin; SNP mapped 2(2/0)
EDN1 endothelin 1 Literature-origin 1(1/0)
CCKBR cholecystokinin B receptor Literature-origin 2(2/0)
LPAR2 lysophosphatidic acid receptor 2 SNP mapped 0(0/0)
TACR1 tachykinin receptor 1 SNP mapped 0(0/0)
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) Literature-origin 1(1/0)
DGKG diacylglycerol kinase, gamma 90kDa Literature-origin 1(1/0)
LPAR1 lysophosphatidic acid receptor 1 Literature-origin 1(1/0)
F2 coagulation factor II (thrombin) Protein mapped 0(0/0)
PROKR2 prokineticin receptor 2 Literature-origin 1(1/0)
PROK2 prokineticin 2 Literature-origin 1(1/0)
TRIO trio Rho guanine nucleotide exchange factor Literature-origin 1(1/0)
OXT oxytocin/neurophysin I prepropeptide Protein mapped 0(0/0)
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 Protein mapped 0(0/0)
DGKH diacylglycerol kinase, eta Literature-origin 1(1/0)
BDKRB2 bradykinin receptor B2 SNP mapped 0(0/0)
GNG3 guanine nucleotide binding protein (G protein), gamma 3 Literature-origin 1(1/0)
ADRBK1 adrenergic, beta, receptor kinase 1 Protein mapped 0(0/0)
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Literature-origin; SNP mapped 4(3/1)
BDKRB1 bradykinin receptor B1 Protein mapped 0(0/0)
TAC1 tachykinin, precursor 1 Literature-origin; Protein mapped 2(2/0)
HRH1 histamine receptor H1 Protein mapped 0(0/0)
CCKAR cholecystokinin A receptor Literature-origin 1(1/0)