Gene Report

Basic Information

Approved Symbol	PROK2
Approved Name	prokineticin 2
Symbol Alias	PK2, BV8, MIT1, KAL4
Name Alias	protein Bv8 homolog
Location	3p21.1
Position	chr3:71820806-71834357 (-)
External Links	Entrez Gene: 60675 Ensembl: ENSG00000163421 UCSC: uc003dpa.4 HGNC ID: 18455
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between PROK2 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
PROK2	Spijker, 2010	patients and normal controls		Based on LPS-stimulated blood gene expression using whole-ge...... Based on LPS-stimulated blood gene expression using whole-genome microarrays, this gene serves as a molecular signature of MDD More...

Positive relationships between PROK2 and other components at different levels (count: 0)

Positive relationship network of PROK2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between PROK2 and MDD (count: 0)

Negative relationships between PROK2 and other components at different levels (count: 0)

PROK2 related SNPs in MK4MDD (count: 0)

PROK2 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Prokineticin-2	Q9HC23	0(0/0)	Gene mapped

PROK2 related GO terms (count: 15)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0006954	inflammatory response	biological process	NAS[11259612]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0007204	elevation of cytosolic calcium ion concentration	biological process	TAS[12728244]
GO:0007623	circadian rhythm	biological process	IEA
GO:0005576	extracellular region	cellular component	TAS
GO:0007218	neuropeptide signaling pathway	biological process	IEA
GO:0007186	G-protein coupled receptor signaling pathway	biological process	NAS[11259612]
GO:0006935	chemotaxis	biological process	IDA[12604792]
GO:0000187	activation of MAPK activity	biological process	TAS[12728244]
GO:0043066	negative regulation of apoptotic process	biological process	IDA[12604792]
GO:0008283	cell proliferation	biological process	IDA[12604792]
GO:0045987	positive regulation of smooth muscle contraction	biological process	IDA[11259612]
GO:0001664	G-protein coupled receptor binding	molecular function	TAS[12728244]
GO:0001525	angiogenesis	biological process	IDA[12604792]
GO:0019233	sensory perception of pain	biological process	TAS[12728244]
GO:0007283	spermatogenesis	biological process	IMP[10580115]

PROK2 related KEGG pathways (count: 0)

PROK2 related BioCarta pathways (count: 0)

PROK2 related Reactome pathways (count: 5)

ID	Name	Description
Gene mapped Reactome pathways
REACT_14819	peptide ligand_binding_receptors	These receptors, a subset of the Class A/1 (Rhodopsin-like) ...... These receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins. More...
REACT_18283	g alpha_q_signalling_events	The classic signalling route for G alpha (q) is activation o...... The classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides a path to calcium-regulated kinases and phosphatases, GEFs, MAP kinase cassettes and other proteins that mediate cellular responses ranging from granule secretion, integrin activation, and aggregation in platelets. Gq participates in many other signalling events including direct interaction with RhoGEFs that stimulate RhoA activity and inhibition of PI3K. Both in vitro and in vivo, the G-protein Gq seems to be the predominant mediator of the activation of platelets. More...
REACT_21340	gpcr ligand_binding	There are more than 800 G-protein coupled receptor. GPCRs ar...... There are more than 800 G-protein coupled receptor. GPCRs are receptors for a diverse range of ligands from large proteins to photons and have an equal diverstiy of ligand-binding mechanisms. Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. More...
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...
REACT_14828	class a1_rhodopsin_like_receptors	Rhodopsin-like receptors. They represent members which inclu...... Rhodopsin-like receptors. They represent members which include hormone, light and neurotransmitter receptors and encompass a wide range of functions including many autocrine, paracrine and endocrine processes. More...

PROK2 related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped Reactome pathways