Gene Report

Basic Information

Approved Symbol	LPAR1
Approved Name	lysophosphatidic acid receptor 1
Previous Symbol	EDG2
Previous Name	"endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2"
Symbol Alias	edg-2, rec.1.3, vzg-1, Gpcr26, Mrec1.3, LPA1, GPR26
Location	9q
Position	chr9:113801150-113801523 (-)
External Links	Entrez Gene: 1902 Ensembl: ENSG00000198121 UCSC: uc004bfc.3 HGNC ID: 3166
No. of Studies (Positive/Negative)	2(2/0)
Type	Literature-origin

Positive relationships between LPAR1 and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
EDG2	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder
EDG2	Tomita H, 2013	patients and normal controls		GPLS genes significantly dysregulated in anterior cingulate ...... GPLS genes significantly dysregulated in anterior cingulate cortex by microarray More...

Positive relationships between LPAR1 and other components at different levels (count: 0)

Positive relationship network of LPAR1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between LPAR1 and MDD (count: 0)

Negative relationships between LPAR1 and other components at different levels (count: 0)

LPAR1 related SNPs in MK4MDD (count: 0)

LPAR1 related proteins in MK4MDD (count: 0)

LPAR1 related GO terms (count: 40)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0043197	dendritic spine	cellular component	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0060999	positive regulation of dendritic spine development	biological process	IEA
GO:0005886	plasma membrane	cellular component	IDA[19306925]; TAS
GO:0070915	lysophosphatidic acid receptor activity	molecular function	IDA[19306925]; IMP[9070858]
GO:0021554	optic nerve development	biological process	IEA
GO:0071453	cellular response to oxygen levels	biological process	IEA
GO:0030818	negative regulation of cAMP biosynthetic process	biological process	IEA
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway	biological process	IMP[19733258]
GO:0043025	neuronal cell body	cellular component	IEA
GO:0001965	G-protein alpha-subunit binding	molecular function	IEA
GO:0032060	bleb assembly	biological process	IEA
GO:0005887	integral component of plasma membrane	cellular component	ISS
GO:0005768	endosome	cellular component	IDA[19306925]
GO:0022038	corpus callosum development	biological process	IEA
GO:0008360	regulation of cell shape	biological process	ISS
GO:1904566	cellular response to 1-oleoyl-sn-glycerol 3-phosphate	biological process	IEA
GO:0035025	positive regulation of Rho protein signal transduction	biological process	ISS
GO:0030165	PDZ domain binding	molecular function	IEA
GO:0043410	positive regulation of MAPK cascade	biological process	ISS
GO:0007204	positive regulation of cytosolic calcium ion concentration	biological process	TAS[9804623]
GO:0005515	protein binding	molecular function	IPI[19306925]
GO:0071673	positive regulation of smooth muscle cell chemotaxis	biological process	IEA
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	biological process	IEP[12761501]
GO:0030139	endocytic vesicle	cellular component	IDA[19306925]
GO:0014003	oligodendrocyte development	biological process	IEA
GO:0009986	cell surface	cellular component	IDA[19306925]
GO:0010977	negative regulation of neuron projection development	biological process	ISS
GO:0007186	G-protein coupled receptor signaling pathway	biological process	TAS[8922387]
GO:0051496	positive regulation of stress fiber assembly	biological process	ISS
GO:0005829	cytosol	cellular component	IEA; IMP[19733258]; TAS[9804623]
GO:0000187	activation of MAPK activity	biological process	IEA
GO:0035727	lysophosphatidic acid binding	molecular function	IDA[9070858]
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	biological process	ISS
GO:0042552	myelination	biological process	IEA
GO:0021549	cerebellum development	biological process	IEA
GO:0004930	G-protein coupled receptor activity	molecular function	TAS[8922387]
GO:0060326	cell chemotaxis	biological process	IMP[19733258]
GO:0043065	positive regulation of apoptotic process	biological process	IEA
GO:0043198	dendritic shaft	cellular component	IEA
GO:0007202	activation of phospholipase C activity	biological process	IDA[19306925]

LPAR1 related KEGG pathways (count: 2)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04540	gap junction	Gap junction	Gap junctions contain intercellular channels that allow dire...... Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation. More...
hsa04080	neuroactive ligand_receptor_interaction	Neuroactive ligand-receptor interaction

LPAR1 related BioCarta pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped BioCarta pathways
AKAP13_PATHWAY	akap13 pathway	Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation	The A-kinase anchor protein 13 (AKAP13, also known as AKAP-L...... The A-kinase anchor protein 13 (AKAP13, also known as AKAP-LBC) is one of a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. AKAP13 is a splice variant of the oncogene Lbc. Alternative splicing of the AKAP13 gene results in at least 3 transcript variants encoding different isoforms containing a Dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. These splice variants contain a fragment that was originally identified as Ht31 which acts as a scaffolding protein to regulate the Rho signaling pathway and as protein kinase A-anchoring protein creating a coordination of these two signalling pathways. Diviani et al. found that in HEK293 cells LPA induced stimulation preferentially activates AKAP13 via G-alpha12. As yet targets for the anchored PKA have not been identified. AKAP13 and Rho do not appear to be phosphorylated by PKA. Diviani et al also found that the Lbc oncogene and protooncogene splice variant show higher activation and stress fiber localization. This appears to be a result of the presence of N terminal inhibitory sequences. A similar model of regulation has been proposed for Dbl and Vav. More...

LPAR1 related Reactome pathways (count: 5)

ID	Name	Description
Gene mapped Reactome pathways
REACT_14828	class a1_rhodopsin_like_receptors	Rhodopsin-like receptors. They represent members which inclu...... Rhodopsin-like receptors. They represent members which include hormone, light and neurotransmitter receptors and encompass a wide range of functions including many autocrine, paracrine and endocrine processes. More...
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...
REACT_21340	gpcr ligand_binding	There are more than 800 G-protein coupled receptor. GPCRs ar...... There are more than 800 G-protein coupled receptor. GPCRs are receptors for a diverse range of ligands from large proteins to photons and have an equal diverstiy of ligand-binding mechanisms. Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. More...
REACT_19231	g alpha_i_signalling_events	The classical signalling mechanism for G alpha (i) is inhibi...... The classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased activity of cAMP-dependent protein kinases. More...
REACT_18283	g alpha_q_signalling_events	The classic signalling route for G alpha (q) is activation o...... The classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides a path to calcium-regulated kinases and phosphatases, GEFs, MAP kinase cassettes and other proteins that mediate cellular responses ranging from granule secretion, integrin activation, and aggregation in platelets. Gq participates in many other signalling events including direct interaction with RhoGEFs that stimulate RhoA activity and inhibition of PI3K. Both in vitro and in vivo, the G-protein Gq seems to be the predominant mediator of the activation of platelets. More...

LPAR1 related interactors from protein-protein interaction data in HPRD (count: 4)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
LPAR1	ARHGEF12	No	in vitro;in vivo	15755723
LPAR1	SLC9A3R2	No	in vitro	16203867
LPAR1	ARHGEF11	No	in vitro;in vivo	15755723
LPAR1	GNAI3	No	in vitro	9600933

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped BioCarta pathways

Gene mapped Reactome pathways