KEGG Pathway Report

Basic Information

ID	hsa04540
Name	gap junction
Brief Description	Gap junction
Full Description	Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.

hsa04540 related genes in MK4MDD (count: 27)

Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
ITPR1	inositol 1,4,5-trisphosphate receptor, type 1	Literature-origin; SNP mapped	1(1/0)
HTR2A	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	Literature-origin; SNP mapped; Protein mapped	9(7/2)
TUBB	tubulin, beta class I	Protein mapped	0(0/0)
DRD1	dopamine receptor D1	Literature-origin; Protein mapped	2(2/0)
GNAI3	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	SNP mapped	0(0/0)
GRM1	glutamate receptor, metabotropic 1	Literature-origin; SNP mapped	2(2/0)
PRKCG	protein kinase C, gamma	SNP mapped	0(0/0)
TUBA1B	tubulin, alpha 1b	Protein mapped	0(0/0)
EGF	epidermal growth factor	Literature-origin; SNP mapped; Protein mapped	1(0/1)
NRAS	neuroblastoma RAS viral (v-ras) oncogene homolog	Protein mapped	0(0/0)
LPAR1	lysophosphatidic acid receptor 1	Literature-origin	1(1/0)
MAPK1	mitogen-activated protein kinase 1	Literature-origin	2(2/0)
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	Protein mapped	0(0/0)
ADCY7	adenylate cyclase 7	Literature-origin; SNP mapped	2(2/0)
ADCY8	adenylate cyclase 8 (brain)	Literature-origin	2(2/0)
ADCY3	adenylate cyclase 3	Literature-origin; SNP mapped	1(0/1)
TUBB1	tubulin, beta 1 class VI	Protein mapped	0(0/0)
TUBB3	tubulin, beta 3 class III	SNP mapped	0(0/0)
PRKCB	protein kinase C, beta	Protein mapped	0(0/0)
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	Literature-origin; SNP mapped	4(3/1)
GNAS	GNAS complex locus	Literature-origin	1(0/1)
PRKACB	protein kinase, cAMP-dependent, catalytic, beta	Protein mapped	0(0/0)
DRD2	dopamine receptor D2	Literature-origin; Protein mapped	4(3/1)
GRM5	glutamate receptor, metabotropic 5	Protein mapped	0(0/0)
HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	Protein mapped	0(0/0)
KRAS	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	Protein mapped	0(0/0)
ADCY9	adenylate cyclase 9	SNP mapped	0(0/0)