KEGG Pathway Report

Basic Information
ID hsa04540
Name gap junction
Brief Description Gap junction
Full Description Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.

hsa04540 related genes in MK4MDD (count: 26)
Approved Symbol Approved Name Type No. of Studies (Positive/Negative)
LPAR1 lysophosphatidic acid receptor 1 Literature-origin 2(2/0)
GNAS GNAS complex locus Literature-origin 1(0/1)
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Literature-origin; SNP mapped; Protein mapped 11(7/4)
HRAS Harvey rat sarcoma viral oncogene homolog Protein mapped 0(0/0)
CSNK1D casein kinase 1, delta Literature-origin 1(0/1)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 Literature-origin 2(2/0)
EGF epidermal growth factor Literature-origin; SNP mapped; Protein mapped 1(0/1)
TUBB tubulin, beta class I Protein mapped 0(0/0)
TUBA1B tubulin, alpha 1b Protein mapped 0(0/0)
TUBB1 tubulin, beta 1 class VI Protein mapped 0(0/0)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog Protein mapped 0(0/0)
DRD1 dopamine receptor D1 Literature-origin; Protein mapped 2(2/0)
MAPK1 mitogen-activated protein kinase 1 Literature-origin 2(2/0)
ADCY8 adenylate cyclase 8 (brain) Literature-origin 2(2/0)
ADCY7 adenylate cyclase 7 Literature-origin 2(2/0)
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 Literature-origin 1(1/0)
ADCY3 adenylate cyclase 3 Literature-origin 2(1/1)
KRAS Kirsten rat sarcoma viral oncogene homolog Protein mapped 0(0/0)
PRKACB protein kinase, cAMP-dependent, catalytic, beta Protein mapped 0(0/0)
GRM5 glutamate receptor, metabotropic 5 Protein mapped 0(0/0)
DRD2 dopamine receptor D2 Literature-origin; Protein mapped 5(3/2)
PRKACA protein kinase, cAMP-dependent, catalytic, alpha Protein mapped 0(0/0)
PRKCB protein kinase C, beta Literature-origin; Protein mapped 1(1/0)
GRM1 glutamate receptor, metabotropic 1 Literature-origin 2(2/0)
PRKCG protein kinase C, gamma SNP mapped 0(0/0)
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Literature-origin; SNP mapped 4(3/1)