KEGG Pathway Report
Basic Information
| ID |
hsa04540
|
| Name |
gap junction
|
| Brief Description |
Gap junction
|
| Full Description |
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation. |
hsa04540 related genes in MK4MDD (count: 26)
| Approved Symbol |
Approved Name |
Type |
No. of Studies (Positive/Negative) |
| LPAR1 |
lysophosphatidic acid receptor 1 |
Literature-origin
|
2(2/0) |
| GNAS |
GNAS complex locus |
Literature-origin
|
1(0/1) |
| HTR2A |
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled |
Literature-origin; SNP mapped; Protein mapped
|
11(7/4) |
| HRAS |
Harvey rat sarcoma viral oncogene homolog |
Protein mapped
|
0(0/0) |
| CSNK1D |
casein kinase 1, delta |
Literature-origin
|
1(0/1) |
| ITPR1 |
inositol 1,4,5-trisphosphate receptor, type 1 |
Literature-origin
|
2(2/0) |
| EGF |
epidermal growth factor |
Literature-origin; SNP mapped; Protein mapped
|
1(0/1) |
| TUBB |
tubulin, beta class I |
Protein mapped
|
0(0/0) |
| TUBA1B |
tubulin, alpha 1b |
Protein mapped
|
0(0/0) |
| TUBB1 |
tubulin, beta 1 class VI |
Protein mapped
|
0(0/0) |
| NRAS |
neuroblastoma RAS viral (v-ras) oncogene homolog |
Protein mapped
|
0(0/0) |
| DRD1 |
dopamine receptor D1 |
Literature-origin; Protein mapped
|
2(2/0) |
| MAPK1 |
mitogen-activated protein kinase 1 |
Literature-origin
|
2(2/0) |
| ADCY8 |
adenylate cyclase 8 (brain) |
Literature-origin
|
2(2/0) |
| ADCY7 |
adenylate cyclase 7 |
Literature-origin
|
2(2/0) |
| GNAI1 |
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 |
Literature-origin
|
1(1/0) |
| ADCY3 |
adenylate cyclase 3 |
Literature-origin
|
2(1/1) |
| KRAS |
Kirsten rat sarcoma viral oncogene homolog |
Protein mapped
|
0(0/0) |
| PRKACB |
protein kinase, cAMP-dependent, catalytic, beta |
Protein mapped
|
0(0/0) |
| GRM5 |
glutamate receptor, metabotropic 5 |
Protein mapped
|
0(0/0) |
| DRD2 |
dopamine receptor D2 |
Literature-origin; Protein mapped
|
5(3/2) |
| PRKACA |
protein kinase, cAMP-dependent, catalytic, alpha |
Protein mapped
|
0(0/0) |
| PRKCB |
protein kinase C, beta |
Literature-origin; Protein mapped
|
1(1/0) |
| GRM1 |
glutamate receptor, metabotropic 1 |
Literature-origin
|
2(2/0) |
| PRKCG |
protein kinase C, gamma |
SNP mapped
|
0(0/0) |
| HTR2C |
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled |
Literature-origin; SNP mapped
|
4(3/1) |
