MK4MDD

Gene Report

Basic Information
Approved Symbol HTR2C
Approved Name 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
Previous Symbol HTR1C
Previous Name "5-hydroxytryptamine (serotonin) receptor 2C"
Symbol Alias 5-HT2C, 5HTR2C
Location Xq23
Position chrX:114141979-114144624 (+)
External Links Entrez Gene: 3358
Ensembl: ENSG00000147246
UCSC: uc004epu.1
HGNC ID: 5295
No. of Studies (Positive/Negative) 4(3/1) Help
Type Literature-origin; SNP mapped

Positive relationships between HTR2C and MDD (count: 3)
Name in Literature Reference Research Type Statistical Result Relation Description Help
HTR2C Lerer B, 2001 Patients and nomal controls chi(2) = 7.34; df 1; P = 0.006 There was significant variation in the frequency of the HT2C...... There was significant variation in the frequency of the HT2CR ser23 allele among the 10 population groups included in the sample (from 24.6% in Greek control subjects to 9.2% in Scots, chi(2) = 20.9, df 9, P = 0.01). Logistic regression analysis demonstrated that over and above this inter-population variability, there was a significant excess of HT2CR ser23 allele carriers in patients compared to normal controls that was demonstrable for both the MDD (chi(2) = 7.34, df 1, P = 0.006) and BP (chi(2) = 5.45, df 1, P = 0.02) patients. More...
HTR2C Koks, 2006 patients and normal controls SNPs in CCKAR, DRD1, DRD2, and HTR2C genes showed nominally ...... SNPs in CCKAR, DRD1, DRD2, and HTR2C genes showed nominally significant associations with MDD. More...
5-HT-2C receptor (HTR2C) Vimaleswaran, 2010 nomal people Odds ratio (OR): 1.13 (95% CI: 1.01-1.22), P-value=0.02 The T allele of the -759C/T SNP in HTR2C showed borderline s...... The T allele of the -759C/T SNP in HTR2C showed borderline significant associations with and increased risk of lifetime major depressive disorder (MDD) (Odds ratio (OR): 1.13 (95% CI: 1.01-1.22), P=0.02). More...

Positive relationships between HTR2C and other components at different levels (count: 0) Help
Positive relationship network of HTR2C in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between HTR2C and MDD (count: 0)
Negative relationships between HTR2C and other components at different levels (count: 1) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


HTR2C related SNPs in MK4MDD (count: 1)
HTR2C related proteins in MK4MDD (count: 0)
HTR2C related GO terms (count: 26)
HTR2C related KEGG pathways (count: 3)
HTR2C related BioCarta pathways (count: 0)
HTR2C related Reactome pathways (count: 6)
HTR2C related interactors from protein-protein interaction data in HPRD (count: 8)