Gene Report

Basic Information

Approved Symbol	HTR2C
Approved Name	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
Previous Symbol	HTR1C
Previous Name	5-hydroxytryptamine (serotonin) receptor 2C
Symbol Alias	5-HT2C
Location	Xq23
Position	chrX:113818551-114144624 (+)
External Links	Entrez Gene: 3358 Ensembl: ENSG00000147246 UCSC: uc004epu.1 HGNC ID: 5295
No. of Studies (Positive/Negative)	4(3/1)
Type	Literature-origin; SNP mapped

Positive relationships between HTR2C and MDD (count: 3)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
HTR2C	Lerer B, 2001	Patients and nomal controls	chi(2) = 7.34; df 1; P = 0.006	There was significant variation in the frequency of the HT2C...... There was significant variation in the frequency of the HT2CR ser23 allele among the 10 population groups included in the sample (from 24.6% in Greek control subjects to 9.2% in Scots, chi(2) = 20.9, df 9, P = 0.01). Logistic regression analysis demonstrated that over and above this inter-population variability, there was a significant excess of HT2CR ser23 allele carriers in patients compared to normal controls that was demonstrable for both the MDD (chi(2) = 7.34, df 1, P = 0.006) and BP (chi(2) = 5.45, df 1, P = 0.02) patients. More...
HTR2C	Koks, 2006	patients and normal controls		SNPs in CCKAR, DRD1, DRD2, and HTR2C genes showed nominally ...... SNPs in CCKAR, DRD1, DRD2, and HTR2C genes showed nominally significant associations with MDD. More...
5-HT-2C receptor (HTR2C)	Vimaleswaran, 2010	nomal people	Odds ratio (OR): 1.13 (95% CI: 1.01-1.22), P-value=0.02	The T allele of the -759C/T SNP in HTR2C showed borderline s...... The T allele of the -759C/T SNP in HTR2C showed borderline significant associations with and increased risk of lifetime major depressive disorder (MDD) (Odds ratio (OR): 1.13 (95% CI: 1.01-1.22), P=0.02). More...

Positive relationships between HTR2C and other components at different levels (count: 0)

Positive relationship network of HTR2C in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between HTR2C and MDD (count: 0)

Negative relationships between HTR2C and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description
Name in Literature	Related Components
HTR2C		Suicide(suicide attempt)	symptoms	Serretti A, 2007	Patients and nomal controls		our study does not support the notion that HTR2C and HTR1A g...... our study does not support the notion that HTR2C and HTR1A gene variants are major contributors to suicide-, anger-, or aggression-related behaviors in our sample More...

HTR2C related SNPs in MK4MDD (count: 1)

#rs	Location	Annotation	No. of Studies (Positive/Negative)
rs6318	chrX:113965735(Forward)	missense_variant	1(1/0)

HTR2C related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
5-hydroxytryptamine receptor 2C	P28335	0(0/0)	Gene mapped

HTR2C related GO terms (count: 15)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0007268	synaptic transmission	biological process	TAS[9241279]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0007210	serotonin receptor signaling pathway	biological process	IMP[18703043]
GO:0006182	cGMP biosynthetic process	biological process	IDA[12970106]
GO:0071886	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	molecular function	IDA[19057895]
GO:0005886	plasma membrane	cellular component	IDA[12970106]; TAS
GO:0016021	integral to membrane	cellular component	IEA
GO:0051378	serotonin binding	molecular function	IDA[7582481]
GO:0006661	phosphatidylinositol biosynthetic process	biological process	IMP[19057895]
GO:0070371	ERK1 and ERK2 cascade	biological process	IMP[19057895]
GO:0004435	phosphatidylinositol phospholipase C activity	molecular function	IDA[12970106]
GO:0008144	drug binding	molecular function	IDA[15831837]
GO:0042493	response to drug	biological process	IDA[18703043]
GO:0004993	serotonin receptor activity	molecular function	IDA[7582481]
GO:0007631	feeding behavior	biological process	TAS[7700379]
GO:0051209	release of sequestered calcium ion into cytosol	biological process	IMP[18703043]

HTR2C related KEGG pathways (count: 3)

ID	Name	Brief Description	Full Description
Literature-origin KEGG pathway
hsa04020	calcium signaling_pathway	Calcium signaling pathway	Ca2+ that enters the cell from the outside is a principal so...... Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs). The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it. The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM). More...

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04540	gap junction	Gap junction	Gap junctions contain intercellular channels that allow dire...... Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation. More...
hsa04080	neuroactive ligand_receptor_interaction	Neuroactive ligand-receptor interaction

HTR2C related BioCarta pathways (count: 0)

HTR2C related Reactome pathways (count: 6)

ID	Name	Description
Gene mapped Reactome pathways
REACT_17064	serotonin receptors	Serotonin. Serotonin.
REACT_14828	class a1_rhodopsin_like_receptors	Rhodopsin-like receptors. They represent members which inclu...... Rhodopsin-like receptors. They represent members which include hormone, light and neurotransmitter receptors and encompass a wide range of functions including many autocrine, paracrine and endocrine processes. More...
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...
REACT_16983	amine ligand_binding_receptors	The class A (rhodopsin-like) GPCRs that bind to classical bi...... The class A (rhodopsin-like) GPCRs that bind to classical biogenic amine ligands are annotated here. The amines involved (acetylcholine, adrenaline, noradrenaline, dopamine, serotonin and histamine) can all act as neurotransmitters in humans. The so-called 'trace amines', used when referring to p-tyramine, beta-phenylethylamine, tryptamine and octopamine, can also bind to recently-discovered GPCRs. More...
REACT_18283	g alpha_q_signalling_events	The classic signalling route for G alpha (q) is activation o...... The classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides a path to calcium-regulated kinases and phosphatases, GEFs, MAP kinase cassettes and other proteins that mediate cellular responses ranging from granule secretion, integrin activation, and aggregation in platelets. Gq participates in many other signalling events including direct interaction with RhoGEFs that stimulate RhoA activity and inhibition of PI3K. Both in vitro and in vivo, the G-protein Gq seems to be the predominant mediator of the activation of platelets. More...
REACT_21340	gpcr ligand_binding	There are more than 800 G-protein coupled receptor. GPCRs ar...... There are more than 800 G-protein coupled receptor. GPCRs are receptors for a diverse range of ligands from large proteins to photons and have an equal diverstiy of ligand-binding mechanisms. Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. More...

HTR2C related interactors from protein-protein interaction data in HPRD (count: 8)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
HTR2C	CALM1	No	in vivo	18768750
HTR2C	DLG4	Yes	in vivo	12006486
HTR2C	HTR2C	Yes	in vitro	15518545
HTR2C	LIN7C	No	in vivo	12006486
HTR2C	APBA1	No	in vivo	12006486
HTR2C	MPDZ	No	in vitro;in vivo;yeast 2-hybrid	11150294 , 9537516
HTR2C	ARRB2	No	in vivo	18768750
HTR2C	GNAQ	No	in vivo	11916537

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Literature-origin KEGG pathway

Gene mapped KEGG pathways

Gene mapped Reactome pathways