Reactome Pathway Report
Basic Information
| ID |
|
| Name |
amine ligand_binding_receptors
|
| Description |
The class A (rhodopsin-like) GPCRs that bind to classical biogenic amine ligands are annotated here. The amines involved (acetylcholine, adrenaline, noradrenaline, dopamine, serotonin and histamine) can all act as neurotransmitters in humans. The so-called 'trace amines', used when referring to p-tyramine, beta-phenylethylamine, tryptamine and octopamine, can also bind to recently-discovered GPCRs.
|
REACT_16983 related genes in MK4MDD (count: 16)
| Approved Symbol |
Approved Name |
Type |
No. of Studies (Positive/Negative) |
| HTR1B |
5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled |
Literature-origin; Protein mapped
|
5(4/1) |
| HTR4 |
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled |
Literature-origin
|
1(1/0) |
| DRD1 |
dopamine receptor D1 |
Literature-origin; Protein mapped
|
2(2/0) |
| HRH1 |
histamine receptor H1 |
Protein mapped
|
0(0/0) |
| CHRM2 |
cholinergic receptor, muscarinic 2 |
Literature-origin; Protein mapped
|
2(1/1) |
| HTR1A |
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled |
Literature-origin; Protein mapped
|
15(11/4) |
| ADRA2A |
adrenoceptor alpha 2A |
Literature-origin; Protein mapped
|
2(2/0) |
| HTR5A |
5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled |
Literature-origin
|
2(0/2) |
| HTR2A |
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled |
Literature-origin; SNP mapped; Protein mapped
|
11(7/4) |
| ADRA2C |
adrenoceptor alpha 2C |
Protein mapped
|
0(0/0) |
| DRD2 |
dopamine receptor D2 |
Literature-origin; Protein mapped
|
5(3/2) |
| DRD4 |
dopamine receptor D4 |
Literature-origin
|
2(0/2) |
| HTR1D |
5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled |
Literature-origin
|
1(1/0) |
| DRD3 |
dopamine receptor D3 |
SNP mapped; Protein mapped
|
0(0/0) |
| HTR2C |
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled |
Literature-origin; SNP mapped
|
4(3/1) |
| ADRB2 |
adrenoceptor beta 2, surface |
Literature-origin
|
1(1/0) |
