Reactome Pathway Report

Basic Information
Name amine ligand_binding_receptors
Description The class A (rhodopsin-like) GPCRs that bind to classical biogenic amine ligands are annotated here. The amines involved (acetylcholine, adrenaline, noradrenaline, dopamine, serotonin and histamine) can all act as neurotransmitters in humans. The so-called 'trace amines', used when referring to p-tyramine, beta-phenylethylamine, tryptamine and octopamine, can also bind to recently-discovered GPCRs.

REACT_16983 related genes in MK4MDD (count: 16)
Approved Symbol Approved Name Type No. of Studies (Positive/Negative)
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled Literature-origin; Protein mapped 5(4/1)
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled Literature-origin 1(1/0)
DRD1 dopamine receptor D1 Literature-origin; Protein mapped 2(2/0)
HRH1 histamine receptor H1 Protein mapped 0(0/0)
CHRM2 cholinergic receptor, muscarinic 2 Literature-origin; Protein mapped 2(1/1)
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled Literature-origin; Protein mapped 15(11/4)
ADRA2A adrenoceptor alpha 2A Literature-origin; Protein mapped 2(2/0)
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled Literature-origin 2(0/2)
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Literature-origin; SNP mapped; Protein mapped 11(7/4)
ADRA2C adrenoceptor alpha 2C Protein mapped 0(0/0)
DRD2 dopamine receptor D2 Literature-origin; Protein mapped 5(3/2)
DRD4 dopamine receptor D4 Literature-origin 2(0/2)
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled Literature-origin 1(1/0)
DRD3 dopamine receptor D3 SNP mapped; Protein mapped 0(0/0)
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Literature-origin; SNP mapped 4(3/1)
ADRB2 adrenoceptor beta 2, surface Literature-origin 1(1/0)