MK4MDD

Gene Report

Basic Information
Approved Symbol HTR1B
Approved Name 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
Previous Name "5-hydroxytryptamine (serotonin) receptor 1B"
Symbol Alias S12, 5-HT1B, HTR1D2, 5-HT1DB
Location 6q13
Position chr6:78171948-78173120 (-)
External Links Entrez Gene: 3351
Ensembl: ENSG00000135312
UCSC: uc003pil.1
HGNC ID: 5287
No. of Studies (Positive/Negative) 5(4/1) Help
Type Literature-origin; Protein mapped

Positive relationships between HTR1B and MDD (count: 2)
Name in Literature Reference Research Type Statistical Result Relation Description Help
5-HT(1B) Huang, 2003 patients and normal controls P-value<0.05 Exploratory analyses indicated an association of the genotyp...... Exploratory analyses indicated an association of the genotype and allele frequencies of the h5-HTR(1B) G861C locus with a history of substance abuse disorder (chi(2) = 9.51, df = 2, p = 0.009; chi(2) = 7.31, df = 1, p = 0.007, respectively) and with a diagnosis of a major depressive episode (chi(2) = 6.83, df = 2, p = 0.033; chi(2) = 5.81, df = 1, p = 0.016, respectively). More...
HTR1B Belzeaux, 2010 patients and normal controls We also observed that variations in other mRNA expression we...... We also observed that variations in other mRNA expression were associated with treatment efficacy or clinical improvement (CREB1, HDAC5, HSPA2, HTR1B, HTR2A, and SLC6A4/5HTT). More...

Positive relationships between HTR1B and other components at different levels (count: 2) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of HTR1B in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between HTR1B and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description
5-HT1B Tsai SJ, 2004 Patients and nomal controls No significant difference was found in the A-161T genetic po...... No significant difference was found in the A-161T genetic polymorphism between MDD patients and controls. The genotype distribution between patients with and without suicide attempt, or between fluoxetine treatment responders and nonresponders were also similar. More...

Negative relationships between HTR1B and other components at different levels (count: 0) Help
HTR1B related SNPs in MK4MDD (count: 0)
HTR1B related proteins in MK4MDD (count: 1)
HTR1B related GO terms (count: 27)
HTR1B related KEGG pathways (count: 1)
HTR1B related BioCarta pathways (count: 0)
HTR1B related Reactome pathways (count: 6)
HTR1B related interactors from protein-protein interaction data in HPRD (count: 3)