Gene Report

Basic Information

Approved Symbol	HTR1B
Approved Name	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
Previous Name	5-hydroxytryptamine (serotonin) receptor 1B
Symbol Alias	S12, 5-HT1B, HTR1D2, 5-HT1DB
Location	6q13
Position	chr6:78171948-78173120 (-)
External Links	Entrez Gene: 3351 Ensembl: ENSG00000135312 UCSC: uc003pil.1 HGNC ID: 5287
No. of Studies (Positive/Negative)	5(4/1)
Type	Literature-origin; SNP mapped; Protein mapped

Positive relationships between HTR1B and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
5-HT(1B)	Huang, 2003	patients and normal controls	P-value<0.05	Exploratory analyses indicated an association of the genotyp...... Exploratory analyses indicated an association of the genotype and allele frequencies of the h5-HTR(1B) G861C locus with a history of substance abuse disorder (chi(2) = 9.51, df = 2, p = 0.009; chi(2) = 7.31, df = 1, p = 0.007, respectively) and with a diagnosis of a major depressive episode (chi(2) = 6.83, df = 2, p = 0.033; chi(2) = 5.81, df = 1, p = 0.016, respectively). More...
HTR1B	Belzeaux, 2010	patients and normal controls		We also observed that variations in other mRNA expression we...... We also observed that variations in other mRNA expression were associated with treatment efficacy or clinical improvement (CREB1, HDAC5, HSPA2, HTR1B, HTR2A, and SLC6A4/5HTT). More...

Positive relationships between HTR1B and other components at different levels (count: 2)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Relation Description
Name in Literature	Related Components
HTR1B		Suicide(suicide attempt)	symptoms	Wang, 2009	patients and normal controls	An allele association study revealed a significant relations...... An allele association study revealed a significant relationship between rs11568817 and suicidal ideation More...
5-HT(1B)		Feelings of hopelessness, worthlessness, and guilt(helplessness)	symptoms	McDevitt, 2011	animal model	The 5-HT(1B) autoreceptors originating in the caudal DRN reg...... The 5-HT(1B) autoreceptors originating in the caudal DRN regulate behavioral expression of helplessness and fear.Overexpression of 5-HT(1B) in the caudal DRN increased swimming in the forced swim test. More...

Positive relationship network of HTR1B in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between HTR1B and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
5-HT1B	Tsai SJ, 2004	Patients and nomal controls		No significant difference was found in the A-161T genetic po...... No significant difference was found in the A-161T genetic polymorphism between MDD patients and controls. The genotype distribution between patients with and without suicide attempt, or between fluoxetine treatment responders and nonresponders were also similar. More...

Negative relationships between HTR1B and other components at different levels (count: 0)

HTR1B related SNPs in MK4MDD (count: 1)

#rs	Location	Annotation	No. of Studies (Positive/Negative)
rs11568817	chr6:78173382(Forward)	5_prime_UTR_variant	1(1/0)

HTR1B related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
5-hydroxytryptamine receptor 1B	P28222	2(2/0)	Literature-origin

HTR1B related GO terms (count: 22)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0007268	synaptic transmission	biological process	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0051378	serotonin binding	molecular function	IEA
GO:0071502	cellular response to temperature stimulus	biological process	IEA
GO:0007186	G-protein coupled receptor signaling pathway	biological process	TAS[1315531]
GO:0008144	drug binding	molecular function	IEA
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	biological process	TAS[1559993]
GO:0014059	regulation of dopamine secretion	biological process	IEA
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	biological process	IEA
GO:0005887	integral to plasma membrane	cellular component	TAS[1559993]
GO:0046849	bone remodeling	biological process	IEA
GO:0042220	response to cocaine	biological process	IEA
GO:0005737	cytoplasm	cellular component	IEA
GO:0051967	negative regulation of synaptic transmission, glutamatergic	biological process	IEA
GO:0032229	negative regulation of synaptic transmission, GABAergic	biological process	IEA
GO:0005886	plasma membrane	cellular component	TAS
GO:0002031	G-protein coupled receptor internalization	biological process	IEA
GO:0051385	response to mineralocorticoid stimulus	biological process	IEA
GO:0042493	response to drug	biological process	IEA
GO:0004993	serotonin receptor activity	molecular function	IEA
GO:0045471	response to ethanol	biological process	IEA
GO:0042756	drinking behavior	biological process	IEA
GO:0030818	negative regulation of cAMP biosynthetic process	biological process	IDA[8882600]

HTR1B related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa04080	neuroactive ligand_receptor_interaction	Neuroactive ligand-receptor interaction

HTR1B related BioCarta pathways (count: 0)

HTR1B related Reactome pathways (count: 6)

ID	Name	Description
Gene mapped Reactome pathways
REACT_14828	class a1_rhodopsin_like_receptors	Rhodopsin-like receptors. They represent members which inclu...... Rhodopsin-like receptors. They represent members which include hormone, light and neurotransmitter receptors and encompass a wide range of functions including many autocrine, paracrine and endocrine processes. More...
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...
REACT_16983	amine ligand_binding_receptors	The class A (rhodopsin-like) GPCRs that bind to classical bi...... The class A (rhodopsin-like) GPCRs that bind to classical biogenic amine ligands are annotated here. The amines involved (acetylcholine, adrenaline, noradrenaline, dopamine, serotonin and histamine) can all act as neurotransmitters in humans. The so-called 'trace amines', used when referring to p-tyramine, beta-phenylethylamine, tryptamine and octopamine, can also bind to recently-discovered GPCRs. More...
REACT_17064	serotonin receptors	Serotonin. Serotonin.
REACT_19231	g alpha_i_signalling_events	The classical signalling mechanism for G alpha (i) is inhibi...... The classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased activity of cAMP-dependent protein kinases. More...
REACT_21340	gpcr ligand_binding	There are more than 800 G-protein coupled receptor. GPCRs ar...... There are more than 800 G-protein coupled receptor. GPCRs are receptors for a diverse range of ligands from large proteins to photons and have an equal diverstiy of ligand-binding mechanisms. Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. More...

HTR1B related interactors from protein-protein interaction data in HPRD (count: 3)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
HTR1B	HTR1D	Yes	in vivo	11854302
HTR1B	HTR1B	Yes	in vitro	11854302
HTR1B	HTR1A	Yes	in vitro;in vivo	11854302

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways