Gene Report

Basic Information

Approved Symbol	HTR1D
Approved Name	5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
Previous Symbol	HTRL
Previous Name	5-hydroxytryptamine (serotonin) receptor 1D
Symbol Alias	RDC4, HT1DA, 5-HT1D
Location	1p36.3-p34.3
Position	chr1:23518388-23521222 (-)
External Links	Entrez Gene: 3352 Ensembl: ENSG00000179546 UCSC: uc001bgn.3 HGNC ID: 5289
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between HTR1D and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
5-HT1D receptor	Goswami, 2010	patients and normal controls		We found that mRNA concentrations of the 5-HT1D receptor and...... We found that mRNA concentrations of the 5-HT1D receptor and the transcription factors, NUDR and REST, were significantly increased in DR-captured neurons of female MDD subjects compared to female control subjects More...

Positive relationships between HTR1D and other components at different levels (count: 0)

Positive relationship network of HTR1D in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between HTR1D and MDD (count: 0)

Negative relationships between HTR1D and other components at different levels (count: 0)

HTR1D related SNPs in MK4MDD (count: 0)

HTR1D related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
5-hydroxytryptamine receptor 1D	P28221	0(0/0)	Gene mapped

HTR1D related GO terms (count: 8)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0007268	synaptic transmission	biological process	TAS[1565658]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0004993	serotonin receptor activity	molecular function	IEA
GO:0009636	response to toxin	biological process	IEA
GO:0005887	integral to plasma membrane	cellular component	TAS[1652050]
GO:0005886	plasma membrane	cellular component	TAS
GO:0014827	intestine smooth muscle contraction	biological process	IMP[9186750]
GO:0051378	serotonin binding	molecular function	IEA
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	biological process	TAS[1565658]

HTR1D related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa04080	neuroactive ligand_receptor_interaction	Neuroactive ligand-receptor interaction

HTR1D related BioCarta pathways (count: 0)

HTR1D related Reactome pathways (count: 6)

ID	Name	Description
Gene mapped Reactome pathways
REACT_19231	g alpha_i_signalling_events	The classical signalling mechanism for G alpha (i) is inhibi...... The classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased activity of cAMP-dependent protein kinases. More...
REACT_14828	class a1_rhodopsin_like_receptors	Rhodopsin-like receptors. They represent members which inclu...... Rhodopsin-like receptors. They represent members which include hormone, light and neurotransmitter receptors and encompass a wide range of functions including many autocrine, paracrine and endocrine processes. More...
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...
REACT_21340	gpcr ligand_binding	There are more than 800 G-protein coupled receptor. GPCRs ar...... There are more than 800 G-protein coupled receptor. GPCRs are receptors for a diverse range of ligands from large proteins to photons and have an equal diverstiy of ligand-binding mechanisms. Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. More...
REACT_17064	serotonin receptors	Serotonin. Serotonin.
REACT_16983	amine ligand_binding_receptors	The class A (rhodopsin-like) GPCRs that bind to classical bi...... The class A (rhodopsin-like) GPCRs that bind to classical biogenic amine ligands are annotated here. The amines involved (acetylcholine, adrenaline, noradrenaline, dopamine, serotonin and histamine) can all act as neurotransmitters in humans. The so-called 'trace amines', used when referring to p-tyramine, beta-phenylethylamine, tryptamine and octopamine, can also bind to recently-discovered GPCRs. More...

HTR1D related interactors from protein-protein interaction data in HPRD (count: 4)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
HTR1D	S1PR1	No	in vivo	11854302
HTR1D	HTR1A	Yes	in vitro;in vivo	11854302
HTR1D	HTR1B	Yes	in vivo	11854302
HTR1D	HTR1D	Yes	in vivo	11854302

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways