MK4MDD

Gene Report

Basic Information
Approved Symbol HTR1A
Approved Name 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
Previous Symbol ADRB2RL1, ADRBRL1
Previous Name "5-hydroxytryptamine (serotonin) receptor 1A"
Symbol Alias 5-HT1A
Location 5q11.2-q13
Position chr5:63257547-63258119 (-)
External Links Entrez Gene: 3350
Ensembl: ENSG00000178394
UCSC: uc011cqt.3
HGNC ID: 5286
No. of Studies (Positive/Negative) 15(11/4) Help
Type Literature-origin; Protein mapped

Positive relationships between HTR1A and MDD (count: 6)
Name in Literature Reference Research Type Statistical Result Relation Description Help
5-HT1A Lemonde, 2003 patients and normal controls genotype: P-value = 0.0017 , allele: P-value= 0.0006 In depressed patients, the homozygous G(-1019) allele was en...... In depressed patients, the homozygous G(-1019) allele was enriched twofold versus controls (p = 0.0017 and 0.0006 for G/G genotype and G allele distribution, respectively), and in completed suicide cases the G(-1019) allele was enriched fourfold (p = 0.002 and 0.00008 for G/G genotype and G allele distribution, respectively). More...
5-HT(1A) Lopez-Figueroa, 2004 patients and normal controls In the DLPFC(dorsolateral prefrontal cortex), there is a sig...... In the DLPFC(dorsolateral prefrontal cortex), there is a significant decrease in 5-HT(1A) mRNA of subjects with MDD More...
HTR1A Neff, 2009 patients and normal controls Linkage analysis on Utah pedigrees with strong family histor...... Linkage analysis on Utah pedigrees with strong family histories of major depression including only cases with the HTR1A -1019G allele revealed a linkage peak on chromosome 10 (maximum HLOD=4.4) More...
5-HTR1A Wu, 2008 patients and normal controls Chi(2) = 10.913, df = 2, P-value = 0.004 There was a statistically significant difference between MDD...... There was a statistically significant difference between MDD patients and controls in both the genotype distribution (Chi(2) = 10.913, df = 2, P = 0.004) and the allele frequency (Chi(2) = 10.379, df = 1, P = 0.001) More...
5-HT(1A) receptor Haenisch, 2009 patients and normal controls The sample comprised 426 patients suffering from unipolar MD...... The sample comprised 426 patients suffering from unipolar MD as well as 643 healthy control subjects for the variants of the 5-HT(1A) receptor and the NET. Both SNPs were shown to be associated with MD. In conclusio More...
HTR1A Molina E, 2011 Patients and nomal controls OR = 1.67; 95%; CI = 1.14-2.44; P = 0.008 Genetic variability at HTR1A was significantly associated wi...... Genetic variability at HTR1A was significantly associated with MD [odds ratio (OR) = 1.67; 95% confidence interval (CI) = 1.14-2.44; P = 0.008] More...

Positive relationships between HTR1A and other components at different levels (count: 7) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of HTR1A in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between HTR1A and MDD (count: 3)
Name in Literature Reference Research Type Statistical Result Relation Description
HTR1A Hettema JM, 2008 Patients and nomal controls four SNPs spanning the HTR1A locus, including the C(-1019)G ...... four SNPs spanning the HTR1A locus, including the C(-1019)G functional promoter polymorphism (rs6295), were screened in stage 1, the positive results of which were tested for replication in stage 2. While one marker met threshold significance criteria in stage 1, this association was not replicated in stage 2. More...
5HTR1A Crisafulli C, 2013 patients and normal controls No association with mood disorders and clinical outcomes was...... No association with mood disorders and clinical outcomes was observed More...
HTR1A Lan, 2014 Patients and nomal controls p = 0.125 The MDD group met carriers had 0 subjects with AA and 16 sub...... The MDD group met carriers had 0 subjects with AA and 16 subjectswith AG and 34 subjects with GG allele. The HV group had 4 subjects with AA, 19 subjectswith AG and 27 with GG allele. The allelic distribution (number of G alleles) showed a trend of a difference between MDD and HV groups in the vall66met allele (p= 0.087), but no difference in the 5-HT1A receptor C-1019G allele (p = 0.125). More...

Negative relationships between HTR1A and other components at different levels (count: 1) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


HTR1A related SNPs in MK4MDD (count: 0)
HTR1A related proteins in MK4MDD (count: 1)
HTR1A related GO terms (count: 17)
HTR1A related KEGG pathways (count: 1)
HTR1A related BioCarta pathways (count: 0)
HTR1A related Reactome pathways (count: 6)
HTR1A related interactors from protein-protein interaction data in HPRD (count: 8)