Gene Report

Basic Information

Approved Symbol	HTR1A
Approved Name	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
Previous Symbol	ADRB2RL1, ADRBRL1
Previous Name	5-hydroxytryptamine (serotonin) receptor 1A
Symbol Alias	5-HT1A
Location	5q11.2-q13
Position	chr5:63255875-63258119 (-)
External Links	Entrez Gene: 3350 Ensembl: ENSG00000178394 UCSC: uc011cqt.2 HGNC ID: 5286
No. of Studies (Positive/Negative)	13(11/2)
Type	Literature-origin; SNP mapped; Protein mapped

Positive relationships between HTR1A and MDD (count: 6)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
5-HT1A	Lemonde, 2003	patients and normal controls	genotype: P-value = 0.0017 , allele: P-value= 0.0006	In depressed patients, the homozygous G(-1019) allele was en...... In depressed patients, the homozygous G(-1019) allele was enriched twofold versus controls (p = 0.0017 and 0.0006 for G/G genotype and G allele distribution, respectively), and in completed suicide cases the G(-1019) allele was enriched fourfold (p = 0.002 and 0.00008 for G/G genotype and G allele distribution, respectively). More...
5-HT(1A)	Lopez-Figueroa, 2004	patients and normal controls		In the DLPFC(dorsolateral prefrontal cortex), there is a sig...... In the DLPFC(dorsolateral prefrontal cortex), there is a significant decrease in 5-HT(1A) mRNA of subjects with MDD More...
HTR1A	Neff, 2009	patients and normal controls		Linkage analysis on Utah pedigrees with strong family histor...... Linkage analysis on Utah pedigrees with strong family histories of major depression including only cases with the HTR1A -1019G allele revealed a linkage peak on chromosome 10 (maximum HLOD=4.4) More...
5-HTR1A	Wu, 2008	patients and normal controls	Chi(2) = 10.913, df = 2, P-value = 0.004	There was a statistically significant difference between MDD...... There was a statistically significant difference between MDD patients and controls in both the genotype distribution (Chi(2) = 10.913, df = 2, P = 0.004) and the allele frequency (Chi(2) = 10.379, df = 1, P = 0.001) More...
5-HT(1A) receptor	Haenisch, 2009	patients and normal controls		The sample comprised 426 patients suffering from unipolar MD...... The sample comprised 426 patients suffering from unipolar MD as well as 643 healthy control subjects for the variants of the 5-HT(1A) receptor and the NET. Both SNPs were shown to be associated with MD. In conclusio More...
HTR1A	Molina E, 2011	Patients and nomal controls	OR = 1.67; 95%; CI = 1.14-2.44; P = 0.008	Genetic variability at HTR1A was significantly associated wi...... Genetic variability at HTR1A was significantly associated with MD [odds ratio (OR) = 1.67; 95% confidence interval (CI) = 1.14-2.44; P = 0.008] More...

Positive relationships between HTR1A and other components at different levels (count: 7)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description
Name in Literature	Related Components
Htr1a		SLC17A7(vesicular glutamate transporter 1 (VGLUT1))	gene	Tordera RM, 2011	animal model		gene was regulated in frontal cortex of VGLUT1(+/-) mice gene was regulated in frontal cortex of VGLUT1(+/-) mice
5-HT1A		5-hydroxytryptamine receptor 1A(serotonin 1A (5-HT1A))	protein	Parsey, 2006	patients and normal controls		Despite equivalent treatment, nonremitters have higher pretr...... Despite equivalent treatment, nonremitters have higher pretreatment cortical BP and the GG genotype is over-represented compared with remitters. Higher 5-HT1A BP, perhaps due to greater gene expression, may predict antidepressant medication nonremission. More...
serotonin 1A (5-HT1A) receptor gene		P200(P2)	neurobiological system	Chen, 2004	patients only	P-value<0.05	Patients with the C/C genotype had a significantly shorter P...... Patients with the C/C genotype had a significantly shorter P2 latency when compared with C/G or G/G genotype patients (p = 0.049), the difference in P2 latency was significant among the 5-HT1A genotype groups in male patients (p = 0.031) but not in female patients (p = 0.398). More...
5-HT(1A)		Hippocampus(hippocampus)	brain morphology and function	Lopez-Figueroa, 2004	patients and normal controls		Subjects with MDD have a significant decrease in 5-HT(1A) mR...... Subjects with MDD have a significant decrease in 5-HT(1A) mRNA in the hippocampus More...
5-HT(1A)		Amygdala(amygdala)	brain morphology and function	Dannlowski, 2007	patients and normal controls		Risk allele carriers for either gene showed significantly in...... Risk allele carriers for either gene showed significantly increased bilateral amygdala activation in response to emotional stimuli, implicating an additive effect of both genotypes. More...
5-HT1A		Suicide(suicide attempt)	symptoms	Lemonde, 2003	patients and normal controls	genotype: P-value = 0.002 , allele: P-value= 0.00008	In depressed patients, the homozygous G(-1019) allele was en...... In depressed patients, the homozygous G(-1019) allele was enriched twofold versus controls (p = 0.0017 and 0.0006 for G/G genotype and G allele distribution, respectively), and in completed suicide cases the G(-1019) allele was enriched fourfold (p = 0.002 and 0.00008 for G/G genotype and G allele distribution, respectively). More...
5-HT1A		Social defeat(chronic social defeat (CSD))	environment	Kieran, 2010	animal model		5-HT1A mRNA levels were significantly downregulated in the p...... 5-HT1A mRNA levels were significantly downregulated in the prefrontal cortex (PFC) in defeated animals More...

Positive relationship network of HTR1A in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between HTR1A and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
HTR1A	Hettema JM, 2008	Patients and nomal controls		four SNPs spanning the HTR1A locus, including the C(-1019)G ...... four SNPs spanning the HTR1A locus, including the C(-1019)G functional promoter polymorphism (rs6295), were screened in stage 1, the positive results of which were tested for replication in stage 2. While one marker met threshold significance criteria in stage 1, this association was not replicated in stage 2. More...

Negative relationships between HTR1A and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description
Name in Literature	Related Components
HTR1A		Suicide(suicide attempt)	symptoms	Serretti A, 2007	Patients and nomal controls		our study does not support the notion that HTR2C and HTR1A g...... our study does not support the notion that HTR2C and HTR1A gene variants are major contributors to suicide-, anger-, or aggression-related behaviors in our sample More...

HTR1A related SNPs in MK4MDD (count: 1)

#rs	Location	Annotation	No. of Studies (Positive/Negative)
rs878567	chr5:63255991(Forward)	downstream_gene_variant; intron_variant; nc_transcript_variant	1(1/0)

HTR1A related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
5-hydroxytryptamine receptor 1A	P08908	14(14/0)	Literature-origin

HTR1A related GO terms (count: 7)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0007186	G-protein coupled receptor signaling pathway	biological process	TAS[1330092]
GO:0008284	positive regulation of cell proliferation	biological process	TAS[1330092]
GO:0007610	behavior	biological process	TAS[9736659]
GO:0007210	serotonin receptor signaling pathway	biological process	TAS[9736659]
GO:0005886	plasma membrane	cellular component	TAS
GO:0004993	serotonin receptor activity	molecular function	IEA
GO:0005887	integral to plasma membrane	cellular component	TAS[3138543]

HTR1A related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa04080	neuroactive ligand_receptor_interaction	Neuroactive ligand-receptor interaction

HTR1A related BioCarta pathways (count: 0)

HTR1A related Reactome pathways (count: 6)

ID	Name	Description
Gene mapped Reactome pathways
REACT_14828	class a1_rhodopsin_like_receptors	Rhodopsin-like receptors. They represent members which inclu...... Rhodopsin-like receptors. They represent members which include hormone, light and neurotransmitter receptors and encompass a wide range of functions including many autocrine, paracrine and endocrine processes. More...
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...
REACT_17064	serotonin receptors	Serotonin. Serotonin.
REACT_19231	g alpha_i_signalling_events	The classical signalling mechanism for G alpha (i) is inhibi...... The classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased activity of cAMP-dependent protein kinases. More...
REACT_21340	gpcr ligand_binding	There are more than 800 G-protein coupled receptor. GPCRs ar...... There are more than 800 G-protein coupled receptor. GPCRs are receptors for a diverse range of ligands from large proteins to photons and have an equal diverstiy of ligand-binding mechanisms. Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. More...
REACT_16983	amine ligand_binding_receptors	The class A (rhodopsin-like) GPCRs that bind to classical bi...... The class A (rhodopsin-like) GPCRs that bind to classical biogenic amine ligands are annotated here. The amines involved (acetylcholine, adrenaline, noradrenaline, dopamine, serotonin and histamine) can all act as neurotransmitters in humans. The so-called 'trace amines', used when referring to p-tyramine, beta-phenylethylamine, tryptamine and octopamine, can also bind to recently-discovered GPCRs. More...

HTR1A related interactors from protein-protein interaction data in HPRD (count: 8)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
HTR1A	S1PR3	No	in vitro;in vivo	11854302
HTR1A	S1PR1	No	in vitro;in vivo	11854302
HTR1A	GABBR2	Yes	in vivo	11854302
HTR1A	HTR1B	Yes	in vitro;in vivo	11854302
HTR1A	HTR1A	Yes	in vivo	11854302
HTR1A	GPR26	No	in vitro;in vivo	11854302
HTR1A	HTR1D	Yes	in vitro;in vivo	11854302
HTR1A	GNAI3	No	in vitro;in vivo	8218170

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways