Study Report
Reference
| Citation | Lopez-Figueroa, 2004 PubMed |
| Full Info | Lopez-Figueroa, A.L., Norton, C.S., Lopez-Figueroa, M.O., Armellini-Dodel, D., Burke, S., Akil, H., Lopez, J.F. and Watson, S.J. (2004) Serotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophrenia. Biol Psychiatry, 55, 225-233.
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Study
| Hypothesis or Background |
Alterations of serotonin neurotransmission are implicated in both mood disorders and schizophrenia. Specific serotonin-receptor-based abnormalities in these psychiatric illnesses have been intensively studied; however, it has been difficult to draw any conclusions because of a lack of consensus. These inconsistencies have most likely arisen from the unavailability of selective ligands.
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| Sample Information | subjects with a history of major depression disorder (MDD), bipolar disorder (BPD), schizophrenia, and a normal comparison group (15 subjects per group) |
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| Method Detail | Our study used in situ hybridization to quantify 5-HT(1A), 5-HT(1B), and 5-HT(2A) mRNA levels in the hippocampus (HC) and 5-HT(1A) and 5-HT(2A) mRNA levels in the dorsolateral prefrontal cortex (DLPFC) of subjects with a history of major depression disorder (MDD), bipolar disorder (BPD), schizophrenia, and a normal comparison group (15 subjects per group). |
| Method Keywords | in situ hybridization |
| Result | In the DLPFC, there is a significant decrease in 5-HT(1A) mRNA of subjects with MDD and in 5-HT(2A) mRNA of subjects with BPD. Subjects with MDD have a significant decrease in 5-HT(1A) mRNA in the HC; subjects with BPD and schizophrenia had increased 5-HT(1B) mRNA levels and a significant decrease in 5-HT(2A) mRNA levels in the hippocampal formation. |
| Conclusions | Alterations in 5-HT(1A,) 5-HT(1B), and 5-HT(2A) mRNA levels in the brains of subjects with both mood disorders and schizophrenia add further support for hypothesis of dysregulation of the serotonergic system in these psychiatric disorders. |
Relationships reported by
Lopez-Figueroa, 2004
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
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MDD
|
syndrome |
HTR1A (5-HT(1A)) |
gene |
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In the DLPFC(dorsolateral prefrontal cortex), there is a significant decrease in 5-HT(1A) mRNA of subjects with MDD |
Positive
|
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Hippocampus (hippocampus)
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brain morphology and function |
HTR1A (5-HT(1A)) |
gene |
|
Subjects with MDD have a significant decrease in 5-HT(1A) mRNA in the hippocampus |
Positive
|
