Reactome Pathway Report

Basic Information

ID
Name	g alpha_i_signalling_events
Description	The classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased activity of cAMP-dependent protein kinases.

REACT_19231 related genes in MK4MDD (count: 40)

Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
ADRA2A	adrenoceptor alpha 2A	Literature-origin; Protein mapped	2(2/0)
GAL	galanin/GMAP prepropeptide	Literature-origin; SNP mapped	2(1/1)
HTR1D	5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled	Literature-origin	1(1/0)
GNAI3	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	SNP mapped	0(0/0)
AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Protein mapped	0(0/0)
HTR5A	5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled	Literature-origin	1(0/1)
SSTR5	somatostatin receptor 5	Literature-origin	1(1/0)
GNB3	guanine nucleotide binding protein (G protein), beta polypeptide 3	Literature-origin; SNP mapped	2(2/0)
OPRM1	opioid receptor, mu 1	Literature-origin; Protein mapped	1(1/0)
LPAR2	lysophosphatidic acid receptor 2	SNP mapped	0(0/0)
C3	complement component 3	Protein mapped	0(0/0)
CHRM2	cholinergic receptor, muscarinic 2	Literature-origin; SNP mapped; Protein mapped	2(1/1)
LPAR1	lysophosphatidic acid receptor 1	Literature-origin	1(1/0)
ADCY7	adenylate cyclase 7	Literature-origin; SNP mapped	2(2/0)
ADCY8	adenylate cyclase 8 (brain)	Literature-origin	2(2/0)
ADCY3	adenylate cyclase 3	Literature-origin; SNP mapped	1(0/1)
DRD4	dopamine receptor D4	Literature-origin	2(0/2)
IL8	interleukin 8	Literature-origin	1(1/0)
HTR1B	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled	Literature-origin; SNP mapped; Protein mapped	5(4/1)
GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1	Protein mapped	0(0/0)
PENK	proenkephalin	Literature-origin	1(1/0)
NPY	neuropeptide Y	Literature-origin; SNP mapped; Protein mapped	6(5/1)
CNR1	cannabinoid receptor 1 (brain)	Literature-origin; SNP mapped; Protein mapped	3(3/0)
HTR1A	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	Literature-origin; SNP mapped; Protein mapped	13(11/2)
GABBR2	gamma-aminobutyric acid (GABA) B receptor, 2	Literature-origin; Protein mapped	1(1/0)
BDKRB2	bradykinin receptor B2	SNP mapped	0(0/0)
POMC	proopiomelanocortin	Protein mapped	0(0/0)
ADRA2C	adrenoceptor alpha 2C	Protein mapped	0(0/0)
GNG3	guanine nucleotide binding protein (G protein), gamma 3	Literature-origin	1(1/0)
CXCR1	chemokine (C-X-C motif) receptor 1	Protein mapped	0(0/0)
GABBR1	gamma-aminobutyric acid (GABA) B receptor, 1	Literature-origin; Protein mapped	1(1/0)
BDKRB1	bradykinin receptor B1	Protein mapped	0(0/0)
P2RY12	purinergic receptor P2Y, G-protein coupled, 12	Literature-origin	1(1/0)
GALR2	galanin receptor 2	Literature-origin	1(1/0)
PDYN	prodynorphin	SNP mapped; Protein mapped	0(0/0)
SST	somatostatin	Literature-origin; Protein mapped	2(2/0)
DRD2	dopamine receptor D2	Literature-origin; Protein mapped	4(3/1)
DRD3	dopamine receptor D3	SNP mapped; Protein mapped	0(0/0)
CNR2	cannabinoid receptor 2 (macrophage)	Literature-origin	1(1/0)
ADCY9	adenylate cyclase 9	SNP mapped	0(0/0)