Reactome Pathway Report

Basic Information
Name g alpha_i_signalling_events
Description The classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased activity of cAMP-dependent protein kinases.

REACT_19231 related genes in MK4MDD (count: 43)
Approved Symbol Approved Name Type No. of Studies (Positive/Negative)
PENK proenkephalin Literature-origin 1(1/0)
LPAR1 lysophosphatidic acid receptor 1 Literature-origin 2(2/0)
P2RY12 purinergic receptor P2Y, G-protein coupled, 12 Literature-origin 1(1/0)
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 Protein mapped 0(0/0)
CHRM2 cholinergic receptor, muscarinic 2 Literature-origin; Protein mapped 2(1/1)
BDKRB1 bradykinin receptor B1 Protein mapped 0(0/0)
IL8 interleukin 8 Literature-origin; Protein mapped 2(2/0)
ADRA2A adrenoceptor alpha 2A Literature-origin; Protein mapped 2(2/0)
S1PR1 sphingosine-1-phosphate receptor 1 Literature-origin 1(1/0)
CNR2 cannabinoid receptor 2 (macrophage) Literature-origin 1(1/0)
PDYN prodynorphin Protein mapped 0(0/0)
ADRA2C adrenoceptor alpha 2C Protein mapped 0(0/0)
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 Literature-origin; SNP mapped 2(2/0)
OPRM1 opioid receptor, mu 1 Literature-origin; SNP mapped; Protein mapped 2(1/1)
DRD4 dopamine receptor D4 Literature-origin 2(0/2)
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 Literature-origin; Protein mapped 1(1/0)
BDKRB2 bradykinin receptor B2 SNP mapped 0(0/0)
DRD3 dopamine receptor D3 SNP mapped; Protein mapped 0(0/0)
CXCL2 chemokine (C-X-C motif) ligand 2 Literature-origin 1(1/0)
SSTR5 somatostatin receptor 5 Literature-origin 1(1/0)
POMC proopiomelanocortin Protein mapped 0(0/0)
SST somatostatin Literature-origin; Protein mapped 3(3/0)
NPY1R neuropeptide Y receptor Y1 Literature-origin 1(1/0)
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled Literature-origin; Protein mapped 5(4/1)
CNR1 cannabinoid receptor 1 (brain) Literature-origin; SNP mapped; Protein mapped 4(3/1)
ADCY8 adenylate cyclase 8 (brain) Literature-origin 2(2/0)
C3 complement component 3 Protein mapped 0(0/0)
ADCY7 adenylate cyclase 7 Literature-origin 2(2/0)
CCL20 chemokine (C-C motif) ligand 20 Literature-origin 1(1/0)
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 Literature-origin 1(1/0)
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled Literature-origin; Protein mapped 15(11/4)
CXCL3 chemokine (C-X-C motif) ligand 3 Literature-origin 1(1/0)
ADCY3 adenylate cyclase 3 Literature-origin 2(1/1)
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled Literature-origin 2(0/2)
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 Literature-origin; Protein mapped 1(1/0)
NPY neuropeptide Y Literature-origin; SNP mapped; Protein mapped 7(6/1)
DRD2 dopamine receptor D2 Literature-origin; Protein mapped 5(3/2)
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled Literature-origin 1(1/0)
GAL galanin/GMAP prepropeptide Literature-origin 2(1/1)
GNG3 guanine nucleotide binding protein (G protein), gamma 3 Literature-origin 1(1/0)
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Protein mapped 0(0/0)
GALR2 galanin receptor 2 Literature-origin 1(1/0)
CCR6 chemokine (C-C motif) receptor 6 Literature-origin 1(1/0)