Gene Report

Basic Information

Approved Symbol	GALR2
Approved Name	galanin receptor 2
Symbol Alias	GALNR2
Location	17q25.3
Position	chr17:74073513-74073573 (+)
External Links	Entrez Gene: 8811 Ensembl: ENSG00000182687 UCSC: uc002jqm.1 HGNC ID: 4133
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between GALR2 and MDD (count: 0)

Positive relationships between GALR2 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
galanin receptor 2		Depression-like behaviors from animal model(depressive-like behavior)	cognition and behavior	Wardi-Le Maitre, 2011	animal model		Three age groups of the transgenic mice (overexpressing a ga...... Three age groups of the transgenic mice (overexpressing a galanin receptor 2 (GalR2)-enhanced, green fluorescent protein (EGFP)-construct under the platelet-derived growth factor-B promoter) demonstrated decreased levels of immobility in the forced swim test, indicative of antidepressive-like behavior and/or increased stress resistance. More...

Positive relationship network of GALR2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between GALR2 and MDD (count: 0)

Negative relationships between GALR2 and other components at different levels (count: 0)

GALR2 related SNPs in MK4MDD (count: 0)

GALR2 related proteins in MK4MDD (count: 0)

GALR2 related GO terms (count: 26)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0007268	synaptic transmission	biological process	TAS[9832121]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0007218	neuropeptide signaling pathway	biological process	IDA[24517231]; IEA; TAS[9480833]
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	biological process	IEA
GO:0007631	feeding behavior	biological process	TAS[9480833]
GO:0005829	cytosol	cellular component	IEA; TAS[9685625]
GO:0042923	neuropeptide binding	molecular function	IEA
GO:0046488	phosphatidylinositol metabolic process	biological process	IEA
GO:0007586	digestion	biological process	TAS[9832121]
GO:0007166	cell surface receptor signaling pathway	biological process	TAS[9480833]
GO:0005887	integral component of plasma membrane	cellular component	IBA
GO:0016021	integral component of membrane	cellular component	TAS[9480833]
GO:0007611	learning or memory	biological process	TAS[9480833]
GO:0007194	negative regulation of adenylate cyclase activity	biological process	IEA
GO:0043647	inositol phosphate metabolic process	biological process	IEA
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	biological process	IBA
GO:1902608	positive regulation of large conductance calcium-activated potassium channel activity	biological process	IMP[24602615]
GO:0007204	positive regulation of cytosolic calcium ion concentration	biological process	IEA
GO:0007275	multicellular organism development	biological process	TAS[9480833]
GO:0005515	protein binding	molecular function	IPI[23597562\|25691535]
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	biological process	TAS[9685625]
GO:0006936	muscle contraction	biological process	TAS[9480833]
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[24517231]
GO:0017046	peptide hormone binding	molecular function	IDA[24517231]
GO:0005886	plasma membrane	cellular component	TAS
GO:0031175	neuron projection development	biological process	IEA
GO:0004966	galanin receptor activity	molecular function	IDA[24517231]

GALR2 related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa04080	neuroactive ligand_receptor_interaction	Neuroactive ligand-receptor interaction

GALR2 related BioCarta pathways (count: 0)

GALR2 related Reactome pathways (count: 5)

ID	Name	Description
Gene mapped Reactome pathways
REACT_19231	g alpha_i_signalling_events	The classical signalling mechanism for G alpha (i) is inhibi...... The classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased activity of cAMP-dependent protein kinases. More...
REACT_14819	peptide ligand_binding_receptors	These receptors, a subset of the Class A/1 (Rhodopsin-like) ...... These receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins. More...
REACT_21340	gpcr ligand_binding	There are more than 800 G-protein coupled receptor. GPCRs ar...... There are more than 800 G-protein coupled receptor. GPCRs are receptors for a diverse range of ligands from large proteins to photons and have an equal diverstiy of ligand-binding mechanisms. Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. More...
REACT_14828	class a1_rhodopsin_like_receptors	Rhodopsin-like receptors. They represent members which inclu...... Rhodopsin-like receptors. They represent members which include hormone, light and neurotransmitter receptors and encompass a wide range of functions including many autocrine, paracrine and endocrine processes. More...
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...

GALR2 related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
GALR2	GNAQ	No	in vivo	9685625
GALR2	GAL	Yes	in vivo	9685625

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways