MK4MDD

Gene Report

Basic Information
Approved Symbol NPY
Approved Name neuropeptide Y
Symbol Alias PYY4
Name Alias "prepro-neuropeptide Y"
Location 7p15.3
Position chr7:24331307-24331484 (+)
External Links Entrez Gene: 4852
Ensembl: ENSG00000122585
UCSC: uc003sww.2
HGNC ID: 7955
No. of Studies (Positive/Negative) 7(6/1) Help
Type Literature-origin; SNP mapped; Protein mapped

Positive relationships between NPY and MDD (count: 6)
Name in Literature Reference Research Type Statistical Result Relation Description Help
NPY Bosker, 2010 patients and normal controls P-value = 0.034; OR C allele = 0.73, 95% CI 0.55-0.97 associated with MDD (rs16139; P = 0.034; OR C allele = 0.73,...... associated with MDD (rs16139; P = 0.034; OR C allele = 0.73, 95% CI 0.55-0.97) More...
NPY Heilig M, 2004 Patients and nomal controls We then explored whether this finding might be related to a ...... We then explored whether this finding might be related to a recently described T1128C coding polymorphism which results in a Leu7-> Pro7 substitution of the signal peptide, and a previously not described T -399C polymorphism in the promoter region of the preproNPY gene. Preliminary evidence was found for an association of both markers with a diagnosis of depression, indicating the possibility of an underlying haplotype influencing the vulnerability for developing depressive illness More...
NPY Sjoholm LK, 2009 Patients and nomal controls OR=2.7; P=0.0004 Pro7 alle of NPY was rarer in depression cases than in healt...... Pro7 alle of NPY was rarer in depression cases than in healthy individuals More...
neuropeptide Y (NPY) Mickey, 2011 patients and normal controls P-value=0.04 Low-expression NPY genotypes were overrepresented in subject...... Low-expression NPY genotypes were overrepresented in subjects with MDD after controlling for age and sex (P = .004). More...
NPY Guilloux JP, 2012 patients and normal controls genes significantly affected in female MDD subjects genes significantly affected in female MDD subjects
NPY Tomita H, 2013 patients and normal controls GPLS genes significantly dysregulated in anterior cingulate ...... GPLS genes significantly dysregulated in anterior cingulate cortex by microarray More...

Positive relationships between NPY and other components at different levels (count: 2) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of NPY in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between NPY and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description
NPY Lindberg C, 2006 Patients and nomal controls We detected the polymorphism -399 C > T at a frequency of 48...... We detected the polymorphism -399 C > T at a frequency of 48% in controls. No significant differences were found between genotype or allele frequencies in controls vs. the patient groups. More...

Negative relationships between NPY and other components at different levels (count: 0) Help
NPY related SNPs in MK4MDD (count: 1)
NPY related proteins in MK4MDD (count: 1)
NPY related GO terms (count: 32)
NPY related KEGG pathways (count: 1)
NPY related BioCarta pathways (count: 0)
NPY related Reactome pathways (count: 5)
NPY related interactors from protein-protein interaction data in HPRD (count: 10)