Gene Report

Basic Information

Approved Symbol	NPY
Approved Name	neuropeptide Y
Symbol Alias	PYY4
Name Alias	prepro-neuropeptide Y
Location	7p15.3
Position	chr7:24323807-24331484 (+)
External Links	Entrez Gene: 4852 Ensembl: ENSG00000122585 UCSC: uc003sww.2 HGNC ID: 7955
No. of Studies (Positive/Negative)	6(5/1)
Type	Literature-origin; SNP mapped; Protein mapped

Positive relationships between NPY and MDD (count: 5)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
NPY	Bosker, 2010	patients and normal controls	P-value = 0.034; OR C allele = 0.73, 95% CI 0.55-0.97	associated with MDD (rs16139; P = 0.034; OR C allele = 0.73,...... associated with MDD (rs16139; P = 0.034; OR C allele = 0.73, 95% CI 0.55-0.97) More...
NPY	Heilig M, 2004	Patients and nomal controls		We then explored whether this finding might be related to a ...... We then explored whether this finding might be related to a recently described T1128C coding polymorphism which results in a Leu7-> Pro7 substitution of the signal peptide, and a previously not described T -399C polymorphism in the promoter region of the preproNPY gene. Preliminary evidence was found for an association of both markers with a diagnosis of depression, indicating the possibility of an underlying haplotype influencing the vulnerability for developing depressive illness More...
NPY	Sjoholm LK, 2009	Patients and nomal controls	OR=2.7; P=0.0004	Pro7 alle of NPY was rarer in depression cases than in healt...... Pro7 alle of NPY was rarer in depression cases than in healthy individuals More...
neuropeptide Y (NPY)	Mickey, 2011	patients and normal controls	P-value=0.04	Low-expression NPY genotypes were overrepresented in subject...... Low-expression NPY genotypes were overrepresented in subjects with MDD after controlling for age and sex (P = .004). More...
NPY	Guilloux JP, 2012	patients and normal controls		genes significantly affected in female MDD subjects genes significantly affected in female MDD subjects

Positive relationships between NPY and other components at different levels (count: 2)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description
Name in Literature	Related Components
neuropeptide Y (NPY)		medial prefrontal cortex (MPFC)(medial prefrontal cortex)	brain morphology and function	Mickey, 2011	patients and normal controls	P-value=0.03	Among healthy individuals, negatively valenced words activat...... Among healthy individuals, negatively valenced words activated the medial prefrontal cortex. Activation within this region was inversely related to genotype-predicted NPY expression (P = .03). More...
neuropeptide Y (NPY)		rostral anterior cingulate(rostral anterior cingulate cortex)	brain morphology and function	Mickey, 2011	patients and normal controls	P-value<0.05	Whole-brain regression of responses to negative words showed...... Whole-brain regression of responses to negative words showed that the rostral anterior cingulate cortex activated in the low-expression group and deactivated in the high-expression group (P < .05). More...

Positive relationship network of NPY in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between NPY and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
NPY	Lindberg C, 2006	Patients and nomal controls		We detected the polymorphism -399 C > T at a frequency of 48...... We detected the polymorphism -399 C > T at a frequency of 48% in controls. No significant differences were found between genotype or allele frequencies in controls vs. the patient groups. More...

Negative relationships between NPY and other components at different levels (count: 0)

NPY related SNPs in MK4MDD (count: 2)

#rs	Location	Annotation	No. of Studies (Positive/Negative)
rs16147	chr7:24323410(Forward)	upstream_gene_variant	1(1/0)
rs16139	chr7:24324879(Forward)	missense_variant	1(1/0)

NPY related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Pro-neuropeptide Y	P01303	4(3/1)	Literature-origin

NPY related GO terms (count: 24)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0007268	synaptic transmission	biological process	TAS[10557353]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0021987	cerebral cortex development	biological process	IEP[9067840]
GO:0008343	adult feeding behavior	biological process	ISS
GO:0005102	receptor binding	molecular function	TAS[8132547]
GO:0005246	calcium channel regulator activity	molecular function	TAS[8132547]
GO:0004930	G-protein coupled receptor activity	molecular function	TAS[1321422]
GO:0007631	feeding behavior	biological process	TAS[10698177]
GO:0008217	regulation of blood pressure	biological process	IEA
GO:0005184	neuropeptide hormone activity	molecular function	TAS[2427515]
GO:0006816	calcium ion transport	biological process	TAS[8132547]
GO:0006928	cellular component movement	biological process	TAS[10488139]
GO:0007586	digestion	biological process	NAS[8421707]
GO:0001664	G-protein coupled receptor binding	molecular function	IEA
GO:0021954	central nervous system neuron development	biological process	IEP
GO:0005623	cell	cellular component	TAS[2444979]
GO:0007218	neuropeptide signaling pathway	biological process	IEA
GO:0008283	cell proliferation	biological process	TAS[10488139]
GO:0008015	blood circulation	biological process	NAS[8421707]
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	biological process	TAS[8132547]
GO:0005576	extracellular region	cellular component	TAS
GO:0005615	extracellular space	cellular component	ISS
GO:0031175	neuron projection development	biological process	IEP
GO:0032100	positive regulation of appetite	biological process	ISS
GO:0007610	behavior	biological process	TAS[9845072]

NPY related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04920	adipocytokine signaling_pathway	Adipocytokine signaling pathway	Increased adipocyte volume and number are positively correla...... Increased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and metabolic rate primarily by acting at hypothalamic nuclei. Leptin exerts its anorectic effects by modulating the levels of neuropeptides such as NPY, AGRP, and alpha-MSH. This leptin action is through the JAK kinase, STAT3 phosphorylation, and nuclear transcriptional effect. Adiponectin lowers plasma glucose and FFAs. These effects are partly accounted for by adiponectin-induced AMPK activation, which in turn stimulates skeletal muscle fatty acid oxidation and glucose uptake. Furthermore, activation of AMPK by adiponectin suppresses endogenous glucose production, concomitantly with inhibition of PEPCK and G6Pase expression. The proinflammatory cytokine TNFalpha has been implicated as a link between obesity and insulin resistance. TNFalpha interferes with early steps of insulin signaling. Several data have shown that TNFalpha inhibits IRS1 tyrosine phosphorylation by promoting its serine phosphorylation. Among the serine/threonine kinases activated by TNFalpha, JNK, mTOR and IKK have been shown to be involved in this phosphorylation. More...

NPY related BioCarta pathways (count: 0)

NPY related Reactome pathways (count: 5)

ID	Name	Description
Gene mapped Reactome pathways
REACT_14819	peptide ligand_binding_receptors	These receptors, a subset of the Class A/1 (Rhodopsin-like) ...... These receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins. More...
REACT_19231	g alpha_i_signalling_events	The classical signalling mechanism for G alpha (i) is inhibi...... The classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased activity of cAMP-dependent protein kinases. More...
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...
REACT_14828	class a1_rhodopsin_like_receptors	Rhodopsin-like receptors. They represent members which inclu...... Rhodopsin-like receptors. They represent members which include hormone, light and neurotransmitter receptors and encompass a wide range of functions including many autocrine, paracrine and endocrine processes. More...
REACT_21340	gpcr ligand_binding	There are more than 800 G-protein coupled receptor. GPCRs ar...... There are more than 800 G-protein coupled receptor. GPCRs are receptors for a diverse range of ligands from large proteins to photons and have an equal diverstiy of ligand-binding mechanisms. Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. More...

NPY related interactors from protein-protein interaction data in HPRD (count: 10)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
NPY	NPY1R	No	in vivo	12007534 , 7559383 , 9001438
NPY	PMCH	No	in vitro	12106685
NPY	NPY2R	No	in vivo	9001438 , 7559383 , 12007534
NPY	PPYR1	No	in vitro	7493937
NPY	NPFFR2	No	in vivo	12609745
NPY	NPFF	No	in vivo	11325787
NPY	MC4R	No	in vitro;in vivo	12015205
NPY	MEP1B	No	in vitro	11278902
NPY	GHRL	No	in vivo	11196643 , 12663466
NPY	NPY5R	No	in vivo	12007534

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways