Gene Report

Basic Information

Approved Symbol	CNR2
Approved Name	cannabinoid receptor 2 (macrophage)
Symbol Alias	CB2
Location	1p
Position	chr1:24285413-24285549 (-)
External Links	Entrez Gene: 1269 Ensembl: ENSG00000188822 UCSC: uc001bif.3 HGNC ID: 2160
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between CNR2 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
CNR2	Sequeira, 2007	patients and normal controls		Selected differentially expressed genes in hippocampus Selected differentially expressed genes in hippocampus

Positive relationships between CNR2 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
CNR2		Hippocampus(hippocampus)	brain morphology and function	Sequeira, 2007	patients and normal controls		Selected differentially expressed genes in hippocampus Selected differentially expressed genes in hippocampus

Positive relationship network of CNR2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between CNR2 and MDD (count: 0)

Negative relationships between CNR2 and other components at different levels (count: 0)

CNR2 related SNPs in MK4MDD (count: 0)

CNR2 related proteins in MK4MDD (count: 0)

CNR2 related GO terms (count: 18)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0006954	inflammatory response	biological process	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0051001	negative regulation of nitric-oxide synthase activity	biological process	IEA
GO:0001975	response to amphetamine	biological process	IEA
GO:0032496	response to lipopolysaccharide	biological process	IEA
GO:0005887	integral component of plasma membrane	cellular component	TAS[8679694]
GO:0030425	dendrite	cellular component	IEA
GO:0038171	cannabinoid signaling pathway	biological process	IEA; TAS[8679694]
GO:0045759	negative regulation of action potential	biological process	IEA
GO:0050728	negative regulation of inflammatory response	biological process	IEA
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	biological process	TAS[8679694]
GO:0004949	cannabinoid receptor activity	molecular function	IEA
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	cellular component	IEA
GO:0005886	plasma membrane	cellular component	TAS
GO:0043204	perikaryon	cellular component	IEA
GO:0006955	immune response	biological process	TAS[7556170]
GO:0033004	negative regulation of mast cell activation	biological process	IEA
GO:0032229	negative regulation of synaptic transmission, GABAergic	biological process	IEA
GO:0019233	sensory perception of pain	biological process	IEA

CNR2 related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa04080	neuroactive ligand_receptor_interaction	Neuroactive ligand-receptor interaction

CNR2 related BioCarta pathways (count: 0)

CNR2 related Reactome pathways (count: 4)

ID	Name	Description
Gene mapped Reactome pathways
REACT_21340	gpcr ligand_binding	There are more than 800 G-protein coupled receptor. GPCRs ar...... There are more than 800 G-protein coupled receptor. GPCRs are receptors for a diverse range of ligands from large proteins to photons and have an equal diverstiy of ligand-binding mechanisms. Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. More...
REACT_19231	g alpha_i_signalling_events	The classical signalling mechanism for G alpha (i) is inhibi...... The classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased activity of cAMP-dependent protein kinases. More...
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...
REACT_14828	class a1_rhodopsin_like_receptors	Rhodopsin-like receptors. They represent members which inclu...... Rhodopsin-like receptors. They represent members which include hormone, light and neurotransmitter receptors and encompass a wide range of functions including many autocrine, paracrine and endocrine processes. More...

CNR2 related interactors from protein-protein interaction data in HPRD (count: 1)

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways