Gene Report

Basic Information

Approved Symbol	SST
Approved Name	somatostatin
Symbol Alias	SMST
Name Alias	somatostatin-14, "somatostatin-28"
Location	3q28
Position	chr3:187386694-187388201 (-)
External Links	Entrez Gene: 6750 Ensembl: ENSG00000157005 UCSC: uc003frn.3 HGNC ID: 11329
No. of Studies (Positive/Negative)	2(2/0)
Type	Literature-origin; Protein mapped

Positive relationships between SST and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
neuropeptide somatostatin (SST)	Sibille, 2011	patients and normal controls		MDD subjects demonstrated reduced SST mRNA expression in th...... MDD subjects demonstrated reduced SST mRNA expression in the dorsolateral prefrontal cortex. More...
SST	Guilloux JP, 2012	patients and normal controls		genes significantly affected in female MDD subjects genes significantly affected in female MDD subjects

Positive relationships between SST and other components at different levels (count: 0)

Positive relationship network of SST in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SST and MDD (count: 0)

Negative relationships between SST and other components at different levels (count: 0)

SST related SNPs in MK4MDD (count: 0)

SST related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Somatostatin	P61278	1(1/0)	Literature-origin

SST related GO terms (count: 18)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0007268	synaptic transmission	biological process	TAS[9437026]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0007166	cell surface receptor signaling pathway	biological process	TAS[9437026]
GO:0007584	response to nutrient	biological process	TAS[6145156]
GO:0005615	extracellular space	cellular component	TAS[9437026]
GO:0007267	cell-cell signaling	biological process	TAS[6145156]
GO:0007586	digestion	biological process	TAS[6145156]
GO:0009408	response to heat	biological process	IEA
GO:0030334	regulation of cell migration	biological process	IEA
GO:0005179	hormone activity	molecular function	TAS[9886848]
GO:0043200	response to amino acid stimulus	biological process	IEA
GO:0007186	G-protein coupled receptor signaling pathway	biological process	TAS[8405411]
GO:0006972	hyperosmotic response	biological process	IEA
GO:0008285	negative regulation of cell proliferation	biological process	TAS[9886848]
GO:0042493	response to drug	biological process	IEA
GO:0043025	neuronal cell body	cellular component	IEA
GO:0005576	extracellular region	cellular component	TAS
GO:0008628	hormone-mediated apoptotic signaling pathway	biological process	TAS[8961277]
GO:0048545	response to steroid hormone stimulus	biological process	IEA

SST related KEGG pathways (count: 0)

SST related BioCarta pathways (count: 0)

SST related Reactome pathways (count: 5)

ID	Name	Description
Gene mapped Reactome pathways
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...
REACT_14819	peptide ligand_binding_receptors	These receptors, a subset of the Class A/1 (Rhodopsin-like) ...... These receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins. More...
REACT_19231	g alpha_i_signalling_events	The classical signalling mechanism for G alpha (i) is inhibi...... The classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased activity of cAMP-dependent protein kinases. More...
REACT_21340	gpcr ligand_binding	There are more than 800 G-protein coupled receptor. GPCRs ar...... There are more than 800 G-protein coupled receptor. GPCRs are receptors for a diverse range of ligands from large proteins to photons and have an equal diverstiy of ligand-binding mechanisms. Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. More...
REACT_14828	class a1_rhodopsin_like_receptors	Rhodopsin-like receptors. They represent members which inclu...... Rhodopsin-like receptors. They represent members which include hormone, light and neurotransmitter receptors and encompass a wide range of functions including many autocrine, paracrine and endocrine processes. More...

SST related interactors from protein-protein interaction data in HPRD (count: 5)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
SST	SSTR2	No	in vivo	1346068
SST	SSTR3	No	in vivo	1337145
SST	SSTR1	No	in vivo	1346068
SST	SSTR5	Yes	in vivo	7908405
SST	SSTR4	No	in vivo	8100352

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped Reactome pathways