Gene Report

Basic Information

Approved Symbol	PENK
Approved Name	proenkephalin
Name Alias	preproenkephalin
Location	8q23-q24
Position	chr8:57353513-57359282 (-)
External Links	Entrez Gene: 5179 Ensembl: ENSG00000181195 UCSC: uc003xsz.2 HGNC ID: 8831
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between PENK and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
PENK	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between PENK and other components at different levels (count: 0)

Positive relationship network of PENK in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between PENK and MDD (count: 0)

Negative relationships between PENK and other components at different levels (count: 0)

PENK related SNPs in MK4MDD (count: 0)

PENK related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Proenkephalin-A	P01210	0(0/0)	Gene mapped

PENK related GO terms (count: 7)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0001515	opioid peptide activity	molecular function	IEA
GO:0007218	neuropeptide signaling pathway	biological process	IEA
GO:0005576	extracellular region	cellular component	TAS
GO:0019233	sensory perception of pain	biological process	IEA
GO:0007165	signal transduction	biological process	TAS[7057924]
GO:0001662	behavioral fear response	biological process	IEA
GO:0005184	neuropeptide hormone activity	molecular function	TAS[7057924]

PENK related KEGG pathways (count: 0)

PENK related BioCarta pathways (count: 0)

PENK related Reactome pathways (count: 5)

ID	Name	Description
Gene mapped Reactome pathways
REACT_14828	class a1_rhodopsin_like_receptors	Rhodopsin-like receptors. They represent members which inclu...... Rhodopsin-like receptors. They represent members which include hormone, light and neurotransmitter receptors and encompass a wide range of functions including many autocrine, paracrine and endocrine processes. More...
REACT_19231	g alpha_i_signalling_events	The classical signalling mechanism for G alpha (i) is inhibi...... The classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased activity of cAMP-dependent protein kinases. More...
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...
REACT_21340	gpcr ligand_binding	There are more than 800 G-protein coupled receptor. GPCRs ar...... There are more than 800 G-protein coupled receptor. GPCRs are receptors for a diverse range of ligands from large proteins to photons and have an equal diverstiy of ligand-binding mechanisms. Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. More...
REACT_14819	peptide ligand_binding_receptors	These receptors, a subset of the Class A/1 (Rhodopsin-like) ...... These receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins. More...

PENK related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Gene mapped GO terms

Gene mapped Reactome pathways