Gene Report

Basic Information

Approved Symbol	OPRM1
Approved Name	opioid receptor, mu 1
Symbol Alias	MOR1
Location	6q24-q25
Position	chr6:154567920-154568001 (+)
External Links	Entrez Gene: 4988 Ensembl: ENSG00000112038 UCSC: uc003qpo.1 HGNC ID: 8156
No. of Studies (Positive/Negative)	2(1/1)
Type	Literature-origin; SNP mapped; Protein mapped

Positive relationships between OPRM1 and MDD (count: 0)

Positive relationships between OPRM1 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
OPRM1		Reward processing(Social hedonic capacity)	cognition and behavior	Troisi A, 2011	patients and normal controls		Social hedonic capacity is associated with the A118G polymor...... Social hedonic capacity is associated with the A118G polymorphism of the mu-opioid receptor gene (OPRM1) in adult healthy volunteers and psychiatric patients More...

Positive relationship network of OPRM1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between OPRM1 and MDD (count: 0)

Negative relationships between OPRM1 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description
Name in Literature	Related Components
OPRM1		MDD symptoms(MDD symptoms)	symptoms	Swann, 2014	patients only		There were no significant main effects of differences in OPR...... There were no significant main effects of differences in OPRM1 genotype on MDD symptoms. More...

OPRM1 related SNPs in MK4MDD (count: 2)

#rs	Location	Annotation	No. of Studies (Positive/Negative)
rs562859	chr6:154093438(Forward)		1(0/1)
rs1799971	chr6:154039662(Forward)	regulatory_region_variant	1(0/1)

OPRM1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Mu-type opioid receptor	P35372	1(1/0)	Literature-origin

OPRM1 related GO terms (count: 60)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0007626	locomotory behavior	biological process	IEA
GO:0019233	sensory perception of pain	biological process	IBA; ISS
GO:0042383	sarcolemma	cellular component	IEA
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	biological process	TAS[7905839]
GO:0048149	behavioral response to ethanol	biological process	IMP[21039637]
GO:0005829	cytosol	cellular component	IDA[20214800\|20525224]
GO:0008285	negative regulation of cell proliferation	biological process	TAS[2159143]
GO:0007218	neuropeptide signaling pathway	biological process	IEA; IMP[9689128]
GO:0098794	postsynapse	cellular component	IEA
GO:0031005	filamin binding	molecular function	IEA
GO:0005515	protein binding	molecular function	IPI[14573758\|19788913\|20214800\|23597562\|23840749]
GO:0045019	negative regulation of nitric oxide biosynthetic process	biological process	IDA[20525224]
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	biological process	ISS
GO:0070848	response to growth factor	biological process	IEA
GO:0032496	response to lipopolysaccharide	biological process	IEA
GO:0005783	endoplasmic reticulum	cellular component	TAS[9242668]
GO:0043951	negative regulation of cAMP-mediated signaling	biological process	IDA[20525224]
GO:0002438	acute inflammatory response to antigenic stimulus	biological process	IEA
GO:0032590	dendrite membrane	cellular component	IEA
GO:0038047	morphine receptor activity	molecular function	IBA; ISS
GO:0044849	estrous cycle	biological process	IEA
GO:0005245	voltage-gated calcium channel activity	molecular function	ISS
GO:0001965	G-protein alpha-subunit binding	molecular function	IDA[20214800]
GO:0032100	positive regulation of appetite	biological process	IEA
GO:0050769	positive regulation of neurogenesis	biological process	ISS
GO:0031635	adenylate cyclase-inhibiting opioid receptor signaling pathway	biological process	IEA
GO:0033554	cellular response to stress	biological process	IMP[21039637]
GO:0009314	response to radiation	biological process	IEA
GO:0043005	neuron projection	cellular component	IBA
GO:0043950	positive regulation of cAMP-mediated signaling	biological process	IDA[20214800]
GO:0032839	dendrite cytoplasm	cellular component	IEA
GO:0005794	Golgi apparatus	cellular component	TAS[9242668]
GO:0031681	G-protein beta-subunit binding	molecular function	IBA
GO:0042060	wound healing	biological process	IEA
GO:0045429	positive regulation of nitric oxide biosynthetic process	biological process	IDA[20214800]
GO:0008022	protein C-terminus binding	molecular function	IEA
GO:0042755	eating behavior	biological process	IEA
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	biological process	IEA
GO:0070588	calcium ion transmembrane transport	biological process	IEA
GO:0051481	negative regulation of cytosolic calcium ion concentration	biological process	IDA[20525224]
GO:0042220	response to cocaine	biological process	IEA
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity	biological process	ISS
GO:0004930	G-protein coupled receptor activity	molecular function	ISS
GO:0060079	excitatory postsynaptic potential	biological process	IEA
GO:0007194	negative regulation of adenylate cyclase activity	biological process	ISS
GO:0045121	membrane raft	cellular component	IEA
GO:0043204	perikaryon	cellular component	IEA
GO:0007600	sensory perception	biological process	NAS[9689128]
GO:0019904	protein domain specific binding	molecular function	IEA
GO:0005886	plasma membrane	cellular component	TAS
GO:0070374	positive regulation of ERK1 and ERK2 cascade	biological process	ISS
GO:0007204	positive regulation of cytosolic calcium ion concentration	biological process	IDA[20214800]
GO:0051930	regulation of sensory perception of pain	biological process	IEA
GO:0071315	cellular response to morphine	biological process	IBA
GO:0032094	response to food	biological process	IEA
GO:0005925	focal adhesion	cellular component	IEA
GO:0061358	negative regulation of Wnt protein secretion	biological process	IMP[20214800]
GO:0042923	neuropeptide binding	molecular function	IBA
GO:0004979	beta-endorphin receptor activity	molecular function	IMP[9689128]
GO:0005887	integral component of plasma membrane	cellular component	TAS[7905839]

OPRM1 related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa04080	neuroactive ligand_receptor_interaction	Neuroactive ligand-receptor interaction

OPRM1 related BioCarta pathways (count: 0)

OPRM1 related Reactome pathways (count: 7)

ID	Name	Description
Gene mapped Reactome pathways
REACT_15457	g protein_activation	Receptor activated heterotrimeric G proteins consist of the ...... Receptor activated heterotrimeric G proteins consist of the Galpha and the tightly associated Gbeta-gamma subunits. When a ligand binds to a G protein-coupled receptor, it stabilises a conformation with an high affinity for the G-protein bound to GDP. GDP is then exchanged for GTP on the Galpha subunit. This exchange triggers the dissociation of the Galpha subunit from the Gbeta-gamma dimer and the receptor. Galpha-GTP and Gbeta-gamma, can then modulate different signalling cascades and effector proteins, while the receptor is able to activate another G protein, resulting in an amplification cascade. The Galpha subunit will eventually hydrolyze the attached GTP to GDP by its inherent enzymatic activity, allowing it to reassociate with Gbeta-gamma and start a new cycle. More...
REACT_14819	peptide ligand_binding_receptors	These receptors, a subset of the Class A/1 (Rhodopsin-like) ...... These receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins. More...
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...
REACT_15295	opioid signalling	Opioids are chemical substances similar to opiates, the acti...... Opioids are chemical substances similar to opiates, the active substances found in opium (morphine, codeine etc.). Opioid action is mediated by the receptors for endogenous opioids; peptides such as the enkephalins, the endorphins or the dynorphins. Opioids possess powerful analgesic and sedative effects, and are widely used as pain-killers. Their main side-effect is the rapid establishment of a strong addiction. Opioids receptors are G-protein coupled receptors (GPCR). There are four classes of receptors: mu (MOR), kappa (KOR) and delta (DOR), and the nociceptin receptor (NOP). More...
REACT_21340	gpcr ligand_binding	There are more than 800 G-protein coupled receptor. GPCRs ar...... There are more than 800 G-protein coupled receptor. GPCRs are receptors for a diverse range of ligands from large proteins to photons and have an equal diverstiy of ligand-binding mechanisms. Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. More...
REACT_19231	g alpha_i_signalling_events	The classical signalling mechanism for G alpha (i) is inhibi...... The classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased activity of cAMP-dependent protein kinases. More...
REACT_14828	class a1_rhodopsin_like_receptors	Rhodopsin-like receptors. They represent members which inclu...... Rhodopsin-like receptors. They represent members which include hormone, light and neurotransmitter receptors and encompass a wide range of functions including many autocrine, paracrine and endocrine processes. More...

OPRM1 related interactors from protein-protein interaction data in HPRD (count: 12)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
OPRM1	PPL	No	in vitro;in vivo;yeast 2-hybrid	12810704
OPRM1	OPRD1	No	in vivo	11069979
OPRM1	GNAI1	Yes	in vivo	12068084
OPRM1	GNAI2	No	in vivo	12068084
OPRM1	ADRBK2	No	in vitro	11060299
OPRM1	PLD2	No	in vitro;in vivo	12519790
OPRM1	CALM1	Yes	in vitro;in vivo	11457836
OPRM1	GNA15	No	in vivo	9572309
OPRM1	GNAO1	No	in vivo	8393523
OPRM1	FLNA	No	in vitro;in vivo;yeast 2-hybrid	14573758
OPRM1	GPRASP1	No	in vitro;in vivo;yeast 2-hybrid	12142540
OPRM1	DNAJB4	No	in vitro;in vivo;yeast 2-hybrid	16542645

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways