MK4MDD

Gene Report

Basic Information
Approved Symbol CHRM2
Approved Name cholinergic receptor, muscarinic 2
Name Alias "acetylcholine receptor, muscarinic 2"
Location 7q35-q36
Position chr7:136701014-136701771 (+)
External Links Entrez Gene: 1129
Ensembl: ENSG00000181072
UCSC: uc003vtl.1
HGNC ID: 1951
No. of Studies (Positive/Negative) 2(1/1) Help
Type Literature-origin; Protein mapped

Positive relationships between CHRM2 and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description Help
CHRM2 Comings, 2002 patients and normal controls P-value=0.01 There was a significant increase in the frequency of 11 homo...... There was a significant increase in the frequency of 11 homozygotes in 126 women with major depression (43.7%) compared to 304 women without major depression (25.7%), P =.001. More...

Positive relationships between CHRM2 and other components at different levels (count: 0) Help
Positive relationship network of CHRM2 in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between CHRM2 and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description
CHRM2 Cohen-Woods S, 2009 Patients and nomal controls Our data fail to support association with the CHRM2 polymorp...... Our data fail to support association with the CHRM2 polymorphisms previously implicated in the genetic aetiology of depression. More...

Negative relationships between CHRM2 and other components at different levels (count: 0) Help
CHRM2 related SNPs in MK4MDD (count: 0)
CHRM2 related proteins in MK4MDD (count: 1)
CHRM2 related GO terms (count: 23)
CHRM2 related KEGG pathways (count: 3)
CHRM2 related BioCarta pathways (count: 0)
CHRM2 related Reactome pathways (count: 5)
CHRM2 related interactors from protein-protein interaction data in HPRD (count: 8)