Gene Report

Basic Information

Approved Symbol	CHRM2
Approved Name	cholinergic receptor, muscarinic 2
Name Alias	"acetylcholine receptor, muscarinic 2"
Location	7q35-q36
Position	chr7:136701014-136701771 (+)
External Links	Entrez Gene: 1129 Ensembl: ENSG00000181072 UCSC: uc003vtl.1 HGNC ID: 1951
No. of Studies (Positive/Negative)	2(1/1)
Type	Literature-origin; Protein mapped

Positive relationships between CHRM2 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
CHRM2	Comings, 2002	patients and normal controls	P-value=0.01	There was a significant increase in the frequency of 11 homo...... There was a significant increase in the frequency of 11 homozygotes in 126 women with major depression (43.7%) compared to 304 women without major depression (25.7%), P =.001. More...

Positive relationships between CHRM2 and other components at different levels (count: 0)

Positive relationship network of CHRM2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between CHRM2 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
CHRM2	Cohen-Woods S, 2009	Patients and nomal controls		Our data fail to support association with the CHRM2 polymorp...... Our data fail to support association with the CHRM2 polymorphisms previously implicated in the genetic aetiology of depression. More...

Negative relationships between CHRM2 and other components at different levels (count: 0)

CHRM2 related SNPs in MK4MDD (count: 0)

CHRM2 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Muscarinic acetylcholine receptor M2	P08172	1(1/0)	Literature-origin

CHRM2 related GO terms (count: 23)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0030054	cell junction	cellular component	IEA
GO:0045211	postsynaptic membrane	cellular component	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0007186	G-protein coupled receptor signaling pathway	biological process	TAS[9603968]
GO:0009615	response to virus	biological process	IEP[16548883]
GO:0007271	synaptic transmission, cholinergic	biological process	IBA
GO:0005887	integral component of plasma membrane	cellular component	IDA[24256733]
GO:0016907	G-protein coupled acetylcholine receptor activity	molecular function	IDA[24256733]
GO:0006940	regulation of smooth muscle contraction	biological process	IBA
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	biological process	TAS[10895079]
GO:0008144	drug binding	molecular function	IEA
GO:0007197	adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway	biological process	IBA
GO:0043025	neuronal cell body	cellular component	IEA
GO:0043679	axon terminus	cellular component	IEA
GO:0008016	regulation of heart contraction	biological process	IEA
GO:0030425	dendrite	cellular component	IEA
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	biological process	TAS[8139539]
GO:0007399	nervous system development	biological process	TAS[2739737]
GO:0032279	asymmetric synapse	cellular component	IEA
GO:0007213	G-protein coupled acetylcholine receptor signaling pathway	biological process	IDA[24256733]
GO:0007207	phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway	biological process	TAS[2739737]
GO:0032280	symmetric synapse	cellular component	IEA
GO:0005886	plasma membrane	cellular component	IDA; TAS
GO:0045202	synapse	cellular component	IBA

CHRM2 related KEGG pathways (count: 3)

ID	Name	Brief Description	Full Description
Literature-origin KEGG pathway
hsa04810	regulation of_actin_cytoskeleton	Regulation of actin cytoskeleton
hsa04020	calcium signaling_pathway	Calcium signaling pathway	Ca2+ that enters the cell from the outside is a principal so...... Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs). The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it. The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM). More...

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04080	neuroactive ligand_receptor_interaction	Neuroactive ligand-receptor interaction

CHRM2 related BioCarta pathways (count: 0)

CHRM2 related Reactome pathways (count: 5)

ID	Name	Description
Gene mapped Reactome pathways
REACT_19231	g alpha_i_signalling_events	The classical signalling mechanism for G alpha (i) is inhibi...... The classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased activity of cAMP-dependent protein kinases. More...
REACT_16983	amine ligand_binding_receptors	The class A (rhodopsin-like) GPCRs that bind to classical bi...... The class A (rhodopsin-like) GPCRs that bind to classical biogenic amine ligands are annotated here. The amines involved (acetylcholine, adrenaline, noradrenaline, dopamine, serotonin and histamine) can all act as neurotransmitters in humans. The so-called 'trace amines', used when referring to p-tyramine, beta-phenylethylamine, tryptamine and octopamine, can also bind to recently-discovered GPCRs. More...
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...
REACT_21340	gpcr ligand_binding	There are more than 800 G-protein coupled receptor. GPCRs ar...... There are more than 800 G-protein coupled receptor. GPCRs are receptors for a diverse range of ligands from large proteins to photons and have an equal diverstiy of ligand-binding mechanisms. Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. More...
REACT_14828	class a1_rhodopsin_like_receptors	Rhodopsin-like receptors. They represent members which inclu...... Rhodopsin-like receptors. They represent members which include hormone, light and neurotransmitter receptors and encompass a wide range of functions including many autocrine, paracrine and endocrine processes. More...

CHRM2 related interactors from protein-protein interaction data in HPRD (count: 8)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
CHRM2	GNA14	No	in vivo	7797501
CHRM2	SAG	No	in vivo	10952973
CHRM2	GRK5	No	in vitro	8288567
CHRM2	GNA11	No	in vivo	7797501
CHRM2	CHRM2	Yes	in vitro	15255931
CHRM2	GNA15	No	in vitro	7797501
CHRM2	GPRASP2	No	in vitro	15086532
CHRM2	GNG2	No	in vivo	9063897

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Literature-origin KEGG pathway

Gene mapped KEGG pathways

Gene mapped Reactome pathways