Gene Report

Basic Information

Approved Symbol	DRD4
Approved Name	dopamine receptor D4
Location	11p15.5
Position	chr11:637305-640706 (+)
External Links	Entrez Gene: 1815 Ensembl: ENSG00000069696 UCSC: uc001lqp.2 HGNC ID: 3025
No. of Studies (Positive/Negative)	2(0/2)
Type	Literature-origin

Positive relationships between DRD4 and MDD (count: 0)

Positive relationships between DRD4 and other components at different levels (count: 0)

Positive relationship network of DRD4 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between DRD4 and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
DRD4	Serretti A, 2001	Patients and nomal controls		DRD4 allele and genotype frequencies in bipolars, schizophre...... DRD4 allele and genotype frequencies in bipolars, schizophrenics, delusionals, and psychotic NOS were not significantly different from controls; major depressives showed a trend toward an excess of DRD4Short and DRD4Short/Short variants versus controls. More...
DRD4	Aguirre AJ, 2007	Patients and nomal controls		There were no differences in allele or genotype frequencies...... There were no differences in allele or genotype frequencies between groups for the 12 bp-VNTR polymorphisms More...

Negative relationships between DRD4 and other components at different levels (count: 0)

DRD4 related SNPs in MK4MDD (count: 0)

DRD4 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
D(4) dopamine receptor	P21917	0(0/0)	Gene mapped

DRD4 related GO terms (count: 43)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0001963	synaptic transmission, dopaminergic	biological process	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0000187	activation of MAPK activity	biological process	IDA[15755724]
GO:0042417	dopamine metabolic process	biological process	IC[1840645]
GO:0004952	dopamine neurotransmitter receptor activity	molecular function	IDA[8413587]
GO:0046928	regulation of neurotransmitter secretion	biological process	IEA
GO:0008344	adult locomotory behavior	biological process	ISS
GO:0043025	neuronal cell body	cellular component	IEA
GO:0032417	positive regulation of sodium:hydrogen antiporter activity	biological process	IDA[7512953]
GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	molecular function	IDA[1840645]; ISS
GO:0017124	SH3 domain binding	molecular function	IDA[9843378]
GO:0048149	behavioral response to ethanol	biological process	TAS[12888781]
GO:0007614	short-term memory	biological process	IEA
GO:0043197	dendritic spine	cellular component	IEA
GO:0015459	potassium channel regulator activity	molecular function	NAS[12297500]
GO:0034776	response to histamine	biological process	IDA[16839358]
GO:0005886	plasma membrane	cellular component	TAS
GO:0005887	integral to plasma membrane	cellular component	IDA[15755724]
GO:1901386	negative regulation of voltage-gated calcium channel activity	biological process	IDA[7921596]
GO:0035240	dopamine binding	molecular function	IDA[1319557]
GO:0005515	protein binding	molecular function	IPI[12297500]
GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	biological process	IDA[7512953]
GO:0012506	vesicle membrane	cellular component	IEA
GO:0007212	dopamine receptor signaling pathway	biological process	IDA[1840645]
GO:0033674	positive regulation of kinase activity	biological process	IDA[15755724]
GO:0043195	terminal bouton	cellular component	IEA
GO:0048148	behavioral response to cocaine	biological process	ISS
GO:0005938	cell cortex	cellular component	IEA
GO:0042596	fear response	biological process	ISS
GO:0001662	behavioral fear response	biological process	NAS[12860355]
GO:0001975	response to amphetamine	biological process	ISS
GO:0050709	negative regulation of protein secretion	biological process	IDA[16839358]
GO:0042053	regulation of dopamine metabolic process	biological process	ISS
GO:0035176	social behavior	biological process	NAS[11409696]
GO:0008144	drug binding	molecular function	IDA[8413587]
GO:0006874	cellular calcium ion homeostasis	biological process	IC[7921596]
GO:0007194	negative regulation of adenylate cyclase activity	biological process	IDA[7512953]
GO:0016020	membrane	cellular component	IDA[7512953]
GO:0008355	olfactory learning	biological process	IEA
GO:0051586	positive regulation of dopamine uptake involved in synaptic transmission	biological process	IC[1840645]
GO:0050482	arachidonic acid secretion	biological process	IDA[7512953]
GO:0030818	negative regulation of cAMP biosynthetic process	biological process	IDA[7512953]
GO:0050848	regulation of calcium-mediated signaling	biological process	IEA
GO:0060080	regulation of inhibitory postsynaptic membrane potential	biological process	ISS

DRD4 related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa04080	neuroactive ligand_receptor_interaction	Neuroactive ligand-receptor interaction

DRD4 related BioCarta pathways (count: 0)

DRD4 related Reactome pathways (count: 5)

ID	Name	Description
Gene mapped Reactome pathways
REACT_21340	gpcr ligand_binding	There are more than 800 G-protein coupled receptor. GPCRs ar...... There are more than 800 G-protein coupled receptor. GPCRs are receptors for a diverse range of ligands from large proteins to photons and have an equal diverstiy of ligand-binding mechanisms. Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. More...
REACT_14828	class a1_rhodopsin_like_receptors	Rhodopsin-like receptors. They represent members which inclu...... Rhodopsin-like receptors. They represent members which include hormone, light and neurotransmitter receptors and encompass a wide range of functions including many autocrine, paracrine and endocrine processes. More...
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...
REACT_19231	g alpha_i_signalling_events	The classical signalling mechanism for G alpha (i) is inhibi...... The classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased activity of cAMP-dependent protein kinases. More...
REACT_16983	amine ligand_binding_receptors	The class A (rhodopsin-like) GPCRs that bind to classical bi...... The class A (rhodopsin-like) GPCRs that bind to classical biogenic amine ligands are annotated here. The amines involved (acetylcholine, adrenaline, noradrenaline, dopamine, serotonin and histamine) can all act as neurotransmitters in humans. The so-called 'trace amines', used when referring to p-tyramine, beta-phenylethylamine, tryptamine and octopamine, can also bind to recently-discovered GPCRs. More...

DRD4 related interactors from protein-protein interaction data in HPRD (count: 6)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
DRD4	NCK1	No	in vivo	9843378
DRD4	GABRA1	Yes	in vitro	10050966
DRD4	KCNJ9	No	in vitro;in vivo	12297500
DRD4	KLHL12	No	in vivo;yeast 2-hybrid	18303015
DRD4	CLIC6	Yes	in vivo;yeast 2-hybrid	14499480
DRD4	GRB2	No	in vivo	9843378

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways