Gene Report

Basic Information

Approved Symbol	GABBR2
Approved Name	gamma-aminobutyric acid (GABA) B receptor, 2
Previous Symbol	GPR51
Previous Name	"G protein-coupled receptor 51"
Symbol Alias	HG20, GABABR2, GPRC3B
Location	9q22.1-q22.3
Position	chr9:101471020-101471479 (-)
External Links	Entrez Gene: 9568 Ensembl: ENSG00000136928 UCSC: uc004ays.3 HGNC ID: 4507
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin; Protein mapped

Positive relationships between GABBR2 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
GABBR2	Klempan, 2009	patients and normal controls		Selected differentially expressed genes in BA44 to BA47 (ANO...... Selected differentially expressed genes in BA44 to BA47 (ANOVA and t-test P < 0.01, fold change 1.3t) More...

Positive relationships between GABBR2 and other components at different levels (count: 0)

Positive relationship network of GABBR2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between GABBR2 and MDD (count: 0)

Negative relationships between GABBR2 and other components at different levels (count: 0)

GABBR2 related SNPs in MK4MDD (count: 0)

GABBR2 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Gamma-aminobutyric acid type B receptor	Q9UBS5; O75899	1(1/0)	Literature-origin

GABBR2 related GO terms (count: 13)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0045211	postsynaptic membrane	cellular component	IEA
GO:0030054	cell junction	cellular component	IEA
GO:0004965	G-protein coupled GABA receptor activity	molecular function	IDA[9872316]
GO:0007268	synaptic transmission	biological process	TAS

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0007194	negative regulation of adenylate cyclase activity	biological process	TAS[10328880]
GO:0005887	integral component of plasma membrane	cellular component	IDA[9872316]
GO:0005737	cytoplasm	cellular component	IEA
GO:0007186	G-protein coupled receptor signaling pathway	biological process	TAS[9872316]
GO:0043005	neuron projection	cellular component	IEA
GO:0007214	gamma-aminobutyric acid signaling pathway	biological process	IDA[9872316]
GO:0038039	G-protein coupled receptor heterodimeric complex	cellular component	IPI[9872316]
GO:0005515	protein binding	molecular function	IPI[16724110\|24658140]
GO:0005886	plasma membrane	cellular component	TAS

GABBR2 related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa04080	neuroactive ligand_receptor_interaction	Neuroactive ligand-receptor interaction

GABBR2 related BioCarta pathways (count: 0)

GABBR2 related Reactome pathways (count: 4)

ID	Name	Description
Gene mapped Reactome pathways
REACT_19231	g alpha_i_signalling_events	The classical signalling mechanism for G alpha (i) is inhibi...... The classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased activity of cAMP-dependent protein kinases. More...
REACT_18319	class c3_metabotropic_glutamate_pheromone_receptors	The class C G-protein-coupled receptors are a class of G-pro...... The class C G-protein-coupled receptors are a class of G-protein coupled receptors that include the metabotropic glutamate receptors and several additional receptors. Family C GPCRs have a large extracellular N-terminus which binds the orthosteric (endogenous) ligand. The shape of this domain is often likened to a clam. Several allosteric ligands to these receptors have been identified and these bind within the seven transmembrane region. More...
REACT_21340	gpcr ligand_binding	There are more than 800 G-protein coupled receptor. GPCRs ar...... There are more than 800 G-protein coupled receptor. GPCRs are receptors for a diverse range of ligands from large proteins to photons and have an equal diverstiy of ligand-binding mechanisms. Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. More...
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...

GABBR2 related interactors from protein-protein interaction data in HPRD (count: 7)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
GABBR2	ATF4	No	yeast 2-hybrid	11087824
GABBR2	HTR1A	Yes	in vivo	11854302
GABBR2	SH3GL3	No	yeast 2-hybrid	16169070
GABBR2	GRASP	No	yeast 2-hybrid	11850456
GABBR2	NSF	No	in vitro;in vivo;yeast 2-hybrid	16724110
GABBR2	ATF5	No	yeast 2-hybrid	11087824
GABBR2	GABBR1	Yes	in vitro;in vivo;yeast 2-hybrid	10075644 , 9872316

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways