Gene Report

Basic Information

Approved Symbol	PROKR2
Approved Name	prokineticin receptor 2
Previous Symbol	GPR73L1, KAL3
Previous Name	G protein-coupled receptor 73-like 1, "Kallmann syndrome 3 (autosomal dominant)"
Symbol Alias	GPR73b, PKR2, GPRg2, dJ680N4.3
Location	20p12.3
Position	chr20:5282686-5295015 (-)
External Links	Entrez Gene: 128674 Ensembl: ENSG00000101292 UCSC: uc010zqw.2 HGNC ID: 15836
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between PROKR2 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
PROKR2	Kishi, 2009	patients and normal controls		We detected a significant association between PROKR2 and maj...... We detected a significant association between PROKR2 and major depressive disorder and bipolar disorder in the Japanese population. More...

Positive relationships between PROKR2 and other components at different levels (count: 0)

Positive relationship network of PROKR2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between PROKR2 and MDD (count: 0)

Negative relationships between PROKR2 and other components at different levels (count: 0)

PROKR2 related SNPs in MK4MDD (count: 0)

PROKR2 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Prokineticin receptor 2	Q8NFJ6	0(0/0)	Gene mapped

PROKR2 related GO terms (count: 4)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0016021	integral to membrane	cellular component	IEA
GO:0005886	plasma membrane	cellular component	TAS
GO:0004983	neuropeptide Y receptor activity	molecular function	IEA
GO:0007623	circadian rhythm	biological process	IEA

PROKR2 related KEGG pathways (count: 0)

PROKR2 related BioCarta pathways (count: 0)

PROKR2 related Reactome pathways (count: 5)

ID	Name	Description
Gene mapped Reactome pathways
REACT_14819	peptide ligand_binding_receptors	These receptors, a subset of the Class A/1 (Rhodopsin-like) ...... These receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins. More...
REACT_18283	g alpha_q_signalling_events	The classic signalling route for G alpha (q) is activation o...... The classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides a path to calcium-regulated kinases and phosphatases, GEFs, MAP kinase cassettes and other proteins that mediate cellular responses ranging from granule secretion, integrin activation, and aggregation in platelets. Gq participates in many other signalling events including direct interaction with RhoGEFs that stimulate RhoA activity and inhibition of PI3K. Both in vitro and in vivo, the G-protein Gq seems to be the predominant mediator of the activation of platelets. More...
REACT_21340	gpcr ligand_binding	There are more than 800 G-protein coupled receptor. GPCRs ar...... There are more than 800 G-protein coupled receptor. GPCRs are receptors for a diverse range of ligands from large proteins to photons and have an equal diverstiy of ligand-binding mechanisms. Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. More...
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...
REACT_14828	class a1_rhodopsin_like_receptors	Rhodopsin-like receptors. They represent members which inclu...... Rhodopsin-like receptors. They represent members which include hormone, light and neurotransmitter receptors and encompass a wide range of functions including many autocrine, paracrine and endocrine processes. More...

PROKR2 related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Gene mapped GO terms

Gene mapped Reactome pathways