Gene Report

Basic Information

Approved Symbol	TAC1
Approved Name	tachykinin, precursor 1
Previous Symbol	TAC2, NKNA
Previous Name	tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)
Symbol Alias	NPK
Name Alias	substance K, "substance P", "neurokinin 1", "neurokinin 2", "neuromedin L", "neurokinin alpha", "neuropeptide K", "neuropeptide gamma", "preprotachykinin"
Location	7q21-q22
Position	chr7:97361271-97369784 (+)
External Links	Entrez Gene: 6863 Ensembl: ENSG00000006128 UCSC: uc003uop.4 HGNC ID: 11517
No. of Studies (Positive/Negative)	2(2/0)
Type	Literature-origin; Protein mapped

Positive relationships between TAC1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
TAC1	Guilloux JP, 2012	patients and normal controls		genes significantly affected in female MDD subjects genes significantly affected in female MDD subjects

Positive relationships between TAC1 and other components at different levels (count: 4)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Relation Description
Name in Literature	Related Components
tac1		Corticoliberin(CRH, corticosteron releasing hormone)	protein	Frisch, 2010	animal model	Our results show a strong induction of CRH expression in the...... Our results show a strong induction of CRH expression in the cortex of tac1(-/-) animals. More...
tac1		Corticotropin-releasing factor-binding protein(CRHBP, corticosteron releasing hormone binding protein)	protein	Frisch, 2010	animal model	Our results show a strong induction of CRHBP expression in t...... Our results show a strong induction of CRHBP expression in the cortex of tac2(-/-) animals. More...
tac1		Corticotropin-releasing factor receptor 1(CRHR1, corticosteron releasing hormone receptor 1)	protein	Frisch, 2010	animal model	Our results show a strong induction of CRHR1 expression in t...... Our results show a strong induction of CRHR1 expression in the cortex of tac3(-/-) animals. More...
tac1		Protachykinin-1(substance P)	protein	Frisch, 2010	animal model	coding gene coding gene

Positive relationship network of TAC1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between TAC1 and MDD (count: 0)

Negative relationships between TAC1 and other components at different levels (count: 0)

TAC1 related SNPs in MK4MDD (count: 0)

TAC1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Protachykinin-1	P20366	2(2/0)	Literature-origin

TAC1 related GO terms (count: 33)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0006954	inflammatory response	biological process	IEA
GO:0007268	synaptic transmission	biological process	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0009582	detection of abiotic stimulus	biological process	TAS[9482938]
GO:0007218	neuropeptide signaling pathway	biological process	IEA
GO:0007217	tachykinin receptor signaling pathway	biological process	IEA
GO:0043278	response to morphine	biological process	IEA
GO:2000854	positive regulation of corticosterone secretion	biological process	IEA
GO:0030424	axon	cellular component	IEA
GO:0045760	positive regulation of action potential	biological process	IEA
GO:0019233	sensory perception of pain	biological process	IEA
GO:0002675	positive regulation of acute inflammatory response	biological process	IEA
GO:0035815	positive regulation of renal sodium excretion	biological process	IEA
GO:0008217	regulation of blood pressure	biological process	IEA
GO:0032496	response to lipopolysaccharide	biological process	IEA
GO:0043025	neuronal cell body	cellular component	IEA
GO:0048265	response to pain	biological process	IEA
GO:0032224	positive regulation of synaptic transmission, cholinergic	biological process	IEA
GO:0031835	substance P receptor binding	molecular function	IEA
GO:0005576	extracellular region	cellular component	TAS
GO:0032230	positive regulation of synaptic transmission, GABAergic	biological process	IEA
GO:0046878	positive regulation of saliva secretion	biological process	IEA
GO:0051496	positive regulation of stress fiber assembly	biological process	IEA
GO:0007267	cell-cell signaling	biological process	TAS[1708336]
GO:0050671	positive regulation of lymphocyte proliferation	biological process	IEA
GO:0007320	insemination	biological process	TAS[1708336]
GO:0009725	response to hormone stimulus	biological process	IEA
GO:0008306	associative learning	biological process	IEA
GO:0010634	positive regulation of epithelial cell migration	biological process	IEA
GO:0005615	extracellular space	cellular component	IEA
GO:0007204	elevation of cytosolic calcium ion concentration	biological process	IDA[8957234]
GO:0010459	negative regulation of heart rate	biological process	IEA
GO:0005886	plasma membrane	cellular component	IEA
GO:0007616	long-term memory	biological process	IEA

TAC1 related KEGG pathways (count: 0)

TAC1 related BioCarta pathways (count: 0)

TAC1 related Reactome pathways (count: 5)

ID	Name	Description
Gene mapped Reactome pathways
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...
REACT_18283	g alpha_q_signalling_events	The classic signalling route for G alpha (q) is activation o...... The classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides a path to calcium-regulated kinases and phosphatases, GEFs, MAP kinase cassettes and other proteins that mediate cellular responses ranging from granule secretion, integrin activation, and aggregation in platelets. Gq participates in many other signalling events including direct interaction with RhoGEFs that stimulate RhoA activity and inhibition of PI3K. Both in vitro and in vivo, the G-protein Gq seems to be the predominant mediator of the activation of platelets. More...
REACT_14819	peptide ligand_binding_receptors	These receptors, a subset of the Class A/1 (Rhodopsin-like) ...... These receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins. More...
REACT_14828	class a1_rhodopsin_like_receptors	Rhodopsin-like receptors. They represent members which inclu...... Rhodopsin-like receptors. They represent members which include hormone, light and neurotransmitter receptors and encompass a wide range of functions including many autocrine, paracrine and endocrine processes. More...
REACT_21340	gpcr ligand_binding	There are more than 800 G-protein coupled receptor. GPCRs ar...... There are more than 800 G-protein coupled receptor. GPCRs are receptors for a diverse range of ligands from large proteins to photons and have an equal diverstiy of ligand-binding mechanisms. Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. More...

TAC1 related interactors from protein-protein interaction data in HPRD (count: 7)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
TAC1	BAT3	No	yeast 2-hybrid	16169070
TAC1	TACR3	No	in vivo	9272936
TAC1	TACR1	No	in vivo	12548712
TAC1	TACR2	No	in vivo	7961636 , 10189055
TAC1	FN1	No	in vitro	11342427
TAC1	MEP1A	No	in vitro	11278902
TAC1	PREP	No	in vitro	12603817

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped Reactome pathways