Gene Report

Basic Information

Approved Symbol	KCNK2
Approved Name	potassium channel, subfamily K, member 2
Symbol Alias	K2p2.1, TREK-1
Location	1q41
Position	chr1:215178885-215410436 (+)
External Links	Entrez Gene: 3776 Ensembl: ENSG00000082482 UCSC: uc001hkr.4 HGNC ID: 6277
No. of Studies (Positive/Negative)	2(2/0)
Type	Literature-origin; SNP mapped

Positive relationships between KCNK2 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
KCNK2	Liou, 2009	patients and normal controls		The genotype frequency of rs6686529 in this gene differed si...... The genotype frequency of rs6686529 in this gene differed significantly between the MDD patients and controls (uncorrected P = 0.00052) and remained statistically significant after correction for multiple comparisons. More...

Positive relationships between KCNK2 and other components at different levels (count: 5)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Relation Description
Name in Literature	Related Components
TREK1		dorsal anterior cingulate cortex(dorsal anterior cingulate cortex)	brain morphology and function	Dillon, 2010	normal people	the total number of protective TREK1 alleles was associated ...... the total number of protective TREK1 alleles was associated with stronger responses to gains in several other reward-related regions, including the dorsal anterior cingulate cortex. More...
TREK1		medial prefrontal cortex (MPFC)(mesial prefrontal cortex)	brain morphology and function	Dillon, 2010	normal people	the total number of protective TREK1 alleles was associated ...... the total number of protective TREK1 alleles was associated with stronger responses to gains in several other reward-related regions, including the mesial prefrontal cortex. More...
TREK1		Orbitofrontal cortex(orbitofrontal cortex)	brain morphology and function	Dillon, 2010	normal people	the total number of protective TREK1 alleles was associated ...... the total number of protective TREK1 alleles was associated with stronger responses to gains in several other reward-related regions, including the orbitofrontal cortex. More...
TREK1		Reward system(brain reward system)	brain morphology and function	Dillon, 2010	normal people	Results revealed that TREK1 and DAT/COMT genotypes were inde...... Results revealed that TREK1 and DAT/COMT genotypes were independently related to basal ganglia responses to gains. These findings indicate that TREK1 genotypes are associated with individual differences in reward-related brain activity. More...
TREK1		Anhedonia(anhedonia)	symptoms	Dillon, 2010	normal people	TREK1 genetic variations did not affect basal ganglia volume...... TREK1 genetic variations did not affect basal ganglia volume, and fMRI group differences were confirmed when accounting for self-report measures of anhedonia. More...

Positive relationship network of KCNK2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between KCNK2 and MDD (count: 0)

Negative relationships between KCNK2 and other components at different levels (count: 0)

KCNK2 related SNPs in MK4MDD (count: 1)

#rs	Location	Annotation	No. of Studies (Positive/Negative)
rs6686529	chr1:215410106(Forward)	3_prime_UTR_variant; downstream_gene_variant	1(1/0)

KCNK2 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Potassium channel subfamily K member 2	O95069	0(0/0)	Gene mapped

KCNK2 related GO terms (count: 7)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0007268	synaptic transmission	biological process	TAS

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IEA
GO:0016020	membrane	cellular component	NAS
GO:0005886	plasma membrane	cellular component	TAS
GO:0006813	potassium ion transport	biological process	NAS
GO:0008076	voltage-gated potassium channel complex	cellular component	IEA
GO:0015271	outward rectifier potassium channel activity	molecular function	NAS

KCNK2 related KEGG pathways (count: 0)

KCNK2 related BioCarta pathways (count: 0)

KCNK2 related Reactome pathways (count: 0)

KCNK2 related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Literature-origin GO terms

Gene mapped GO terms