Molecule Report

Name	N-acetylaspartate
Description	The second-most-concentrated molecule in the brain after the amino acid glutamate. It is synthesized in neurons from the amino acid aspartic acid and acetyl-coenzyme A.
MeSH ID	C000179
No. of Studies (Positive/Negative)	10(9/1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
N-acetyl-L-aspartate (NAA)	Vythilingam, 2003	patients and normal controls		Compared with control subjects, MDD patients had a significa...... Compared with control subjects, MDD patients had a significantly lower mean NAA/Cr amplitude in the caudate and a significantly higher mean Cho/Cr amplitude in the putamen, particularly on the right side. More...
N-acetyl-aspartate	MacMaster, 2008	patients and normal controls		N-acetyl-aspartate was lower in the left MTC (27%) in MDD pa...... N-acetyl-aspartate was lower in the left MTC (27%) in MDD patients versus controls. More...
N-acetylaspartate (NAA)	Chen, 2009	patients and normal controls		Patients with late-life major depressive disorder had a sign...... Patients with late-life major depressive disorder had a significantly lower NAA/creatine ratio in the left frontal white matter when compared with the control subjects. More...
N-acetylaspartate	Walter, 2009	patients and normal controls		N-acetylaspartate concentrations in pgACC correlate with neg...... N-acetylaspartate concentrations in pgACC correlate with negative BOLD responses induced by emotional stimulation in MDD More...
N-acetylaspartate (NAA)	Chen, 2010	patients only	rho=0.31; P-value<0.006	Total scores of MDIS (Mood Disorders Insight Scale) correlat...... Total scores of MDIS (Mood Disorders Insight Scale) correlated with NAA/tCr (rho=0.31; p<0.006) in the left frontal lobe. Secondary analyses showed the depressive elders with inadequate attribution to their disease had lower levels of NAA/tCr than those with full insight regarding attribution. More...
N-acetylaspartate (NAA)	Reynolds, 2011	patients and normal controls		In the amygdala there are significant NAA deficits in schizo...... In the amygdala there are significant NAA deficits in schizophrenia and depression group. More...
N-acetyl-aspartate (NAA)	Olvera, 2010	patients and normal controls		MDD subjects showed significantly lower levels of NAA in the...... MDD subjects showed significantly lower levels of NAA in the right MPFC and right AC than controls. More...
N-acetylaspartate	Portella, 2011	patients and normal controls	r = 0.50; P-value = 0.001	Total-NAA levels were significantly lowered in remitted-recu...... Total-NAA levels were significantly lowered in remitted-recurrent and chronic patients, which were associated with an earlier age at onset (r = 0.50; p = 0.001). More...
N-acetylaspartate	Jarnum, 2011	patients and normal controls		significantly reduced N-acetylaspartate levels in MDD patien...... significantly reduced N-acetylaspartate levels in MDD patients compared with healthy controls at baseline. More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
N-acetyl-aspartate		medial temporal regions(medial temporal cortex (MTC))	brain morphology and function	MacMaster, 2008	patients and normal controls		N-acetyl-aspartate was lower in the left MTC (27%) in MDD pa...... N-acetyl-aspartate was lower in the left MTC (27%) in MDD patients versus controls. More...
N-acetyl-aspartate (NAA)		right anterior cingulate cortex(right anterior cingulate(AC))	brain morphology and function	Olvera, 2010	patients and normal controls		MDD subjects showed significantly lower levels of NAA in the...... MDD subjects showed significantly lower levels of NAA in the right MPFC and right AC than controls. More...
N-acetyl-aspartate (NAA)		right medial prefrontal cortex (MPFC)(right medial prefrontal cortex (MPFC))	brain morphology and function	Olvera, 2010	patients and normal controls		MDD subjects showed significantly lower levels of NAA in the...... MDD subjects showed significantly lower levels of NAA in the right MPFC and right AC than controls. More...
N-acetylaspartate		Anhedonia(anhedonia)	symptoms	Walter, 2009	patients and normal controls		Glutamate and N-acetylaspartate concentrations correlate wit...... Glutamate and N-acetylaspartate concentrations correlate with emotional intensity ratings, an anhedonia surrogate, in those with MDD but not in healthy subjects More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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Name in Literature	Reference	Research Type	Statistical Result	Relation Description
N-acetyl-aspartate	Auer, 2000	patients and normal controls		There was no significant group effect for the neuronal marke...... There was no significant group effect for the neuronal marker NAA, creatine, choline or myo-inositol in either localization. More...