Study Report
Reference
| Citation | Chen, 2009 PubMed |
| Full Info | Chen, C.S., Chiang, I.C., Li, C.W., Lin, W.C., Lu, C.Y., Hsieh, T.J., Liu, G.C., Lin, H.F. and Kuo, Y.T. (2009) Proton magnetic resonance spectroscopy of late-life major depressive disorder. Psychiatry Res, 172, 210-214.
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Study
| Hypothesis or Background |
The primary goal of this study was to examine the biochemical abnormalities of late-life major depression by using 3-tesla (3-T) proton magnetic resonance spectroscopy ((1)H-MRS). The antidepressant effects on the biochemical abnormalities were investigated as well.
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| Sample Information | Study participants were 27 elderly patients with major depressive disorders (among which 9 were on antidepressant medication) and 19 comparison elderly subjects. |
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| Method Detail | (1)H-MRS spectra were acquired from voxels that were placed in the left frontal white matter, left periventricular white matter, and left basal ganglia. Ratios of N-acetylaspartate (NAA), choline (Cho) and myo-inositol to creatine were calculated. |
| Method Keywords | spectrophotometric analysis |
| Result | Patients with late-life major depressive disorder had a significantly lower NAA/creatine ratio in the left frontal white matter, and higher Cho/creatine and myo-inositol/creatine ratios in the left basal ganglia when compared with the control subjects. The myo-inositol correlated with global cognitive function among the patients. The biochemical abnormalities in late-life major depressive disorder were found on the left side of the frontal white matter and the basal ganglia. |
| Conclusions | Neuron degeneration in the frontal white matter and second messenger system dysfunction or glial dysfunction in the basal ganglia are suggested to be associated with late-life depression. |
Relationships reported by
Chen, 2009
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
N-acetylaspartate (N-acetylaspartate (NAA)) |
molecule |
|
Patients with late-life major depressive disorder had a significantly lower NAA/creatine ratio in the left frontal white matter when compared with the control subjects. |
Positive
|
|
MDD
|
syndrome |
Inositol (myo-inositol) |
molecule |
|
Patients with late-life major depressive disorder had a significantly higher myo-inositol/creatine ratios in the left basal ganglia when compared with the control subjects. |
Positive
|
|
MDD
|
syndrome |
Creatine (creatine) |
molecule |
|
Patients with late-life major depressive disorder had a significantly lower NAA/creatine ratio in the left frontal white matter, and higher Cho/creatine and myo-inositol/creatine ratios in the left basal ganglia when compared with the control subjects. |
Positive
|
|
MDD
|
syndrome |
Choline (choline (Cho)) |
molecule |
|
Patients with late-life major depressive disorder had a significantly higher Cho/creatine in the left basal ganglia when compared with the control subjects. |
Positive
|
|
MDD
|
syndrome |
White matter (white matter) |
brain morphology and function |
|
The biochemical abnormalities in late-life major depressive disorder were found on the left side of the frontal white matter. |
Positive
|
|
MDD
|
syndrome |
Basal ganglia (basal ganglia) |
brain morphology and function |
|
The biochemical abnormalities in late-life major depressive disorder were found on the basal ganglia. |
Positive
|
