Molecule Report

Name	Creatine
Description	An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as CREATININE in the urine.
MeSH ID	D003401
No. of Studies (Positive/Negative)	10(9/1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
creatine-phosphocreatine (Cr)	Kusumakar, 2001	patients and normal controls	t = 2.624, df 10, P-value = 0.025	Subjects with depression demonstrated lower left amygdala Ch...... Subjects with depression demonstrated lower left amygdala Cho-Cr ratios, compared with control subjects (paired t = 2.624, df 10, P = 0.025). More...
creatine	Kumar, 2002	patients and normal controls		myo-Inositol/creatine and choline/creatine ratios were signi...... myo-Inositol/creatine and choline/creatine ratios were significantly higher in the frontal white matter in the major depression group than in the comparison group. More...
creatine (Cr)	Vythilingam, 2003	patients and normal controls		Compared with control subjects, MDD patients had a significa...... Compared with control subjects, MDD patients had a significantly lower mean NAA/Cr amplitude in the caudate and a significantly higher mean Cho/Cr amplitude in the putamen, particularly on the right side. More...
creatine	Coupland, 2005	patients and normal controls	F(1,23)=6.9; P-value=0.016	Patients with MDD showed significantly lower myo-inositol/cr...... Patients with MDD showed significantly lower myo-inositol/creatine ratios (.94+/-.23) than control subjects (1.32+/-.37) [F(1,23)=6.9; p=.016]. More...
creatine	Gabbay, 2007	patients and normal controls		Relative to comparison subjects, adolescents with major depr...... Relative to comparison subjects, adolescents with major depressive disorder had significantly elevated concentrations of choline (2.11 mM versus 1.56 mM) and creatine (6.65 mM versus 5.26 mM) in the left caudate. More...
creatine	Chen, 2009	patients and normal controls		Patients with late-life major depressive disorder had a sign...... Patients with late-life major depressive disorder had a significantly lower NAA/creatine ratio in the left frontal white matter, and higher Cho/creatine and myo-inositol/creatine ratios in the left basal ganglia when compared with the control subjects. More...
creatine	Nery, 2009	patients and normal controls		Male MDD patients presented lower levels of PCr+Cr (phosphoc...... Male MDD patients presented lower levels of PCr+Cr (phosphocreatine plus creatine) than male healthy controls (HC), female MDD patients presented higher levels of PCr+Cr than female HC. More...
creatine	Horn, 2010	patients and normal controls		Creatine in the pgACC were lowest in severely depressed pati...... Creatine in the pgACC were lowest in severely depressed patients. More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
creatine (Cr)		Reaction time(processing speed)	cognition and behavior	Elderkin-Thompson, 2004	patients and normal controls		There was a significant difference in the overall pattern of...... There was a significant difference in the overall pattern of associations between the four metabolites (Ch, PCh, Cr, and mI) and verbal learning and processing speed in depressed patients compared to healthy controls. More...
creatine (Cr)		Learning(verbal learning)	cognition and behavior	Elderkin-Thompson, 2004	patients and normal controls		There was a significant difference in the overall pattern of...... There was a significant difference in the overall pattern of associations between the four metabolites (Ch, PCh, Cr, and mI) and verbal learning and processing speed in depressed patients compared to healthy controls. More...

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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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Name in Literature	Reference	Research Type	Statistical Result	Relation Description
creatine	Auer, 2000	patients and normal controls		There was no significant group effect for the neuronal marke...... There was no significant group effect for the neuronal marker NAA, creatine, choline or myo-inositol in either localization. More...