Study Report
Reference
| Citation | Kusumakar, 2001 PubMed |
| Full Info | Kusumakar, V., MacMaster, F.P., Gates, L., Sparkes, S.J. and Khan, S.C. (2001) Left medial temporal cytosolic choline in early onset depression. Can J Psychiatry, 46, 959-964.
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Study
| Hypothesis or Background |
Previous studies have linked the choline (Cho) resonance seen in proton magnetic resonance spectroscopy (1H-MRS) to major depressive disorder (MDD). We endeavoured to clarify the possible involvement of cytosolic choline in the amygdala (anterior medial temporal region) of juvenile subjects with MDD.
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| Sample Information | A total of 11 age- and sex-matched MDD and control pairs aged 14 to 18 years |
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| Method Detail | A total of 11 age- and sex-matched MDD and control pairs aged 14 to 18 years participated in long-echo proton magnetic resonance spectroscopic imaging (1H-MRSI) of the amygdala. Compounds available include N-acetyl-aspartate (NAA), creatine-phosphocreatine (Cr) and choline-containing compounds. |
| Method Keywords | spectrophotometric analysis |
| Result | Subjects with depression demonstrated lower left amygdala Cho-Cr ratios, compared with control subjects (paired t = 2.624, df 10, P = 0.025). Left amygdala NAA-Cr and right amygdala Cho-Cr and NAA-Cr did not differ significantly between subjects with depression and control subjects. In subjects with depression, simple regression revealed a negative trend between left amygdala Cho-Cr and Beck Depression Inventory (BDI) score (F = 3.509, P = 0.098). Right amygdala NAA-Cr and Cho-Cr did not differ significantly. |
| Conclusions | Cytosolic choline appears to be involved in the pathophysiology of early-onset MDD, likely secondary to corticosteroid-neuroendocrine-driven changes. |
Relationships reported by
Kusumakar, 2001
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
Choline (choline (Cho)) |
molecule |
t = 2.624, df 10, P-value = 0.025 |
Subjects with depression demonstrated lower left amygdala Cho-Cr ratios, compared with control subjects (paired t = 2.624, df 10, P = 0.025). |
Positive
|
|
MDD
|
syndrome |
Creatine (creatine-phosphocreatine (Cr)) |
molecule |
t = 2.624, df 10, P-value = 0.025 |
Subjects with depression demonstrated lower left amygdala Cho-Cr ratios, compared with control subjects (paired t = 2.624, df 10, P = 0.025). |
Positive
|
