Study Report
Reference
| Citation | Coupland, 2005 PubMed |
| Full Info | Coupland, N.J., Ogilvie, C.J., Hegadoren, K.M., Seres, P., Hanstock, C.C. and Allen, P.S. (2005) Decreased prefrontal Myo-inositol in major depressive disorder. Biol Psychiatry, 57, 1526-1534.
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Study
| Hypothesis or Background |
Postmortem studies have shown robust prefrontal cortex glial losses and more subtle neuronal changes in major depressive disorder (MDD). Earlier proton magnetic resonance spectroscopy (1H-MRS) studies of the glial marker myo-inositol in MDD were subject to potential confounds. The primary hypothesis of this study was that MDD patients would show reduced prefrontal/anterior cingulate cortex levels of myo-inositol.
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| Sample Information | Thirteen nonmedicated moderate-severe MDD patients and 13 matched control subjects were studied (six male, seven female per group). |
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| Method Detail | Proton magnetic resonance spectroscopy stimulated echo acquisition mode spectra (3.0 T; echo time=168 msec; mixing time=28 msec; repetition time=3000 msec) were obtained from prefrontal/anterior cingulate cortex. Metabolite data were adjusted for tissue composition. |
| Method Keywords | spectrophotometric analysis |
| Result | Patients with MDD showed significantly lower myo-inositol/creatine ratios (.94+/-.23) than control subjects (1.32+/-.37) [F(1,23)=6.9; p=.016]. |
| Conclusions | These data suggest a reduction of myo-inositol in prefrontal/anterior cingulate cortex in MDD, which could be a consequence of glial loss or altered glial metabolism. Additional in vivo studies of glial markers could add to the understanding of the pathophysiology of MDD. |
Relationships reported by
Coupland, 2005
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
Inositol (myo-inositol) |
molecule |
F(1,23)=6.9; P-value=0.016 |
Patients with MDD showed significantly lower myo-inositol/creatine ratios (.94+/-.23) than control subjects (1.32+/-.37) [F(1,23)=6.9; p=.016]. |
Positive
|
|
MDD
|
syndrome |
Creatine (creatine) |
molecule |
F(1,23)=6.9; P-value=0.016 |
Patients with MDD showed significantly lower myo-inositol/creatine ratios (.94+/-.23) than control subjects (1.32+/-.37) [F(1,23)=6.9; p=.016]. |
Positive
|
