Molecule Report

Name	Inositol
Description	An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction
MeSH ID	D007294
No. of Studies (Positive/Negative)	10(9/1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
myo-inositol	Kumar, 2002	patients and normal controls		myo-Inositol/creatine and choline/creatine ratios were signi...... myo-Inositol/creatine and choline/creatine ratios were significantly higher in the frontal white matter in the major depression group than in the comparison group. More...
myo-inositol	Caetano, 2005	patients and normal controls		Depressed subjects had significantly lower levels of glycero...... Depressed subjects had significantly lower levels of glycerophosphocholine plus phosphocholine (GPC + PC; or choline-containing compounds) and higher myo-inositol levels in the left DLPFC compared to healthy controls. I More...
myo-inositol	Coupland, 2005	patients and normal controls	F(1,23)=6.9; P-value=0.016	Patients with MDD showed significantly lower myo-inositol/cr...... Patients with MDD showed significantly lower myo-inositol/creatine ratios (.94+/-.23) than control subjects (1.32+/-.37) [F(1,23)=6.9; p=.016]. More...
myo-inositol	Chen, 2009	patients and normal controls		Patients with late-life major depressive disorder had a sign...... Patients with late-life major depressive disorder had a significantly higher myo-inositol/creatine ratios in the left basal ganglia when compared with the control subjects. More...
Myo-inositol (MI)	Milne, 2009	patients and normal controls		The group presenting for first treatment had only increases ...... The group presenting for first treatment had only increases in MI levels compared with matched controls. More...
myo-inositol	Taylor, 2009	patients and normal controls		myo-inositol concentrations were significantly higher in tho...... myo-inositol concentrations were significantly higher in those with a history of depression than in controls. More...
myo-inositol	Zheng, 2010	patients only	P-value<0.001	In depressive patients a significant reduction in myo-inosit...... In depressive patients a significant reduction in myo-inositol (m-Ino) was observed pre-rTMS (p<0.001).After successful treatment, m-Ino increased significantly in left PFC and the levels no longer differed from those of age-matched controls. More...
myo-inositol	Jarnum, 2011	patients and normal controls		significantly reduced myo-inositol levels in MDD patients co...... significantly reduced myo-inositol levels in MDD patients compared with healthy controls at baseline. More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
myo-inositol (ml)		Reaction time(processing speed)	cognition and behavior	Elderkin-Thompson, 2004	patients and normal controls		There was a significant difference in the overall pattern of...... There was a significant difference in the overall pattern of associations between the four metabolites (Ch, PCh, Cr, and mI) and verbal learning and processing speed in depressed patients compared to healthy controls. More...
myo-inositol (ml)		Learning(verbal learning)	cognition and behavior	Elderkin-Thompson, 2004	patients and normal controls		There was a significant difference in the overall pattern of...... There was a significant difference in the overall pattern of associations between the four metabolites (Ch, PCh, Cr, and mI) and verbal learning and processing speed in depressed patients compared to healthy controls. More...

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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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Name in Literature	Reference	Research Type	Statistical Result	Relation Description
myo-inositol	Auer, 2000	patients and normal controls		There was no significant group effect for the neuronal marke...... There was no significant group effect for the neuronal marker NAA, creatine, choline or myo-inositol in either localization. More...