Study Report
Reference
| Citation | Jarnum, 2011 PubMed |
| Full Info | Jarnum, H., Eskildsen, S.F., Steffensen, E.G., Lundbye-Christensen, S., Simonsen, C.W., Thomsen, I.S., Frund, E.T., Theberge, J. and Larsson, E.M. (2011) Longitudinal MRI study of cortical thickness, perfusion, and metabolite levels in major depressive disorder. Acta Psychiatr Scand, 124, 435-446.
|
Study
| Hypothesis or Background |
To determine whether patients with major depressive disorder (MDD) display morphologic, functional, and metabolic brain abnormalities in limbic-cortical regions at a baseline magnetic resonance (MR) scan and whether these changes are normalized in MDD patients in remission at a follow-up scan.
|
| Sample Information | We examined 23 MDD patients and 26 healthy controls. |
|---|
| Method Detail | A longitudinal 3.0-Tesla (T) magnetic resonance imaging (MRI) study was carried out with cortical thickness measurements with a surface-based approach, perfusion measurements with three-dimensional (3D) pseudo-continuous arterial spin labeling (pCASL), and spectroscopy (1H-MRS) measurements in the anterior cingulate cortex (ACC) with water as an internal reference adjusted for cerebrospinal fluid content. We examined 23 MDD patients and 26 healthy controls. MDD patients underwent a baseline MRI at inclusion and were invited to a follow-up scan when they were in remission or after a 6-month follow-up period. |
| Method Keywords | magnetic resonance imaging (MRI) |
| Result | Major findings were a significantly thinner posterior cingulate cortex in non-remitters than in remitters, a significant decrease in perfusion in the frontal lobes and the ACC in non-remitters compared with healthy controls at baseline and significantly reduced N-acetylaspartate, myo-inositol, and glutamate levels in MDD patients compared with healthy controls at baseline. |
| Conclusions | Using novel MRI techniques, we have found abnormalities in cerebral regions related to cortical-limbic pathways in MDD patients. |
Relationships reported by
Jarnum, 2011
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
Frontal Lobe (frontal lobe) |
brain morphology and function |
|
A significant decrease in perfusion in the frontal lobes in non-remitters compared with healthy controls at baseline |
Positive
|
|
MDD
|
syndrome |
Anterior cingulate cortex (anterior cingulate cortex (ACC)) |
brain morphology and function |
|
A significant decrease in perfusion in the ACC in non-remitters compared with healthy controls at baseline |
Positive
|
|
MDD
|
syndrome |
Posterior cingulate cortex (posterior cingulate cortex) |
brain morphology and function |
|
Major findings were a significantly thinner posterior cingulate cortex in non-remitters than in remitters |
Positive
|
|
MDD
|
syndrome |
Glutamates (glutamate) |
molecule |
|
significantly reduced glutamate levels in MDD patients compared with healthy controls at baseline. |
Positive
|
|
MDD
|
syndrome |
N-acetylaspartate (N-acetylaspartate) |
molecule |
|
significantly reduced N-acetylaspartate levels in MDD patients compared with healthy controls at baseline. |
Positive
|
|
MDD
|
syndrome |
Inositol (myo-inositol) |
molecule |
|
significantly reduced myo-inositol levels in MDD patients compared with healthy controls at baseline. |
Positive
|
