Molecule Report
Basic Information
| Name | Glutamates |
|---|---|
| Description | salts & esters of glutamic acid, an amino acid |
| MeSH ID | D005971 |
| No. of Studies (Positive/Negative) | 19(19/0)
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Positive relationship between Glutamates and MDD (count: 16)
| Name in Literature | Reference | Research Type | Statistical Result | Relation Description |
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| Glu (glutamate alone) | Auer, 2000 | patients and normal controls | decrease of Glu in patients with major depressive episodes decrease of Glu in patients with major depressive episodes | ||
| glutamate | Pfleiderer, 2003 | patients and normal controls | We observed significantly reduced Glx (glutamate/glutamine) ...... We observed significantly reduced Glx (glutamate/glutamine) levels in the patients' left cingulum compared to healthy controls. More... | ||
| glutamate | Michael, 2003 | patients and normal controls | In depressed patients reduced glutamate/glutamine (Glx) leve...... In depressed patients reduced glutamate/glutamine (Glx) levels were measured pre-ECT; Glx concentrations correlated negatively with severity of depression. More... | ||
| glutamate | Mirza, 2004 | patients and normal controls | Anterior cingulate glutamatergic (glutamate/glutamine Glx) c...... Anterior cingulate glutamatergic (glutamate/glutamine Glx) concentrations were significantly lower (19% decrease) in MDD patients versus controls (9.27 +/- 0.43 versus 11.47 +/- 0.26, respectively, p = 0.000). More... | ||
| glutamate | Sanacora, 2004 | patients and normal controls | P-value<0.01 | mean glutamate levels were significantly increased in depres...... mean glutamate levels were significantly increased in depressed subjects compared with healthy controls (P<.001). More... | |
| glutamate | Caetano, 2005 | patients and normal controls | In the depressed subjects, we found significant inverse corr...... In the depressed subjects, we found significant inverse correlations between glutamate levels and both duration of illness and number of episodes. More... | ||
| glutamate | Hasler, 2005 | patients and normal controls | Secondary analyses provided preliminary evidence for a negat...... Secondary analyses provided preliminary evidence for a negative relationship between the glutamate/glutamine (Glx)/GABA ratio and age of onset of major depression in the ventromedial prefrontal cortex. More... | ||
| glutamate | Rosenberg, 2005 | patients and normal controls | P-value=0.0002 | Reduced anterior cingulate glutamate was observed in MDD pat...... Reduced anterior cingulate glutamate was observed in MDD patients versus control subjects (8.79 +/- 1.68 vs. 11.46 +/- 1.55, respectively, p = .0002; 23% decrease). More... | |
| glutamate (Glu) | Bhagwagar, 2007 | patients and normal controls | Occipital levels of GABA and NAA were significantly lower in...... Occipital levels of GABA and NAA were significantly lower in recovered depressed and bipolar subjects than in healthy controls, whereas Glu +Gln concentrations were higher. More... | ||
| glutamate | Hasler, 2007 | patients and normal controls | Depressed patients had reduced Glx (glutamate/glutamine) lev...... Depressed patients had reduced Glx (glutamate/glutamine) levels in both ROIs(region of interest). More... | ||
| glutamate | Hashimoto, 2007 | patients only | Increased levels of glutamate were observed in the frontal c...... Increased levels of glutamate were observed in the frontal cortex from patients with bipolar disorder and major depression. More... | ||
| glutamate | Block, 2009 | patients and normal controls | In the cross-sectional comparison, we observed a significant...... In the cross-sectional comparison, we observed a significant reduction of the metabolic ratios Glx/Cr (Glx=glutamine, glutamate and gamma-aminobutyric acid) and glutamine (Gln)/Cr in the patient group. More... | ||
| glutamate | Walter, 2009 | patients and normal controls | Glutamate concentrations in pgACC correlate with negative BO...... Glutamate concentrations in pgACC correlate with negative BOLD responses induced by emotional stimulation in MDD. More... | ||
| glutamate | Horn, 2010 | patients and normal controls | the sum of Glutamate in the pgACC predicted the resting-sta...... the sum of Glutamate in the pgACC predicted the resting-state functional connectivity between the two regions exclusively in depressed patients. More... | ||
| Glutamate (Glu) | Portella, 2011 | patients and normal controls | P-value < 0.001 | Levels of Glu were significantly decreased in remitted-recur...... Levels of Glu were significantly decreased in remitted-recurrent and chronic patients compared with both first-episode and controls (up to 28% mean reduction; p < 0.001, Cohen's d = 2.88) and were negatively correlated with illness duration (r = -0.56; p < 0.001). More... | |
| glutamate | Jarnum, 2011 | patients and normal controls | significantly reduced glutamate levels in MDD patients compa...... significantly reduced glutamate levels in MDD patients compared with healthy controls at baseline. More... |
Positive relationships between Glutamates and other components at different levels (count: 4)
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Positive relationship network of Glutamates in MK4MDD
Network loading ...
Note:
1. The different color of the nodes denotes the level of the nodes.
| Genetic/Epigenetic Locus | Protein and Other Molecule | Cell and Molecular Pathway | Neural System | Cognition and Behavior | Symptoms and Signs | Environment | MDD |
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3. The network is generated using Cytoscape Web
Negative relationship between Glutamates and MDD (count: 0)
Negative relationships between Glutamates and other components at different levels (count: 0)