Study Report
Reference
| Citation | Pfleiderer, 2003 PubMed |
| Full Info | Pfleiderer, B., Michael, N., Erfurth, A., Ohrmann, P., Hohmann, U., Wolgast, M., Fiebich, M., Arolt, V. and Heindel, W. (2003) Effective electroconvulsive therapy reverses glutamate/glutamine deficit in the left anterior cingulum of unipolar depressed patients. Psychiatry Res, 122, 185-192.
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Study
| Hypothesis or Background |
Cortical glutamate/glutamine (Glx) metabolism seems to be affected by a major depressive disorder. Recently, a Glx deficit was detected by proton magnetic resonance spectroscopy (1H-MRS) in the bilateral anterior cingulum of depressives. The aim of this study was to assess the effect of successful electroconvulsive therapy (ECT) on Glx levels in the anterior cingulum.
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| Sample Information | 17 severely depressed unipolar patients and 17 age- and gender-matched controls |
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| Method Detail | The left anterior cingulum of 17 severely depressed unipolar patients was measured by 1H STEAM spectroscopy before and after ECT, and the results were compared with those for 17 age- and gender-matched controls. |
| Method Keywords | spectrophotometric analysis |
| Result | We observed significantly reduced Glx levels in the patients' left cingulum compared to healthy controls. In ECT responders, in contrast to non-responders, Glx levels normalized (P=0.04) and then did not differ statistically from controls. |
| Conclusions | Severe depression seems to be associated with a Glx deficit and increasing Glx may be an important mechanism of ECT action. |
Relationships reported by
Pfleiderer, 2003
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
Glutamates (glutamate) |
molecule |
|
We observed significantly reduced Glx (glutamate/glutamine) levels in the patients' left cingulum compared to healthy controls. |
Positive
|
|
MDD
|
syndrome |
Glutamine (glutamine) |
molecule |
|
We observed significantly reduced Glx (glutamate/glutamine) levels in the patients' left cingulum compared to healthy controls. |
Positive
|
|
MDD
|
syndrome |
left cingulum (left cingulum) |
brain morphology and function |
|
We observed significantly reduced Glx (glutamate/glutamine) levels in the patients' left cingulum compared to healthy controls. |
Positive
|
